Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Edwin H Cook"'
Autor:
Sunday M Francis, Soo-Jeong Kim, Emily Kistner-Griffin, Stephen Guter, Edwin H Cook, Suma Jacob
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Background: There are limited treatments available for autism spectrum disorder (ASD). Studies have reported significant associations between the receptor genes of oxytocin (OT) and vasopressin (AVP) and ASD diagnosis, as well as, ASD-related phenoty
Externí odkaz:
https://doaj.org/article/0e9231efd6fa4f34a7028bf147db88c1
Autor:
Joel Frohlich, Damla Senturk, Vidya Saravanapandian, Peyman Golshani, Lawrence T Reiter, Raman Sankar, Ronald L Thibert, Charlotte DiStefano, Scott Huberty, Edwin H Cook, Shafali S Jeste
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167179 (2016)
Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked w
Externí odkaz:
https://doaj.org/article/5ad9cd334e2f481bbbb1ec5e58393b99
Autor:
Stephen W Porges, Olga V Bazhenova, Elgiz eBal, Nancy eCarlson, Yevgeniya eSorokin, Keri J Heilman, Edwin H Cook, Gregory F Lewis
Publikováno v:
Frontiers in Pediatrics, Vol 2 (2014)
Auditory hypersensitivities are a common feature of autism spectrum disorder (ASD). In the present study the effectiveness of a novel intervention, the Listening Project Protocol (LPP) was evaluated in two trials conducted with children diagnosed wit
Externí odkaz:
https://doaj.org/article/e4fb8af3de694dcfaa3483ec9c52b950
Autor:
Andrey Rzhetsky, Steven C Bagley, Kanix Wang, Christopher S Lyttle, Edwin H Cook, Russ B Altman, Robert D Gibbons
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003518 (2014)
Many factors affect the risks for neurodevelopmental maladies such as autism spectrum disorders (ASD) and intellectual disability (ID). To compare environmental, phenotypic, socioeconomic and state-policy factors in a unified geospatial framework, we
Externí odkaz:
https://doaj.org/article/ee079b49409043d8aa8e98c030fd3739
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86469 (2014)
Because of the role played by miRNAs in post-transcriptional regulation of an array of genes, their impact in neuropsychiatric disease pathophysiology has increasingly been evident. In the present study, we assessed microRNA expression in prefrontal
Externí odkaz:
https://doaj.org/article/bba91b65f9924dfc9a20fe357f876ee9
Autor:
Lea K Davis, Dongmei Yu, Clare L Keenan, Eric R Gamazon, Anuar I Konkashbaev, Eske M Derks, Benjamin M Neale, Jian Yang, S Hong Lee, Patrick Evans, Cathy L Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrio, Oscar J Bienvenu, Michael H Bloch, Rianne M Blom, Ruth D Bruun, Cathy L Budman, Beatriz Camarena, Desmond Campbell, Carolina Cappi, Julio C Cardona Silgado, Danielle C Cath, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, David V Conti, Edwin H Cook, Vladimir Coric, Bernadette A Cullen, Dieter Deforce, Richard Delorme, Yves Dion, Christopher K Edlund, Karin Egberts, Peter Falkai, Thomas V Fernandez, Patience J Gallagher, Helena Garrido, Daniel Geller, Simon L Girard, Hans J Grabe, Marco A Grados, Benjamin D Greenberg, Varda Gross-Tsur, Stephen Haddad, Gary A Heiman, Sian M J Hemmings, Ana G Hounie, Cornelia Illmann, Joseph Jankovic, Michael A Jenike, James L Kennedy, Robert A King, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L Lowe, Fabio Macciardi, James T McCracken, Lauren M McGrath, Sandra C Mesa Restrepo, Rainald Moessner, Jubel Morgan, Heike Muller, Dennis L Murphy, Allan L Naarden, William Cornejo Ochoa, Roel A Ophoff, Lisa Osiecki, Andrew J Pakstis, Michele T Pato, Carlos N Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias J Renner, Victor I Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, Maria C Rosàrio, David Rosenberg, Guy A Rouleau, Stephan Ruhrmann, Andres Ruiz-Linares, Aline S Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey S Singer, Jan H Smit, Dan J Stein, E Strengman, Jay A Tischfield, Ana V Valencia Duarte, Homero Vallada, Filip Van Nieuwerburgh, Jeremy Veenstra-Vanderweele, Susanne Walitza, Ying Wang, Jens R Wendland, Herman G M Westenberg, Yin Yao Shugart, Euripedes C Miguel, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L Hanna, Peter Heutink, Damiaan Denys, Paul D Arnold, Ben A Oostra, Gerald Nestadt, Nelson B Freimer, David L Pauls, Naomi R Wray, S Evelyn Stewart, Carol A Mathews, James A Knowles, Nancy J Cox, Jeremiah M Scharf
