Výsledky vyhledávání - "Edwin K. Kuffner"

Akademický článek

A Pilot Study Assessing Common Medication Organizers for Child-Resistant Features

Autor: Lilai Teum, PharmD, Fallon Gokhman, PharmD, Sophia Park, PharmD, Daniel S. Budnitz, MD, MPH, Joseph W. Aquilina, MD, Edwin K. Kuffner, MD

Publikováno v: AJPM Focus, Vol 3, Iss 4, Pp 100232- (2024)

Introduction: Prescription and most over-the-counter medicines are required to have child-resistant packaging and/or labeled with instructions “Keep out of reach of children.” Although medication organizers are not required to have such design fe

Externí odkaz: https://doaj.org/article/b1abd655b09546fa903e87fd7dd8f668

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Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses

Autor: Junguo Zhou, Sandra De Jonghe, Ellen E. Codd, Sandy Weiner, David Gallacher, Paul Stahle, Michael F. Kelley, Edwin K. Kuffner, Christopher M. Flores, Gary E. Eichenbaum

Publikováno v: Regulatory toxicology and pharmacology : RTP.

JNJ-10450232 (NTM-006) is a new molecular entity that is structurally related to acetaminophen. A comprehensive non-clinical safety program was conducted to support first-in-human and clinical efficacy studies based on preclinical data suggesting tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adde6c1620b375340ef6e96be6ff72e1
https://pubmed.ncbi.nlm.nih.gov/36608923

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Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans

Autor: Heng-Keang Lim, Jie Chen, Wing Lam, Yong Gong, Laurent Leclercq, Jose Silva, Rhys Salter, Joris Berwaerts, Cathy K. Gelotte, Amy M. Vakil, Gary E. Eichenbaum, Edwin K. Kuffner, Christopher M. Flores

Publikováno v: Regulatory Toxicology and Pharmacology. :105379

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c06d22f7772dfc48f646cd0eb5ecb744
https://doi.org/10.1016/j.yrtph.2023.105379

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First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen

Autor: Cathy K. Gelotte, Amy M. Vakil, Joris Berwaerts, Brenda A. Zimmerman, Gary E. Eichenbaum, Christopher M. Flores, Edwin K. Kuffner

Publikováno v: Regulatory toxicology and pharmacology : RTP. 134

JNJ-10450232 (NTM-006) is a new molecular entity that comprises structural similarities to acetaminophen and provides comparable analgesia in animals and humans without causing the hepatotoxicity associated with acetaminophen overdose in preclinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd2b3bcfd9add9f3d693dd2ac4823cb
https://pubmed.ncbi.nlm.nih.gov/35934140

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Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting With Suspected Acute Myocardial Infarction or Unstable Angina

Publikováno v: Annals of emergency medicine. 35(5)

This clinical policy focuses on critical issues in the evaluation and management of patients with acute myocardial infarction or unstable angina. A MEDLINE search for articles published between January 1993 and December 1998 was performed using combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4dfa2a1e2cb9429918de5118818849
https://pubmed.ncbi.nlm.nih.gov/28140280

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Clinical policy: Critical issues in the evaluation and management of adult patients presenting with suspected pulmonary embolism

Publikováno v: Annals of Emergency Medicine. 41:257-270

This clinical policy focuses on critical issues in the evaluation and management of patients with signs or symptoms of pulmonary embolism (PE). A MEDLINE search for clinical trials published from January 1995 through April 2001 was performed using th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69049dcc645e1d87f23c62c6d45754f
https://doi.org/10.1067/mem.2003.40

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Clinical policy: Critical issues for the initial evaluation and management of patients presenting with a chief complaint of nontraumatic acute abdominal pain

Publikováno v: Annals of Emergency Medicine. 36:406-415

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377238087b62d0a1d374be8ac2700a34
https://doi.org/10.1067/mem.2000.109446

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Management of Acetaminophen Toxicity in the Intensive Care Unit

Autor: Kennon Heard, Lcdr Gerald F O'malley, Edwin K. Kuffner

Publikováno v: Journal of Intensive Care Medicine. 14:157-165

Acetaminophen poisoning is the most common cause of medication overdose death in the United States. While most patients can be safely managed outside the ICU, serious toxicity can result in hepatic failure and death. N-acetylcysteine has been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9611adfd91438e79b2c0c13e29e9234
https://doi.org/10.1046/j.1525-1489.1999.144157.x

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Ingestion of Low-Concentration Hydrofluoric Acid: An Insidious and Potentially Fatal Poisoning

Autor: Greg Bogdan, Richard C Dart, Edwin K. Kuffner, Wei Fong Kao

Publikováno v: Annals of Emergency Medicine. 34:35-41

Study objective: The purpose of this study was to provide the first description of the effects of ingestion of low-concentration hydrofluoric acid in a population reported to a regional poison control center. Methods: A retrospective analysis of data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e90c88a313ecbccdfcdf1a0c3d4e3b
https://doi.org/10.1016/s0196-0644(99)70269-6

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