Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Edwin Carter"'
Autor:
Stéphanie Chhun, Yanick J. Crow, Henna Tyynismaa, Bert Callewaert, Gillian I. Rice, Manju A Kurian, Christine Bodemer, Edwin Carter, Lien De Somer, Luis Seabra, Simon Holden, Hugh J. McMillan, Brigitte Bader-Meunier, Kristin Suetens, Timothy Wai, Lucy Grove, Sylvie Fraitag, Erika Della Mina, Ashish Dhir, Fran Faes, Marie Hully, Mathieu P Rodero, Pascale de Lonlay, Marie-Louise Frémond, Alice Lepelley, Daniela Buhas, David A. Dyment, Carine Wouters, Erika Van Nieuwenhove, Lise Waumans
Publikováno v:
Lepelley, A, Mina, E D, Nieuwenhove, E V, Waumans, L, Fraitag, S, Rice, G I, Dhir, A, Frémond, M-L, Rodero, M P, Seabra, L, Carter, E, Bodemer, C, Buhas, D, Callewaert, B, Lonlay, P D, Somer, L D, Dyment, D A, Faes, F, Grove, L, Holden, S, Hully, M, Kurian, M A, McMillan, H J, Suetens, K, Tyynismaa, H, Chhun, S, Wai, T, Wouters, C, Bader-Meunier, B & Crow, Y J 2021, ' Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A ', Journal of Experimental Medicine, vol. 218, no. 10, e20201560 . https://doi.org/10.1084/jem.20201560
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Journal of Experimental Medicine, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Lepelley, A, Della Mina, E, Van Nieuwenhove, E, Waumans, L, Fraitag, S, Rice, G I, Dhir, A, Frémond, M-L, Rodero, M P, Seabra, L, Carter, E, Bodemer, C, Buhas, D, Callewaert, B, de Lonlay, P, De Somer, L, Dyment, D A, Faes, F, Grove, L, Holden, S, Hully, M, Kurian, M A, McMillan, H J, Suetens, K, Tyynismaa, H, Chhun, S, Wai, T, Wouters, C, Bader-Meunier, B & Crow, Y J 2021, ' Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20201560
JOURNAL OF EXPERIMENTAL MEDICINE
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Journal of Experimental Medicine, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Lepelley, A, Della Mina, E, Van Nieuwenhove, E, Waumans, L, Fraitag, S, Rice, G I, Dhir, A, Frémond, M-L, Rodero, M P, Seabra, L, Carter, E, Bodemer, C, Buhas, D, Callewaert, B, de Lonlay, P, De Somer, L, Dyment, D A, Faes, F, Grove, L, Holden, S, Hully, M, Kurian, M A, McMillan, H J, Suetens, K, Tyynismaa, H, Chhun, S, Wai, T, Wouters, C, Bader-Meunier, B & Crow, Y J 2021, ' Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20201560
JOURNAL OF EXPERIMENTAL MEDICINE
Mitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian mitochondrial disease. We initially ascertained two patients, one with a purel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535a86644148a93958b751d60959fb97
https://pure.manchester.ac.uk/ws/files/211719510/jem_20201560.pdf
https://pure.manchester.ac.uk/ws/files/211719510/jem_20201560.pdf
Autor:
Neil R. Johnston, Nicholas L. Mills, David J. Webb, Anoop S V Shah, Eve Miller-Hodges, Fiona E. Strachan, Edwin Carter, Neeraj Dhaun, Tariq E. Farrah, Atul Anand
Publikováno v:
Nephrology Dialysis Transplantation
Research Letter
Autor:
David A. Dyment, Stéphanie Chhun, Carine Wouters, Kristin Suetens, Hugh J. McMillan, Manju A. Kurian, P. de Lonlay, Gillian I. Rice, Bert Callewaert, Lise Waumans, Christine Bodemer, L. De Somer, E. Della Mina, F. Faes, Edwin Carter, S. Holden, Luis Seabra, E. van Nieuwenhove, Brigitte Bader-Meunier, Lucy Grove, Sylvie Fraitag, Yanick J. Crow, Marie-Louise Frémond, Timothy Wai, Ashish Dhir, Marie Hully, Daniela Buhas, Alice Lepelley, Henna Tyynismaa, Mathieu P Rodero
Mitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian mitochondrial disease. We initially ascertained two patients, one with a purel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b0f58839ccd53fadefafafb98d9d0a
https://doi.org/10.1101/2021.04.02.438201
https://doi.org/10.1101/2021.04.02.438201
Autor:
Edwin Carter, David J. Webb, Nicholas L. Mills, James W. Dear, Robert Kimmitt, Tariq E. Farrah, Peter J. Gallacher, Neeraj Dhaun, Atul Anand
