Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Edwin F. E. de Haas"'
Autor:
Edwin F. E. de Haas, Jolanda. J. D. de Roo, Sandra A. Vloemans, Frank J. T. Staal, Brigitta A.E. Naber, Annelies M. A. van der Laan
Publikováno v:
Journal of Visualized Experiments. JOURNAL OF VISUALIZED EXPERIMENTS
ISSUE=175;TITLE=Journal of Visualized Experiments
ISSUE=175;TITLE=Journal of Visualized Experiments
Measuring Wnt expression levels is essential when trying to identify or test new Wnt therapeutic targets. Previous studies have shown that canonical Wnt signaling operates via a dosage-driven mechanism, motivating the need to study and measure Wnt si
Autor:
Jolanda. J. D. de Roo, Frank J. T. Staal, Edwin F. E. de Haas, Hans Vrolijk, Sandra A. Vloemans
Publikováno v:
Future Science OA
Hematopoietic stem cells maintain the homeostasis of all blood cell progeny during development and repopulation-demanding events. To study the lineage relationships during hematopoiesis, increasingly complex cell tracing models are being developed. I
Autor:
Edwin F. E. de Haas, J. Sjef Verbeek, Ferry Ossendorp, Leendert A. Trouw, Nataschja I Ho, Marcel Camps
Publikováno v:
Journal of Immunology, 198(11), 4235-4243
Dendritic cells (DCs) are specialized in Ag engulfment via a wide variety of uptake receptors on their cell surface. In the present study we investigated Ag uptake and presentation of in vivo–formed Ag–Ab complexes by i.v. injecting mice with Ag-
Publikováno v:
European Journal of Immunology, 48(7), 1164-1173
European Journal of Immunology
European Journal of Immunology
An exclusive feature of dendritic cells (DCs) is their ability to cross‐present exogenous antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen presenting cell (APC) subsets after uptake of naturally formed antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34319252c6681df3d76d0935aba7878
http://hdl.handle.net/1887/86720
http://hdl.handle.net/1887/86720
Autor:
Frank J. T. Staal, Martijn H. Brugman, Riccardo Fodde, Tiago C. Luis, Brigitta A.E. Naber, Jacques J.M. van Dongen, Paul P.C. Roozen, Willem E. Fibbe, Mehrnaz Ghazvini, Edwin F. E. de Haas
Publikováno v:
Cell Stem Cell, 9(4), 345-356. Cell Press
Cell Stem Cell, 9(4), 345-56
Cell Stem Cell, 9(4), 345-356
Cell Stem Cell, 9(4), 345-56
Cell Stem Cell, 9(4), 345-356
SummaryCanonical Wnt signaling has been implicated in the regulation of hematopoiesis. By employing a Wnt-reporter mouse, we observed that Wnt signaling is differentially activated during hematopoiesis, suggesting an important regulatory role for spe
Autor:
Claudia Ribeiro de Almeida, Marjan van Meurs, Jan Piet van Hamburg, Janneke N. Samsom, Rudi W. Hendriks, Louis Boon, Marjolein J. W. de Bruijn, Edwin F. E. de Haas, Marloes van Zwam
Publikováno v:
European journal of immunology, 38(9), 2573-2586. Wiley-VCH Verlag
European Journal of Immunology, 38, 2573-2586. Wiley-VCH
European Journal of Immunology, 38, 2573-2586. Wiley-VCH
The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development. Here, we investigated how GATA3 affects T
Autor:
Martijn H. Brugman, Willem A. Dik, Gerard Wagemaker, Edwin F. E. de Haas, Floor Weerkamp, Miranda R. M. Baert, Trudi P. Visser, Jacques J.M. van Dongen, Christianne J.M. de Groot, Frank J. T. Staal
Publikováno v:
Blood, 107(8), 3131-3137. American Society of Hematology
It is a longstanding question which bone marrow–derived cell seeds the thymus and to what level this cell is committed to the T-cell lineage. We sought to elucidate this issue by examining gene expression, lineage potential, and self-renewal capaci
Autor:
Floor Weerkamp, Marcel J. T. Reinders, Esther E. L. Koster, Jacques J.M. van Dongen, Anton W. Langerak, Willem A. Dik, Peter J. van der Spek, Miranda R. M. Baert, Dick de Ridder, Karin Pike-Overzet, Frank J. T. Staal, Edwin F. E. de Haas
Publikováno v:
Journal of Experimental Medicine, 201(11), 1715-1723. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
To gain more insight into initiation and regulation of T cell receptor (TCR) gene rearrangement during human T cell development, we analyzed TCR gene rearrangements by quantitative PCR analysis in nine consecutive T cell developmental stages, includi
Autor:
Miranda R. M. Baert, Edwin F. E. de Haas, Frank J. T. Staal, Mascha van Noort, Jacques J.M. van Dongen, Caroline M. M. van den Burg, Floor Weerkamp
Publikováno v:
The Journal of Immunology. 172:1099-1108
The thymus is seeded by very small numbers of progenitor cells that undergo massive proliferation before differentiation and rearrangement of TCR genes occurs. Various signals mediate proliferation and differentiation of these cells, including Wnt si
Autor:
Floor Weerkamp, Brigitta A.E. Naber, Jacques J.M. van Dongen, Frank J. T. Staal, Tatjana Nikolic, Miranda R. M. Baert, Sjanneke Heuvelmans, Tiago C. Luis, Edwin F. E. de Haas, Ronald R. de Krijger
Publikováno v:
Blood, 113(3), 546-554. American Society of Hematology
Canonical Wnt signaling has been implicated in various aspects of hematopoiesis. Its role is controversial due to different outcomes between various inducible Wnt-signaling loss-of-function models and also compared with gain-of-function systems. We t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f616a78129c8196bdd5c48e3c64be1
https://pure.eur.nl/en/publications/ba085094-2018-4672-87ac-91f8642ff0ba
https://pure.eur.nl/en/publications/ba085094-2018-4672-87ac-91f8642ff0ba