Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Edwin M. Meyer"'
Publikováno v:
Molecular Therapy. 15(9):1623-1629
The accumulation and deposition of the 40-42-amino acid peptide amyloid beta (Abeta) is thought to be a critical event in the pathology of Alzheimer's disease (AD). Both passive and active immunizations against Abeta in amyloid-depositing transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cd92a3216a41de0dbc0b16fdbfc009
Autor:
Ke Ren, Edwin M. Meyer, Italo Mocchetti, Rachel L. Nosheny, Alexander G. Yakovlev, Farid Ahmed, Lino Tessarollo
Publikováno v:
European Journal of Neuroscience. 25:2275-2284
Glycoprotein 120 (gp120) from the T-tropic strain of the human immunodeficiency virus type 1 has been shown to cause neuronal apoptosis through activation of the chemokine receptor CXCR4. Therefore, reducing CXCR4 expression may prevent gp120-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53685bee443027f0cdfd4ace3c75394a
https://doi.org/10.1111/j.1460-9568.2007.05506.x
https://doi.org/10.1111/j.1460-9568.2007.05506.x
Autor:
J. Liu, Jeffrey A. Hughes, Ke Ren, M.A. King, L. Ai, Edwin M. Meyer, Roger L. Papke, Jeffrey S. Thinschmidt
Publikováno v:
Neuroscience. 145:314-322
Brain alpha7 nicotinic receptors have become therapeutic targets for Alzheimer's disease (AD) based on their memory-enhancing and neuroprotective actions. This study investigated the feasibility of increasing neuronal alpha7 receptor functions using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5546b3841692ce6add02861ba3fd5e87
https://doi.org/10.1016/j.neuroscience.2006.11.023
https://doi.org/10.1016/j.neuroscience.2006.11.023
Publikováno v:
Brain Research. 1061:107-113
Nerve growth factor (NGF) therapy has been proposed to treat cognitive impairments in aged patients including those with Alzheimer's disease. Various viral vectors, including adeno-associated virus serotype 2 (AAV2), have been investigated for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5736552bde958e3a2839be143352d7
https://doi.org/10.1016/j.brainres.2005.08.056
https://doi.org/10.1016/j.brainres.2005.08.056
Publikováno v:
Experimental Neurology. 195:342-352
The hippocampus receives substantial input from the medial septum/diagonal band of broca (MS/DB) via the fibria-fornix (FF). Projections from the MS/DB innervate hippocampal interneurons that express alpha7 nicotinic receptors and regulate excitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4a505230f4be2072f941d070da905b
https://doi.org/10.1016/j.expneurol.2005.05.006
https://doi.org/10.1016/j.expneurol.2005.05.006
Publikováno v:
Journal of Neurochemistry. 94:926-933
α7 Nicotinic receptors are calcium permeant and provide neuroprotection against many insults. We investigated the roles of intracellular calcium ions and downstream calcium channels in this protection. The α7 agonist GTS-21 prevented pheochromocyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86cdb94c664002168cc66f604363fce
https://doi.org/10.1111/j.1471-4159.2005.03223.x
https://doi.org/10.1111/j.1471-4159.2005.03223.x
Autor:
Ralph Dawson, Masahiro Oka, Aaron C. Hirko, Naohiro Terada, Anthony Smith, Joanna Peris, Edwin M. Meyer, Yuka Nakano
Publikováno v:
Neurochemistry International. 45:1067-1073
This study characterized the presynaptic dopaminergic properties of neuronally differentiated mouse embryonic stem (ES) cells. Approximately 30% of the ES cells expressed tyrosine hydroxylase (TH) immunoreactivity when co-cultured with PA6 cells. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b57d260cf568e99dfb92f636edfae80
https://doi.org/10.1016/j.neuint.2004.05.005
https://doi.org/10.1016/j.neuint.2004.05.005
Publikováno v:
Molecular Pharmacology. 66:169-177
Although the muscle-type and homomeric alpha7-type nicotinic acetylcholine receptors (nAChRs) share many structural features and bind alpha-bungarotoxin with high affinity, several important functional and pharmacological properties distinguish these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecfdd1974ccfdbc2555537fb6acf78b
https://doi.org/10.1124/mol.66.1.169
https://doi.org/10.1124/mol.66.1.169
Publikováno v:
Molecular Therapy. 9:262-269
Nerve growth factor (NGF) therapy has been proposed to treat patients with age-related cognitive deficits, including those with Alzheimer's disease. One promising approach to delivering this protein into brain involves viral vectors. However, little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e297c19adadcf5633ac7e971695cb1
https://doi.org/10.1016/j.ymthe.2003.11.010
https://doi.org/10.1016/j.ymthe.2003.11.010
Autor:
Edwin M. Meyer, Jeffrey A. Hughes, Michael A. King, Ronald Klein, Williams J. Millard, Craig Meyers, Ke Wu
Publikováno v:
Human Gene Therapy. 14:1463-1472
Although NGF gene therapy has been proposed to treat age- or disease-related brain cholinergic decline, little is known about the ectopic expression or function of this trophic factor after transduction in the brain especially over long intervals. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ade2873e5095fa572a6f5879940a72
https://doi.org/10.1089/104303403769211673
https://doi.org/10.1089/104303403769211673