Publikováno v:
Farrah, T E, Anand, A, Gallacher, P J, Kimmitt, R, Carter, E, Dear, J W, Mills, N L, Webb, D J & Dhaun, N 2019, ' Endothelin Receptor Antagonism Improves Lipid Profiles and Lowers PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) in Patients With Chronic Kidney Disease ', Hypertension, vol. 74, no. 2, pp. 323-330 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12919
Hypertension (Dallas, Tex. : 1979)
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
Dyslipidemia is common in chronic kidney disease (CKD). Despite statins, many patients fail to adequately lower lipids and remain at increased risk of cardiovascular disease. Selective ETA (
Dyslipidemia is common in chronic kidney disease (CKD). Despite statins, many patients fail to adequately lower lipids and remain at increased risk of cardiovascular disease. Selective ETA (
Autor:
Alice Hadchouel, Odile Boespflug-Tanguy, Eric Jeziorski, Thomas Blauwblomme, Buthaina Al Adba, Alice Lepelley, Isabelle Desguerre, Gillian I. Rice, Edwin Carter, Véronique Hentgen, Christine Bodemer, Lorenzo Lodi, Sandrine Passemard, Yanick J. Crow, Marie Hully, Fanny Mochel, Camille Ducrocq, Magalie Barth, Jay Shetty, Brigitte Bader-Meunier, Isabelle Melki, Florence Renaldo, Vincent Bondet, Miguel Hie, Marie Pouletty, Russell C. Dale, Romain Lévy, Pierre Ellul, Simona Orcesi, Bénédicte Neven, Cécile Dumaine, Luis Seabra, Darragh Duffy, Fabienne Dulieu, Marie-Louise Frémond, Stéphane Blanche, Rainer Seidl, Maria José Martin-Niclos, Pierre Quartier
Publikováno v:
Journal of Clinical Immunology
Journal of Clinical Immunology, 2021, 41 (3), pp.603-609. ⟨10.1007/s10875-020-00952-x⟩
Journal of Clinical Immunology, Springer Verlag, 2021, 41 (3), pp.603-609. ⟨10.1007/s10875-020-00952-x⟩
Lodi, L, Melki, I, Bondet, V, Seabra, L, Rice, G I, Carter, E, Lepelley, A, Martin-Niclós, M J, Al Adba, B, Bader-Meunier, B, Barth, M, Blauwblomme, T, Bodemer, C, Boespflug-Tanguy, O, Dale, R C, Desguerre, I, Ducrocq, C, Dulieu, F, Dumaine, C, Ellul, P, Hadchouel, A, Hentgen, V, Hié, M, Hully, M, Jeziorski, E, Lévy, R, Mochel, F, Orcesi, S, Passemard, S, Pouletty, M, Quartier, P, Renaldo, F, Seidl, R, Shetty, J, Neven, B, Blanche, S, Duffy, D, Crow, Y J & Frémond, M-L 2021, ' Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies ', Journal of clinical immunology, vol. 41, no. 3, pp. 603-609 . https://doi.org/10.1007/s10875-020-00952-x
Lodi, L, Melki, I, Bondet, V, Seabra, L, Rice, G I, Carter, E, Lepelley, A, Martin-Niclos, M J, Al Adba, B, Bader-Meunier, B, Barth, M, Blauwblomme, T, Bodemer, C, Boespflug-tanguy, O, Dale, R C, Desguerre, I, Ducrocq, C, Dulieu, F, Dumaine, C, Ellul, P, Hadchouel, A, Hentgen, V, Hié, M, Hully, M, Jeziorski, E, Lévy, R, Mochel, F, Orcesi, S, Passemard, S, Pouletty, M, Quartier, P, Renaldo, F, Seidl, R, Shetty, J, Neven, B, Blanche, S, Duffy, D, Crow, Y J & Frémond, M-L 2021, ' Differential expression of interferon alpha protein provides clues to tissue specificity across type I interferonopathies ', Journal of Clinical Immunology . https://doi.org/10.1007/s10875-020-00952-x
Journal of Clinical Immunology, 2021, 41 (3), pp.603-609. ⟨10.1007/s10875-020-00952-x⟩
Journal of Clinical Immunology, Springer Verlag, 2021, 41 (3), pp.603-609. ⟨10.1007/s10875-020-00952-x⟩
Lodi, L, Melki, I, Bondet, V, Seabra, L, Rice, G I, Carter, E, Lepelley, A, Martin-Niclós, M J, Al Adba, B, Bader-Meunier, B, Barth, M, Blauwblomme, T, Bodemer, C, Boespflug-Tanguy, O, Dale, R C, Desguerre, I, Ducrocq, C, Dulieu, F, Dumaine, C, Ellul, P, Hadchouel, A, Hentgen, V, Hié, M, Hully, M, Jeziorski, E, Lévy, R, Mochel, F, Orcesi, S, Passemard, S, Pouletty, M, Quartier, P, Renaldo, F, Seidl, R, Shetty, J, Neven, B, Blanche, S, Duffy, D, Crow, Y J & Frémond, M-L 2021, ' Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies ', Journal of clinical immunology, vol. 41, no. 3, pp. 603-609 . https://doi.org/10.1007/s10875-020-00952-x
