Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Edwin Chen"'
Autor:
Edwin Chen, Marla G. Shaffer, Robert E. Bilodeau, Raymond E. West, Patrick J. Oberly, Thomas D. Nolin, Matthew J. Culyba
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein. Rel synthesizes (p)ppGpp “alarmones” in response to amino acid star
Externí odkaz:
https://doaj.org/article/0a7a625521164b85a2f0eb26f6ff9117
Autor:
Zuzana Tothova, Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie Holmes, Catherine C. Landers, J. Erika Haydu, Edyta Malolepsza, Christina Hartigan, Melanie Donahue, Katerina D. Popova, Sebastian Koochaki, Sergey V. Venev, Jeanne Rivera, Edwin Chen, Kasper Lage, Monica Schenone, Alan D. D’Andrea, Steven A. Carr, Elizabeth A. Morgan, Job Dekker, Benjamin L. Ebert
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myelo
Externí odkaz:
https://doaj.org/article/04d99d4ec50c41c1a8bc57f790a16758
Autor:
Vasileios Kargas, Pablo Castro-Hartmann, Norberto Escudero-Urquijo, Kyle Dent, Christine Hilcenko, Carolin Sailer, Gertrude Zisser, Maria J Marques-Carvalho, Simone Pellegrino, Leszek Wawiórka, Stefan MV Freund, Jane L Wagstaff, Antonina Andreeva, Alexandre Faille, Edwin Chen, Florian Stengel, Helmut Bergler, Alan John Warren
Publikováno v:
eLife, Vol 8 (2019)
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how integration o
Externí odkaz:
https://doaj.org/article/68e853793d0c4ab19d7cce1b81cf73da
Autor:
Edwin Chen, Jong Sook Ahn, David B. Sykes, Lawrence J. Breyfogle, Anna L. Godfrey, Jyoti Nangalia, Amy Ko, Daniel J. DeAngelo, Anthony R. Green, Ann Mullally
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2345-2352 (2015)
JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability. In this study, we address
Externí odkaz:
https://doaj.org/article/3c30e3d78d034f9a92f3d3750be37bad
Autor:
Anna L. Godfrey, Edwin Chen, Charles E. Massie, Yvonne Silber, Francesca Pagano, Beatriz Bellosillo, Paola Guglielmelli, Claire N. Harrison, John T. Reilly, Frank Stegelmann, Fontanet Bijou, Eric Lippert, Jean-Michel Boiron, Konstanze Döhner, Alessandro M. Vannucchi, Carlos Besses, Anthony R. Green
Publikováno v:
Haematologica, Vol 101, Iss 1 (2016)
Externí odkaz:
https://doaj.org/article/f7c4fd6dbc7a4646b7a2fe6c74bbcf93
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 3, Pp 311-317 (2011)
In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs). Since this discovery, much effort has been dedicated to understandin
Externí odkaz:
https://doaj.org/article/1473835664054d78b6cbee62dedd101a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003644 (2015)
The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine developme
Externí odkaz:
https://doaj.org/article/b0b020a0c0d3442b94deda2c20c590ea
Autor:
Konstantin Krutikov, Yanzhen Zheng, Alden Chesney, Xiaoyong Huang, Andrea K Vaags, Valentina Evdokimova, Margaret R Hough, Edwin Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89649 (2014)
The noncluster homeobox gene HOX11/TLX1 (TLX1) is detected at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in patients with T cell acute lymphoblastic leukemia (T-ALL). This translocation results in the inappropriate expression of
Externí odkaz:
https://doaj.org/article/d4093994f8354e139ac437ecf8a0a81d
Autor:
Anna L. Godfrey, Edwin Chen, Francesca Pagano, Yvonne Silber, Peter J. Campbell, Anthony R. Green
Publikováno v:
Haematologica, Vol 98, Iss 5 (2013)
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear. We genotyped 4564 erythroid colonies from 59 patients wit
Externí odkaz:
https://doaj.org/article/0958de92e9b04d2da1b0e421ce5d1505
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003390 (2013)
Disrupting erythrocyte invasion by Plasmodium falciparum is an attractive approach to combat malaria. P. falciparum EBA-175 (PfEBA-175) engages the host receptor Glycophorin A (GpA) during invasion and is a leading vaccine candidate. Antibodies that
Externí odkaz:
https://doaj.org/article/6ba0ccc5583442c8813124c3557cd6e0