Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Edwin J. Squirewell"'
1
Akademický článek
FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.
Autor: Joel B Heim, Cera A McDonald, Saranya P Wyles, Sindhuja Sominidi-Damodaran, Edwin J Squirewell, Ming Li, Catherine Motsonelidze, Ralph T Böttcher, Jan van Deursen, Alexander Meves
Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200558 (2018)
Focal adhesion kinase (FAK) is an intensely studied non-receptor tyrosine kinase with roles in cancer and other common human diseases. Despite the large interest in FAK, the in vivo contribution of FAK auto-phosphorylation site tyrosine (Y) 397 to FA
Externí odkaz: https://doaj.org/article/1109ccb00a0143719d68081d1a670d0e
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2
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1
Autor: Margaret O. James, Edwin J. Squirewell, Ricky Mareus, Peter W. Stacpoole, Lloyd P. Horne
Publikováno v: Drug Metab Dispos
Dichloroacetate (DCA) is an investigational drug that is used in the treatment of various congenital and acquired disorders of energy metabolism. Although DCA is generally well tolerated, some patients experience peripheral neuropathy, a side effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5687d0194a934fe504b0ff694ab972c
https://europepmc.org/articles/PMC7589945/
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3
Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats
Autor: Margaret O. James, Peter W. Stacpoole, Lloyd P. Horne, Marci Smeltz, Edwin J. Squirewell, Laura Rowland-Faux
Publikováno v: Drug Metab Dispos
Glutathione transferase zeta 1 (GSTZ1), expressed in liver and several extrahepatic tissues, catalyzes dechlorination of dichloroacetate (DCA) to glyoxylate. DCA inactivates GSTZ1, leading to autoinhibition of its metabolism. DCA is an investigationa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9b4ea9400bd65dcc9db0902cfaf510
https://europepmc.org/articles/PMC7589944/
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8
FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis
Autor: Cera A. McDonald, Edwin J. Squirewell, Joel B. Heim, Ming Li, Catherine Motsonelidze, Saranya P. Wyles, Jan M. van Deursen, Sindhuja Sominidi-Damodaran, Alexander Meves, Ralph T. Böttcher
Publikováno v: PLoS One
PLoS ONE, Vol 13, Iss 7, p e0200558 (2018)
PLoS ONE
Focal adhesion kinase (FAK) is an intensely studied non-receptor tyrosine kinase with roles in cancer and other common human diseases. Despite the large interest in FAK, the in vivo contribution of FAK auto-phosphorylation site tyrosine (Y) 397 to FA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117eac5d426690e190e4ba4430aac237
https://hdl.handle.net/21.11116/0000-0002-032B-B21.11116/0000-0002-032D-9
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10
Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
Autor: Larry W. Robertson, Victoria S. Parker, Hans-Joachim Lehmler, Edwin J. Squirewell, Michael W. Duffel
Publikováno v: Environmental toxicology and pharmacology. 58
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that are associated with varied adverse health effects. Lower chlorinated PCBs are prevalent in indoor and outdoor air and can be metabolized to their hydroxylated derivatives
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232b424dcd995313d66113b69a487c63
https://pubmed.ncbi.nlm.nih.gov/29408762
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