Výsledky vyhledávání - "Edwin Haghnazari"

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors

Autor: Amit Verma, Li Zhou, Tony A. Navas, Simrit Parmar, Perry Pahanish, Linda S. Higgins, Jing Ying Ma, Yin Xu, Myka Estes, Lubomir Sokol, Aaron N. Nguyen, A. List, Leonidas C. Platanias, Mani Mohindru, Edwin Haghnazari, Irene Kerr, Robert H. Collins

Publikováno v: Blood. 108:4170-4177

The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic diseases characterized by refractory cytopenias as a result of ineffective hematopoiesis. Development of effective treatments has been impeded by limited insights into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089cf63c197a2ad721ebe99a9f52e97
https://doi.org/10.1182/blood-2006-05-023093

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The DNA damage checkpoint pathways exert multiple controls on the efficiency and outcome of the repair of a double-stranded DNA gap

Autor: Edwin Haghnazari, Wolf Dietrich Heyer

Publikováno v: Nucleic Acids Research. 32:4257-4268

A DNA gap repair assay was used to determine the effect of mutations in the DNA damage checkpoint system on the efficiency and outcome (crossover/non-crossover) of recombinational DNA repair. In Saccharomyces cerevisiae gap repair is largely achieved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf67aa526372913cd6da56470f479591
https://doi.org/10.1093/nar/gkh717

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The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide

Autor: Wolf Dietrich Heyer, Edwin Haghnazari

Publikováno v: DNA Repair. 3:769-776

The DNA damage checkpoint pathway and the MAP kinase pathway respond to various forms of environmental as well as endogenous stresses through signal transduction mechanisms involving protein kinases. Both pathways are intertwined in mammalian cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6e9b976ea4cd7b6e9a40175891d413
https://doi.org/10.1016/j.dnarep.2004.03.043

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Phosphorylation of Rad55 on Serines 2, 8, and 14 Is Required for Efficient Homologous Recombination in the Recovery of Stalled Replication Forks▿†

Autor: John R. Yates, Scott Anderson, Kristina Herzberg, Wolf Dietrich Heyer, Vladimir I. Bashkirov, W. Hayes McDonald, Elena V. Bashkirova, Edwin Haghnazari, Michael Rolfsmeier

DNA damage checkpoints coordinate the cellular response to genotoxic stress and arrest the cell cycle in response to DNA damage and replication fork stalling. Homologous recombination is a ubiquitous pathway for the repair of DNA double-stranded brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3f7b70f8401eebba9877b1cabbca92
https://europepmc.org/articles/PMC1636779/

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DNA Damage‐Induced Phosphorylation of Rad55 Protein as a Sentinel for DNA Damage Checkpoint Activation in S. cerevisiae

Autor: Wolf Dietrich Heyer, Vladimir I. Bashkirov, Edwin Haghnazari, Alexey S. Vlasenko, Kristina Herzberg

Rad55 protein is one of two Rad51 paralogs in the budding yeast Saccharomyces cerevisiae and forms a stable heterodimer with Rad57, the other Rad51 paralog. The Rad55-Rad57 heterodimer functions in homologous recombination during the assembly of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab015bae263e571e292a337f0a75e6f6
https://doi.org/10.1016/s0076-6879(05)09010-5

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SCIO-469, a Potent and Selective Inhibitor of p38a MAPK, Normalizes the Bone Marrow Microenvironment and Inhibits Multiple Myeloma Cell Proliferation in In Vitro and In Vivo Models

Autor: Linda S. Higgins, Aaron N. Nguyen, Margaret Henson, Satya Medicherla, Edwin Haghnazari, Elizabeth G. Stebbins, Jing Y. Ma, Andy Protter, Tony A. Navas, Mamatha M. Reddy, Ann M. Kapoun, Gilbert O'Young

Publikováno v: Blood. 104:1501-1501

Despite recent advances in the treatment of multiple myeloma (MM), this disease remains incurable. Accumulating evidence suggest that the bone marrow (BM) microenvironment of MM plays a critical role in tumor growth, survival, and drug resistance. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a82d8b4be18de2942b2e9c79cec4543
https://doi.org/10.1182/blood.v104.11.1501.1501

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Inhibition of p38 MAPK by SCIO-469 Suppresses TNF Generation and Promotes CD34+ Cell Survival in an In Vitro MDS Cell Culture Model

Autor: Aaron N. Nguyen, Tony A. Navas, Edwin Haghnazari, Elizabeth G. Stebbins, Alan F. List, Ruth Heaton, Linda S. Higgins, Jing Y. Ma

Publikováno v: Blood. 104:3424-3424

Progress in the development of more effective therapeutics for myelodysplastic syndrome (MDS) has been limited by the lack of targets critical to the pathobiology of the disease. Ineffective hematopoiesis in MDS is characterized by accelerated prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f1252ff0756b6d621d22e43b33e7826
https://doi.org/10.1182/blood.v104.11.3424.3424

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