Lodi, L, Melki, I, Bondet, V, Seabra, L, Rice, G I, Carter, E, Lepelley, A, Martin-Niclos, M J, Al Adba, B, Bader-Meunier, B, Barth, M, Blauwblomme, T, Bodemer, C, Boespflug-tanguy, O, Dale, R C, Desguerre, I, Ducrocq, C, Dulieu, F, Dumaine, C, Ellul, P, Hadchouel, A, Hentgen, V, Hié, M, Hully, M, Jeziorski, E, Lévy, R, Mochel, F, Orcesi, S, Passemard, S, Pouletty, M, Quartier, P, Renaldo, F, Seidl, R, Shetty, J, Neven, B, Blanche, S, Duffy, D, Crow, Y J & Frémond, M-L 2021, ' Differential expression of interferon alpha protein provides clues to tissue specificity across type I interferonopathies ', Journal of Clinical Immunology . https://doi.org/10.1007/s10875-020-00952-x
International audience; Whilst upregulation of type I interferon (IFN) signaling is common across the type I interferonopathies (T1Is), central nervous system (CNS) involvement varies between these disorders, the basis of which remains unclear. We co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14739d424dc89b8b397326fdee8ff2a6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03236262
https://hal-pasteur.archives-ouvertes.fr/pasteur-03236262
Autor:
Lucy Bizien, Eystein S. Husebye, Edwin Carter, Maria Pavlova, Jérémie Rosain, Fanny Vuoto, Bénédicte Neven, Thomas DiMaggio, Monica M. Schmitt, Agnès Linglart, Luigi D. Notarangelo, Kai Kisand, Adrian Gervais, Michail S. Lionakis, Mark S. Anderson, Olov Ekwall, Nathalie Cheikh, Sébastien Humbert, Yulia Rodina, Olivier Hermine, Pierre Rohrlich, Lucia Ghizzoni, Romain Lévy, Anya Rothenbuhler, Tom Le Voyer, Paul Bastard, Laurent Abel, Brigite Mignot, Anna-Lena Neehus, Sebastian Ochoa, Steven M. Holland, Helen C. Su, Quentin Philippot, Emmanuelle Jouanguy, Karine Faure, Martin Mcintyre, Mélanie Migaud, Elana Shaw, Maria Kareva, Arthur Pavot, Aurélie Comte, Nelli Y Kann, Elise M. N. Ferré, Anna Shcherbina, Katarina Trebušak Podkrajšek, Alyssa James, Leila S. Sozaeva, Lars Breivik, Yanick J. Crow, Primož Kotnik, Guglielmo Beccuti, Stefan Berg, Nizar Mahlaoui, Tadej Battelino, Gérard Thiriez, Anne Puel, Alain Coaquette, Cécile Goujard, Marie-Louise Frémond, Shen-Ying Zhang, Jean-Laurent Casanova, Lindsey B. Rosen, Peter D. Burbelo, Anna Kolodkina, Elizaveta Orlova
Publikováno v:
e20210554
Journal of Experimental Medicine (JEM)
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 218, iss 7
Journal of Experimental Medicine (JEM)
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 218, iss 7
Patients with autoimmune polyendocrine syndrome type-1 (APS-1) have circulating auto-Abs neutralizing most type I interferons. These auto-Abs can underlie life-threatening COVID-19 pneumonia in the general population. The authors report 22 APS-1 pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e661f163f19fcd714b01b00e152c1b
https://hdl.handle.net/11250/2991631
https://hdl.handle.net/11250/2991631
Autor:
Graham P. Taylor, Ashley Sanchez Sevilla Uruchurtu, Malcolm G Semple, Felicity Liew, Thilipan Thaventhiran, Emma Bergstrom, Shona C Moore, Clark D Russell, Charlotte-Eve Short, Peter J. M. Openshaw, Yanick J. Crow, Matthew K. Siggins, Annemarie B Docherty, David M. Hunt, Simon T. Abrams, Ewen M Harrison, Stephanie Ascough, Christopher Chiu, J Kenneth Baillie, Zoe Gardener, Edwin Carter, Tom Solomon, Ryan S Thwaites, Lance Turtle
Introductory paragraphThe mechanisms that underpin COVID-19 disease severity, and determine the outcome of infection, are only beginning to be unraveled. The host inflammatory response contributes to lung injury, but circulating mediators levels fall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ea3fe48ea904588f3e75fc41ea4a4b
