Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Edwin P. Zwart"'
Autor:
Victoria C. de Leeuw, Conny T. M. van Oostrom, Edwin P. Zwart, Harm J. Heusinkveld, Ellen V. S. Hessel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3608 (2023)
Dopamine is present in a subgroup of neurons that are vital for normal brain functioning. Disruption of the dopaminergic system, e.g., by chemical compounds, contributes to the development of Parkinson’s disease and potentially some neurodevelopmen
Externí odkaz:
https://doaj.org/article/6041263aadbd461b92c89bc650db0476
Autor:
Anne Havermans, Edwin P. Zwart, Hans W. J. M. Cremers, Maarten D. M. van Schijndel, Romy S. Constant, Maja Mešković, Laura X. Worutowicz, Jeroen L. A. Pennings, Reinskje Talhout, Leo T. M. van der Ven, Harm J. Heusinkveld
Publikováno v:
Toxics, Vol 9, Iss 10, p 250 (2021)
Tobacco use is the leading cause of preventable death worldwide and is highly addictive. Nicotine is the main addictive compound in tobacco, but less is known about other components and additives that may contribute to tobacco addiction. The zebrafis
Externí odkaz:
https://doaj.org/article/74351150c4494a4e9ae6db16f5ed16fa
Autor:
Leo T.M. Van Der Ven, Paul Van Ommeren, Edwin P. Zwart, Eric R. Gremmer, Hennie M. Hodemaekers, Harm J. Heusinkveld, Jacob D. van Klaveren, Emiel Rorije
Publikováno v:
Environmental health perspectives. 130(4)
Humans are exposed to combinations of chemicals. In cumulative risk assessment (CRA), regulatory bodies such as the European Food Safety Authority consider dose addition as a default and sufficiently conservative approach. The principle of dose addit
Autor:
Sarah Moody, Volker M. Arlt, Michael R. Stratton, Veronica Duffy, David H. Phillips, Lucie Loutkotová, Edwin P. Zwart, Jill E. Kucab, Lisa Hölzl-Armstrong, Mirjam Luijten, Gonçalo Gamboa da Costa
Publikováno v:
Archives of Toxicology
Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its reactive metabolite glycidamide, which forms pre-mutagenic DNA adducts. Using the human TP53 knock
Autor:
Edwin P. Zwart, Ingrid Jense, Harm J. Heusinkveld, Jessica Legradi, Ellen V.S. Hessel, Alessandro Atzei, Bastiaan J. Venhuis, Leo T.M. van der Ven
Publikováno v:
International Journal of Environmental Research and Public Health
Volume 18
Issue 13
International Journal of Environmental Research and Public Health, Vol 18, Iss 6717, p 6717 (2021)
Atzei, A, Jense, I, Zwart, E P, Legradi, J, Venhuis, B J, van der Ven, L T M, Heusinkveld, H J & Hessel, E V S 2021, ' Developmental neurotoxicity of environmentally relevant pharmaceuticals and mixtures thereof in a zebrafish embryo behavioural test ', International Journal of Environmental Research and Public Health, vol. 18, no. 13, 6717 . https://doi.org/10.3390/ijerph18136717
International Journal of Environmental Research and Public Health, 18(13):6717. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 18
Issue 13
International Journal of Environmental Research and Public Health, Vol 18, Iss 6717, p 6717 (2021)
Atzei, A, Jense, I, Zwart, E P, Legradi, J, Venhuis, B J, van der Ven, L T M, Heusinkveld, H J & Hessel, E V S 2021, ' Developmental neurotoxicity of environmentally relevant pharmaceuticals and mixtures thereof in a zebrafish embryo behavioural test ', International Journal of Environmental Research and Public Health, vol. 18, no. 13, 6717 . https://doi.org/10.3390/ijerph18136717
International Journal of Environmental Research and Public Health, 18(13):6717. Multidisciplinary Digital Publishing Institute (MDPI)
Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for devel
Autor:
Fatima den Ouden, Willem G. Schoonen, Emiel Rorije, Joop de Knecht, Edwin P. Zwart, Hennie M. Hodemaekers, Leo T.M. van der Ven, Renate M. Groot, Harm J. Heusinkveld
The zebrafish embryo toxicity test (ZFET) is a simple medium-throughput test to inform about (sub)acute lethal effects in embryos. Enhanced analysis through morphological and teratological scoring, and through gene expression analysis, detects develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc6788abb3fe6d8eeabac5f930497a
http://hdl.handle.net/10029/624957
http://hdl.handle.net/10029/624957
Autor:
Mirjam Luijten, David H. Phillips, Edwin P. Zwart, Lisa Hölzl-Armstrong, Volker M. Arlt, Jill E. Kucab
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 62(4)
TP53 harbors somatic mutations in more than half of human tumors with some showing characteristic mutation spectra that have been linked to environmental exposures. In bladder cancer, a unique distribution of mutations amongst several codons of TP53
Autor:
Volker M. Arlt, Robert J. Turesky, Michael R. Stratton, David H. Phillips, Edwin P. Zwart, Sarah Moody, Mirjam Luijten, Lisa Hölzl-Armstrong, Jill E. Kucab, Medjda Bellamri
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 147
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a possible human carcinogen formed in cooked fish and meat. PhIP is bioactivated by cytochrome P450 enzymes to form 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), a genoto
Autor:
Emiel Rorije, Edwin P. Zwart, Evelyn D. Olthof, Hedwig M. Braakhuis, Wout Slob, Mirjam Luijten, Jan van Benthem, Gerrit Wolterink, Ruud Woutersen, Jan Willem van der Laan, Eric R. Gremmer
Publikováno v:
Critical Reviews in Toxicology. 48:500-511
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to
Autor:
Leo T.M. van der Ven, Anne Havermans, Hans W J M Cremers, Edwin P. Zwart, Laura X Worutowicz, Jeroen L. A. Pennings, Maja Mešković, Romy S Constant, Harm J. Heusinkveld, Maarten D M van Schijndel, Reinskje Talhout
Publikováno v:
Toxics
Toxics, Vol 9, Iss 250, p 250 (2021)
Toxics; Volume 9; Issue 10; Pages: 250
Toxics, Vol 9, Iss 250, p 250 (2021)
Toxics; Volume 9; Issue 10; Pages: 250
Tobacco use is the leading cause of preventable death worldwide and is highly addictive. Nicotine is the main addictive compound in tobacco, but less is known about other components and additives that may contribute to tobacco addiction. The zebrafis