Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Edwin G. Moore"'
Autor:
Yang Song, Giuseppe Léonardo Licari, Jeffrey S. Moore, Qian Chen, Edwin G. Moore, Emad Tajkhorshid, Chad M. Rienstra, John W. Smith, Abigail J. Halmes, Xing Jiang
Publikováno v:
ACS Macro Letters. 8:1365-1371
Protein aggregation is implicated in multiple deposition diseases including Alzheimer’s Disease, which features the formation of toxic aggregates of amyloid beta (Aβ) peptides. Many inhibitors have been developed to impede or reverse Aβ aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b7e1ffdedd34ac06315399bb86f457
https://doi.org/10.1021/acsmacrolett.9b00559
https://doi.org/10.1021/acsmacrolett.9b00559
Autor:
Chad M. Rienstra, Hyosung An, Xing Jiang, Alexander M. Barclay, John W. Smith, Emad Tajkhorshid, Edwin G. Moore, Jeffrey S. Moore, Giuseppe Léonardo Licari, Qian Chen
Publikováno v:
ACS applied nano materials. 3(2)
The assembly of proteins into amyloid fibrils has become linked not only with the progression of myriad human diseases, but also important biological functions. Understanding and controlling the formation, structure, and stability of amyloid fibrils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89be799ec5c6b1b5168b8ac41580bb63
https://pubmed.ncbi.nlm.nih.gov/32149271
https://pubmed.ncbi.nlm.nih.gov/32149271
Publikováno v:
Journal of the American Chemical Society. 139:4298-4301
Amyloid aggregation and deposition are associated with many intractable human diseases. Although the inhibition of amyloid protein aggregation has been well-studied, the disaggregation and dissolution of existing amyloid fibrils is less known. Taking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dfcd2bbfe15092da6b0cc0f5512b47
https://doi.org/10.1021/jacs.7b00289
https://doi.org/10.1021/jacs.7b00289
Autor:
Edwin G. Moore, Thomas Lo-Tseng, Alma L. Burlingame, Giulia Friso, Mehul Patel, JJ L. Miranda, Zhonghua Yu
Publikováno v:
Protein Science. 6:2568-2577
Diaspirin crosslinked hemoglobin (DCLHb) was analyzed by mass spectrometric-based techniques to identify the protein modifications effected by the crosslinking reaction with bis(3,5-dibromosalicyl) fumarate. DCLHb consists of two principal components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39966f203f0d437cd97ef2850466adde
https://doi.org/10.1002/pro.5560061209
https://doi.org/10.1002/pro.5560061209
Publikováno v:
Journal of the American Chemical Society. 136(14)
Manipulating the size and shape of noncovalent multivalent assemblies is an ongoing challenge in the field of supramolecular polymers. Following a mechanistic approach, we reasoned that nucleation-elongation kinetics presents unique opportunities for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f565c5a3221b5bf2395fbe9b4d63953
https://pubmed.ncbi.nlm.nih.gov/24661268
https://pubmed.ncbi.nlm.nih.gov/24661268
Autor:
Mehul J. Patel, Edwin J. Webb, Tina E. Shelbourn, Cynthia Mattia-Goldberg, Andrew J.T. George, Feng Zhang, Edwin G. Moore, Deanna J. Nelson
Publikováno v:
Blood. 91:710-716
Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::420069661226f4263dfb7aefe4bd6568
https://doi.org/10.1182/blood.v91.2.710.710_710_716
https://doi.org/10.1182/blood.v91.2.710.710_710_716
Autor:
Deanna J. Nelson, Tina E. Shelbourn, Cynthia Mattia-Goldberg, Edwin J. Webb, Edwin G. Moore, Feng Zhang, Mehul Patel, Andrew J.T. George
Publikováno v:
Blood. 91:710-716
Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f2a683bab42359e7483fb6c9f7dbab
https://doi.org/10.1182/blood.v91.2.710
https://doi.org/10.1182/blood.v91.2.710
Autor:
G. A. Tennent, J. R. Gallimore, Philip N. Hawkins, Edwin G. Moore, M H van Rijswijk, Julie Wilkins, Mark B. Pepys, Pieter Limburg
Publikováno v:
Clinical Chemistry. 40:1284-1290
Serum amyloid A (SAA), a sensitive acute-phase protein, is the precursor of AA fibrils in reactive amyloidosis. However, SAA is poorly immunogenic, and development and standardization of immunoassays of this protein have been difficult. We establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e670172322c16f67dcf8b61175fa8306
https://doi.org/10.1093/clinchem/40.7.1284
https://doi.org/10.1093/clinchem/40.7.1284
Autor:
Jeff McKee, Mark Nordhaus, Shane Donovan, Peifeng Hu, Edwin G. Moore, Edward K. Chess, Christina M. Szabo, Richard J. Johnson, Reagan Miller, Todd Wielgos, Joseph Ray, Lee Sarah, Shawn F. Bairstow, Karalyn Havel
Publikováno v:
Heparin-A Century of Progress ISBN: 9783642230554
In late 2007 and early 2008, a cluster of adverse events in patients receiving Heparin Sodium Injection occurred in the United States and in some countries in Europe. The adverse events were reported as being "allergic type" reactions, chiefly charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bcc0781f3cb5eeae382d843841bb891
https://doi.org/10.1007/978-3-642-23056-1_6
https://doi.org/10.1007/978-3-642-23056-1_6
Autor:
Barrett E. Rabinow, Edward K. Chess, Lakshmy M. Nair, Melnick Bennett, G. Joseph Ray, Edwin G. Moore, Christina M. Szabo, Lee Sarah, Reagan Miller
Publikováno v:
Analytical and bioanalytical chemistry. 399(2)
This article addresses the identification and quantification of the chemical species resulting in resonances at 2.17 and 2.25 ppm in the (1)H nuclear magnetic resonance (NMR) spectrum of pharmaceutical-grade heparin sodium. The NMR signals in questio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d3158f5b7cbcde52ca9f8335599fb4
https://pubmed.ncbi.nlm.nih.gov/20949261
https://pubmed.ncbi.nlm.nih.gov/20949261