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003864 (2013)
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quanti
Externí odkaz:
https://doaj.org/article/dcefb124869a49fdb60299acf97e56f6
Autor:
Li Liu, Aniko Sabo, Benjamin M Neale, Uma Nagaswamy, Christine Stevens, Elaine Lim, Corneliu A Bodea, Donna Muzny, Jeffrey G Reid, Eric Banks, Hillary Coon, Mark Depristo, Huyen Dinh, Tim Fennel, Jason Flannick, Stacey Gabriel, Kiran Garimella, Shannon Gross, Alicia Hawes, Lora Lewis, Vladimir Makarov, Jared Maguire, Irene Newsham, Ryan Poplin, Stephan Ripke, Khalid Shakir, Kaitlin E Samocha, Yuanqing Wu, Eric Boerwinkle, Joseph D Buxbaum, Edwin H Cook, Bernie Devlin, Gerard D Schellenberg, James S Sutcliffe, Mark J Daly, Richard A Gibbs, Kathryn Roeder
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003443 (2013)
We report on results from whole-exome sequencing (WES) of 1,039 subjects diagnosed with autism spectrum disorders (ASD) and 870 controls selected from the NIMH repository to be of similar ancestry to cases. The WES data came from two centers using di
Externí odkaz:
https://doaj.org/article/9939beeb8dd24c64a4ec4cb26f0d76e2
Autor:
Jerzy Wegiel, Janusz Frackowiak, Bozena Mazur-Kolecka, N Carolyn Schanen, Edwin H Cook, Marian Sigman, W Ted Brown, Izabela Kuchna, Jarek Wegiel, Krzysztof Nowicki, Humi Imaki, Shuang Yong Ma, Abha Chauhan, Ved Chauhan, David L Miller, Pankaj D Mehta, Michael Flory, Ira L Cohen, Eric London, Barry Reisberg, Mony J de Leon, Thomas Wisniewski
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35414 (2012)
BackgroundIt has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type-specific amount.Methodology/principal finding
Externí odkaz:
https://doaj.org/article/b0b05bdd307f40cfa10a399a7b5dca21
Autor:
Maja Bucan, Brett S Abrahams, Kai Wang, Joseph T Glessner, Edward I Herman, Lisa I Sonnenblick, Ana I Alvarez Retuerto, Marcin Imielinski, Dexter Hadley, Jonathan P Bradfield, Cecilia Kim, Nicole B Gidaya, Ingrid Lindquist, Ted Hutman, Marian Sigman, Vlad Kustanovich, Clara M Lajonchere, Andrew Singleton, Junhyong Kim, Thomas H Wassink, William M McMahon, Thomas Owley, John A Sweeney, Hilary Coon, John I Nurnberger, Mingyao Li, Rita M Cantor, Nancy J Minshew, James S Sutcliffe, Edwin H Cook, Geraldine Dawson, Joseph D Buxbaum, Struan F A Grant, Gerard D Schellenberg, Daniel H Geschwind, Hakon Hakonarson
Publikováno v:
PLoS Genetics, Vol 5, Iss 6, p e1000536 (2009)
The genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases, but has lacked the resolution necessary to move bey
Externí odkaz:
https://doaj.org/article/ef6efa22e8c1433a9509243981654366
Autor:
Ravinesh A Kumar, Christian R Marshall, Judith A Badner, Timothy D Babatz, Zohar Mukamel, Kimberly A Aldinger, Jyotsna Sudi, Camille W Brune, Gerald Goh, Samer Karamohamed, James S Sutcliffe, Edwin H Cook, Daniel H Geschwind, William B Dobyns, Stephen W Scherer, Susan L Christian
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4582 (2009)
Autism is a complex childhood neurodevelopmental disorder with a strong genetic basis. Microdeletion or duplication of a approximately 500-700-kb genomic rearrangement on 16p11.2 that contains 24 genes represents the second most frequent chromosomal
Externí odkaz:
https://doaj.org/article/8c5aebdca10a446baf691826ea0db006