Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Edwin J, Weeber"'
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Ketogenic and low-glycemic-index diets are effective in treating drug-resistant seizures in children with Angelman syndrome. Cognition, mobility, sleep, and gastrointestinal health are intrinsically linked to seizure activity and
Externí odkaz:
https://doaj.org/article/3d9cbcd1332a4d7b9d054ba35e14201f
Autor:
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine m
Externí odkaz:
https://doaj.org/article/f6fdfce93d6549e184299e4d7d512e9b
Publikováno v:
European Journal of Neuroscience. 57:1657-1670
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c57cd2a7621669b9b0eb199b83083b4f
https://doi.org/10.1111/ejn.15971
https://doi.org/10.1111/ejn.15971
Autor:
Hyun-ju Lee, Jin-Hee Park, Justin H. Trotter, James N. Maher, Kathleen E. Keenoy, You Mi Jang, Youngeun Lee, Jae-Ick Kim, Edwin J. Weeber, Hyang-Sook Hoe
Publikováno v:
Experimental Neurobiology. 32:42-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4da380d972cf066ea4a944c2945d739
https://doi.org/10.5607/en22044
https://doi.org/10.5607/en22044
Autor:
Heather A. Born, An T. Dao, Amber T. Levine, Wai Ling Lee, Natasha M. Mehta, Shubhangi Mehra, Edwin J. Weeber, Anne E. Anderson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly caused by deletion or mutation of the maternal allele of the UBE3A gene, with behavioral phenotypes and seizures as key features. Currently no treatment is availa
Externí odkaz:
https://doaj.org/article/f0286cef58f8494082fc0f0267c3148a
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 38-46 (2016)
Angelman syndrome (AS) is a rare genetic and neurological disorder presenting with seizures, developmental delay, ataxia, and lack of speech. Previous studies have indicated that oxidative stress-dependent metabolic dysfunction may underlie the pheno
Externí odkaz:
https://doaj.org/article/0c47e62a9c154abf8c06e0b380b4b76c
Autor:
Kevin Nash, Matthew Willman, Nicole K Morrill, Edwin J. Weeber, Hayden E. Greene, Austin W. Nenninger, Jonathan Willman, Andie Dodge, Kristina Lamens
Publikováno v:
Autism Research. 14:645-655
Disruptions to the maternally inherited allele UBE3A, encoding for an E3 ubiquitin ligase, leads to the manifestation of Angelman Syndrome (AS). While this disorder is rare, the symptoms are severe and lifelong including but not limited to: intractab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b72aabdf1316bcc1bd50a49da53b926
https://doi.org/10.1002/aur.2475
https://doi.org/10.1002/aur.2475
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Reelin is a neurodevelopmental protein important in adult synaptic plasticity and learning and memory. Recent evidence points to the importance for Reelin proteolysis in normal signaling and in cognitive function. Support for the dysfunction of Reeli
Externí odkaz:
https://doaj.org/article/7d2f646122484d3684952c78d419ca3c
Autor:
Edwin J. Weeber, Joseph C. Grieco, Sarah E. Harris, Heather A. Born, Angelique Regnier-Golanov, Luis A. Martinez, Anne E. Anderson
Publikováno v:
Clinical EEG and Neuroscience. 54:203-212
The goal of these studies was to use quantitative (q)EEG techniques on data from children with Angelman syndrome (AS) using spectral power analysis, and to evaluate this as a potential biomarker and quantitative method to evaluate therapeutics. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cdcc983319a64ab997e78aafab2450
https://doi.org/10.1177/1550059420973095
https://doi.org/10.1177/1550059420973095