Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Edwin C Thrower"'
Autor:
Padmanabhan Srinivasan, Edwin C Thrower, Gopalakrishnan Loganathan, A N Balamurugan, Veedamali S Subramanian, Fred S Gorelick, Hamid M Said
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143575 (2015)
Thiamin (vitamin B1), a member of the water-soluble family of vitamins, is essential for normal cellular functions; its deficiency results in oxidative stress and mitochondrial dysfunction. Pancreatic acinar cells (PAC) obtain thiamin from the circul
Externí odkaz:
https://doaj.org/article/33fe69f587404d28beac8550b1b3e8c0
Autor:
Thomas R Kolodecik, Christine A Shugrue, Edwin C Thrower, Lonny R Levin, Jochen Buck, Fred S Gorelick
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41320 (2012)
An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen a
Externí odkaz:
https://doaj.org/article/b86bb9574ccb44619b53e44daa82011a
Autor:
E. O. Akinbiyi, Christine A. Shugrue, Scott W. Messenger, M Ashat, Abdul Kareem Uduman, Edwin C. Thrower, Guy E. Groblewski, B Sreekumar, Fred S. Gorelick, N Tashkandi, Martine Alexandre, Vikhil Patel, Abdulrahman A. Alahmari, Tom Kolodecik, A Ceplenski
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0197362 (2018)
PLoS ONE, Vol 13, Iss 6, p e0197362 (2018)
Clinical studies have shown that cigarette smoking is a dose-dependent and independent risk factor for acute pancreatitis. Cigarette smoke contains nicotine which can be converted to the potent receptor ligand and toxin, NNK [4-(methylnitrosamino)-1-
Autor:
Rebecca Patton, Mohamed Shitia, Samantha N. Minervini, Thomas R. Kolodecik, Abdul Kareem Uduman, E. O. Akinbiyi, Edwin C. Thrower, Martine Alexandre, Fred S. Gorelick, Vikhil Patel, Christine A. Shugrue, Ali Raoof
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G696-G704
Clinical studies indicate that cigarette smoking increases the risk for developing acute pancreatitis. The nicotine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a major cigarette smoke toxin. We hypothesized that NNK could sensi
Autor:
Martine Alexandre, Alexander P. E. Diaz de Villalvilla, Fred S. Gorelick, Edwin C. Thrower, Thomas R. Kolodecik, Christine A. Shugrue, Lawrence H. Young
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G723-G732
The premature activation of digestive enzyme zymogens in the pancreatic acinar cell is an important initiating event in acute pancreatitis. We have previously demonstrated that vacuolar ATPase (vATPase) activity is required for zymogen activation. Ad
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 310(10)
Thiamin is essential for normal metabolism in pancreatic acinar cells (PAC) and is obtained from their microenvironment through specific plasma-membrane transporters, converted to thiamin pyrophosphate (TPP) in the cytoplasm, followed by uptake of TP
Autor:
Appakalai N. Balamurugan, Fred S. Gorelick, Gopalakrishnan Loganathan, Veedamali S. Subramanian, Edwin C. Thrower, Hamid M. Said, Padmanabhan Srinivasan
Publikováno v:
Srinivasan, P; Thrower, EC; Loganathan, G; Balamurugan, AN; Subramanian, VS; Gorelick, FS; et al.(2015). Chronic nicotine exposure in vivo and in vitro inhibits vitamin B1 (Thiamin) uptake by pancreatic acinar cells. PLoS ONE, 10(12). doi: 10.1371/journal.pone.0143575. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6cn61607
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0143575 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0143575 (2015)
© 2015 Srinivasan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaf8f227d90fd83cbbed87da4d717de
http://www.escholarship.org/uc/item/6cn61607
http://www.escholarship.org/uc/item/6cn61607
Publikováno v:
Open Access Animal Physiology. 1:1-11
Thomas Kolodecik1,3, Fred Gorelick1–3, Edwin Thrower1,31Department of Internal Medicine, Section of Digestive Diseases, 2Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; 3Veterans Administration Connecticut Health
Autor:
Fred S. Gorelick, Edwin C. Thrower
Publikováno v:
Clinical Gastroenterology and Hepatology. 7:S10-S14
Pathologic responses arising from the pancreatic acinar cell appear to have a central role in initiating acute pancreatitis. Environmental factors that sensitize the acinar cell to harmful stimuli likely have a critical role in many forms of pancreat
Autor:
Jingzhen Yuan, Fred S. Gorelick, Jeffrey Wang, Aurelia Lugea, Thomas R. Kolodecik, Joseph R. Reeve, Edwin C. Thrower, Salim Cheriyan, Stephen J. Pandol
Publikováno v:
Pancreas. 38:930-935
To define the role of protein kinase C delta (PKC delta) in acinar cell responses to the hormone cholecystokinin-8 (CCK) using isoform-specific inhibitors and a previously unreported genetic deletion model.Pancreatic acinar cells were isolated from (