https://doi.org/10.1101/2020.10.08.20209411
https://doi.org/10.1101/2020.10.08.20209411
Autor:
Nicolas Manel, Siham Boulisfane-El Khalifi, Mary Brennan, Darragh Duffy, Nadia Nathan, Serge Amselem, Kathryn J. McKenzie, Maria José Martin-Niclos, Jonny Hertzog, Carolina Uggenti, Marie Legendre, Stéphanie Chhun, Caroline Thumerelle, Luis Seabra, Marie-Louise Frémond, Vincent Bondet, Bénédicte Neven, Joseph A. Marsh, Marie Wislez, Catherine McDougall, Marine Depp, Jan Rehwinkel, Gillian I. Rice, Aurore Coulomb L'Hermine, Yanick J. Crow, Lucienne Chatenoud, Melvin Le Bihan, Thierry Jo Molina, Karen J. Mackenzie, Alice Lepelley, Edwin Carter, Jonathan Marey
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (11), pp.e20200600. ⟨10.1084/jem.20200600⟩
Journal of Experimental Medicine, 2020, 217 (11), pp.e20200600. ⟨10.1084/jem.20200600⟩
Lepelley, A, Martin-niclós, M J, Le Bihan, M, Marsh, J A, Uggenti, C, Rice, G I, Bondet, V, Duffy, D, Hertzog, J, Rehwinkel, J, Amselem, S, Boulisfane-el Khalifi, S, Brennan, M, Carter, E, Chatenoud, L, Chhun, S, Coulomb L’hermine, A, Depp, M, Legendre, M, Mackenzie, K J, Marey, J, Mcdougall, C, Mckenzie, K J, Molina, T J, Neven, B, Seabra, L, Thumerelle, C, Wislez, M, Nathan, N, Manel, N, Crow, Y J & Frémond, M 2020, ' Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling ', Journal of Experimental Medicine, vol. 217, no. 11 . https://doi.org/10.1084/jem.20200600
Lepelley, A, Martin-Niclos, M J, Le Bihan, M, Marsh, J A, Uggenti, C, Rice, G I, Bondet, V, Duffy, D, Hertzog, J, Rehwinkel, J, Amselem, S, Boulisfane-El Khalifi, S, Brennan, M, Carter, E, Chatenoud, L, Chhun, S, l'Hermine, A C, Depp, M, Legendre, M, Mackenzie, K J, Marey, J, McDougall, C, McKenzie, K J, Molina, T J, Neven, B, Seabra, L, Thumerelle, C, Wislez, M, Nathan, N, Manel, N, Crow, Y J & Fremond, M-L 2020, ' Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling ', Journal of Experimental Medicine, vol. 217, no. 11 . https://doi.org/10.1084/jem.20200600
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (11), pp.e20200600. ⟨10.1084/jem.20200600⟩
Journal of Experimental Medicine, 2020, 217 (11), pp.e20200600. ⟨10.1084/jem.20200600⟩
Lepelley, A, Martin-niclós, M J, Le Bihan, M, Marsh, J A, Uggenti, C, Rice, G I, Bondet, V, Duffy, D, Hertzog, J, Rehwinkel, J, Amselem, S, Boulisfane-el Khalifi, S, Brennan, M, Carter, E, Chatenoud, L, Chhun, S, Coulomb L’hermine, A, Depp, M, Legendre, M, Mackenzie, K J, Marey, J, Mcdougall, C, Mckenzie, K J, Molina, T J, Neven, B, Seabra, L, Thumerelle, C, Wislez, M, Nathan, N, Manel, N, Crow, Y J & Frémond, M 2020, ' Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling ', Journal of Experimental Medicine, vol. 217, no. 11 . https://doi.org/10.1084/jem.20200600
Lepelley, A, Martin-Niclos, M J, Le Bihan, M, Marsh, J A, Uggenti, C, Rice, G I, Bondet, V, Duffy, D, Hertzog, J, Rehwinkel, J, Amselem, S, Boulisfane-El Khalifi, S, Brennan, M, Carter, E, Chatenoud, L, Chhun, S, l'Hermine, A C, Depp, M, Legendre, M, Mackenzie, K J, Marey, J, McDougall, C, McKenzie, K J, Molina, T J, Neven, B, Seabra, L, Thumerelle, C, Wislez, M, Nathan, N, Manel, N, Crow, Y J & Fremond, M-L 2020, ' Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling ', Journal of Experimental Medicine, vol. 217, no. 11 . https://doi.org/10.1084/jem.20200600
International audience; Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome overlapping clinically with type I IFN-mediated disease due to gain-of-function in STING, a key adaptor of IFN signaling. Recently, increas
Publikováno v:
Energy Efficiency. 12:5-17
In homes in the UK, it is very common to operate space heating intermittently; the heating is usually switched off when the occupants are asleep at night and when they are out during the day. The strong association between heating operation and house