Reversible thrombocytopenia during hibernation originates from storage and release of platelets in liver sinusoids

Autor: Ben N G Giepmans, Ulrike Weerman, Edwin L de Vrij, Maaike Goris, Anne P de Groot, Hjalmar R. Bouma, Jeroen Kuipers, Robert H. Henning

Publikováno v: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Journal of Comparative Physiology B, Biochemical, Systemic and Environmental Physiology, 191(3), 603-615. SPRINGER HEIDELBERG

Immobility is a risk factor for thrombosis due to low blood flow, which may result in activation of the coagulation system, recruitment of platelets and clot formation. Nevertheless, hibernating animals—who endure lengthy periods of immobility—do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f16279e158e84c0dc1be7ad9b50d5c2
http://europepmc.org/articles/PMC8043940

Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia.

Autor: Edwin L de Vrij, Pieter C Vogelaar, Maaike Goris, Martin C Houwertjes, Annika Herwig, George J Dugbartey, Ate S Boerema, Arjen M Strijkstra, Hjalmar R Bouma, Robert H Henning

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93218 (2014)

Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity results in inactivity and decreased body temperature. Arousal periods intersperse the torpor bo

Externí odkaz: https://doaj.org/article/cc1ecf24042f48cba800b5264bc6dab0

Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system

Autor: Jantje J Bruintjes, Vera A Reitsema, Thaís M. A. Beuren, Robert H. Henning, Edwin L de Vrij, Marit Wiersma, Hjalmar R. Bouma, Bianca J. J. M. Brundel

Publikováno v: Comparative biochemistry and physiology b-Biochemistry & molecular biology, 223, 23-28. ELSEVIER SCIENCE INC
Wiersma, M, Beuren, T M A, de Vrij, E L, Reitsema, V A, Bruintjes, J J, Bouma, H R, Brundel, B J J M & Henning, R H 2018, ' Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system ', Comparative Biochemistry and Physiology Part-B: Biochemistry and Molecular Biology, vol. 223, pp. 23-28 . https://doi.org/10.1016/j.cbpb.2018.06.001
Comparative Biochemistry and Physiology Part-B: Biochemistry and Molecular Biology, 223, 23-28. Elsevier Inc.

Hibernation consists of torpor, with marked suppression of metabolism and physiological functions, alternated with arousal periods featuring their full restoration. The heart is particularly challenged, exemplified by its rate reduction from 400 to 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d22c5fe01d2b06055d23962dbacf6ea
https://research.rug.nl/en/publications/fcc1bf06-dea4-4556-8489-a11b0b89717e

How hibernation and hypothermia help to improve anticoagulant control

Autor: Edwin L de Vrij, Robert H. Henning

Publikováno v: Temperature: Multidisciplinary Biomedical Journal
Temperature (Austin, Tex.), 2(1), 44-46

Winter is coming. Some animals successfully cope with the hostility of this season by hibernating. But how do hibernators survive the procoagulant state of months of immobility at very low body temperatures, with strongly decreased blood flow and inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0395333be2c9f59c8ada38010c3dcd6
https://doi.org/10.4161/23328940.2014.967595

Inclusion of the benefits of enhanced cross-protection against cervical cancer and prevention of genital warts in the cost-effectiveness analysis of human papillomavirus vaccination in the Netherlands

Autor: Jan Wilschut, Hans W. Nijman, Toos Daemen, Tjalke A Westra, Irina Stirbu-Wagner, Maarten J. Postma, Eric D. Tutuhatunewa, Sara Dorsman, Edwin L de Vrij

Publikováno v: BMC Infectious Diseases, 13(1):75. BMC
BMC Infectious Diseases
BMC Infectious Diseases, Vol 13, Iss 1, p 75 (2013)

Background Infection with HPV 16 and 18, the major causative agents of cervical cancer, can be prevented through vaccination with a bivalent or quadrivalent vaccine. Both vaccines provide cross-protection against HPV-types not included in the vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e1050b7c3d7f95517198eab3f4683a
https://research.rug.nl/en/publications/c8a3efd0-b4db-4e8c-8d52-37934ec6030b