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pro vyhledávání: '"Edwin J C van der Schans"'
Publikováno v:
Human Molecular Genetics. 32:1-14
One of the most significant risk variants for Parkinson’s disease (PD), rs356182, is located at the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA-proximal variants, including rs356182, are thought to function in PD
Autor:
Edwin J C van der Schans, Steven E. Pierce, Jordan Prahl, Trevor A. Tyson, Alix Booms, Gerhard A. Coetzee
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-5 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
Genetic risk for complex diseases very rarely reflects only Mendelian-inherited phenotypes where single-gene mutations can be followed in families by linkage analysis. More commonly, a large set of low-penetrance, small effect-size variants combine t