Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Edwin J. A. Veldhuizen"'
Autor:
Lianci Peng, Hongliang Tian, Yi Lu, Kaixiang Jia, Jinrong Ran, Qi Tao, Gang Li, Chao Wan, Chao Ye, Edwin J. A. Veldhuizen, Hongwei Chen, Rendong Fang
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-12 (2022)
Abstract Chicken cathelicidin-2 (CATH-2) as a host defense peptide has been identified to have potent antimicrobial and immunomodulatory activities. Here, we reported the mechanism by which CATH-2 modulates NLRP3 inflammasome activation. Our results
Externí odkaz:
https://doaj.org/article/034e4cafd6b7405cb4ffcbe63d65734f
Autor:
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1485 (2023)
The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually provides a protective layer
Externí odkaz:
https://doaj.org/article/4987097ab3a24735b6ab4d4bbe807274
Autor:
Qingkang Lyu, Edwin J. A. Veldhuizen, Irene S. Ludwig, Victor P. M. G. Rutten, Willem van Eden, Alice J. A. M. Sijts, Femke Broere
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/f15bdc6526144542a973a0251179bd78
Autor:
Albert van Dijk, Jennifer Anten, Anne Bakker, Noah Evers, Anna T. Hoekstra, Jung-Chin Chang, Maaike R. Scheenstra, Edwin J. A. Veldhuizen, Mihai G. Netea, Celia R. Berkers, Henk P. Haagsman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection
Externí odkaz:
https://doaj.org/article/d37d6ebc82eb4e7eac6d602f7bf731cf
Autor:
Lianci Peng, Maaike R. Scheenstra, Roel M. van Harten, Henk P. Haagsman, Edwin J. A. Veldhuizen
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-12 (2020)
Abstract Cathelicidins (CATHs) play an important role in the innate immune response against microbial infections. Among the four chicken cathelicidins, CATH-B1 is studied the least. In this study, the effect of CATH-B1 on the macrophage response towa
Externí odkaz:
https://doaj.org/article/6c0c19975e484945874af7b9015289ff
Autor:
Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bi
Externí odkaz:
https://doaj.org/article/8a53feac384048deba131cc874db54f3
Autor:
Melanie D. Balhuizen, Albert van Dijk, Jeroen W. A. Jansen, Chris H. A. van de Lest, Edwin J. A. Veldhuizen, Henk P. Haagsman
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high poten
Externí odkaz:
https://doaj.org/article/d3cc60f1c485413a823c3e5c82f8825d
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Gram-negative bacteria release vesicular structures from their outer membrane, so called outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal, communication, and antigen or toxin delivery. These vesicles are the pro
Externí odkaz:
https://doaj.org/article/c25e8f183c79436a92f9133721c68924
Autor:
Maaike R. Scheenstra, Roel M. van Harten, Edwin J. A. Veldhuizen, Henk P. Haagsman, Maarten Coorens
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cathelicidins are short cationic peptides that are part of the innate immune system. At first, these peptides were studied mostly for their direct antimicrobial killing capacity, but nowadays they are more and more appreciated for their immunomodulat
Externí odkaz:
https://doaj.org/article/0f32eed78e5645e0889a37cbafdb3227
Autor:
Lianci Peng, Wenjuan Du, Melanie D. Balhuizen, Henk P. Haagsman, Cornelis A. M. de Haan, Edwin J. A. Veldhuizen
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Cathelicidins (CATHs) are host defense peptides (HDPs) that play an important role in the innate immune response against infections. Although multiple functions of cathelicidins have been described, including direct antimicrobial activity and several
Externí odkaz:
https://doaj.org/article/3644800c49bc4797b380a68063949500