Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edwin Arauz"'
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1510-1517 (2016)
Amino acid availability activates signaling by the mammalian target of rapamycin (mTOR) complex 1, mTORC1, a master regulator of cell growth. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocatio
Externí odkaz:
https://doaj.org/article/98d968ffbba84cddbe3957606183cc0f
Publikováno v:
Revista Médico Científica. 35:23-30
El daño hepático inducido por medicamentos representa una causa frecuente de falla hepática aguda y engloba una serie de reacciones asociadas a daño directo de las células hepáticas mediante mecanismos inmunes o reacciones idiosincráticas. Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd78a6e97e835f4dff1a72e8929a619
https://doi.org/10.37416/rmc.v35i1.740
https://doi.org/10.37416/rmc.v35i1.740
Autor:
Fernando Pérez, Edwin Arauz Valdes
Publikováno v:
Revista Médico Científica. 33:67-88
La pancreatitis aguda es una de las principales causas gastrointestinales por la cual se acude al cuarto de urgencias, y es una causa importante de morbimortalidad a nivel mundial. Se caracteriza por la activación desmedida de la tripsina en las cé
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e1f30bf45f1b63586cd095bc227876
https://doi.org/10.37416/rmc.v33i1.570
https://doi.org/10.37416/rmc.v33i1.570
Publikováno v:
Revista Médico Científica. 33:52-63
Antecedentes: La Diabetes Mellitus (DM) es una enfermedad metabólica de etiología diversa y alta prevalencia a nivel mundial. Se estimaron 463 millones de casos en el 2019 y su tendencia va en aumento. La metformina es el medicamento más utilizado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cd0de4ea50636f3228960a4b3a3d37
https://doi.org/10.37416/rmc.v33i1.585
https://doi.org/10.37416/rmc.v33i1.585
Autor:
Liou Y. Sun, Andrzej Bartke, Tian Zhang, Samuel McFadden, Justin Darcy, Jie Chen, Edwin Arauz, Rong Yuan, Chi Zhang, Adriana Reyes-Ordoñez, Martin A. Javors, Stuart J. Frank, John Gao, Cristal M. Hill, Yimin Fang, John J. Kopchick, Jared M. Osland
Publikováno v:
Proceedings of the National Academy of Sciences. 115
It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417ccb1b5cf7d536976086232becb2b5
https://doi.org/10.1073/pnas.1717065115
https://doi.org/10.1073/pnas.1717065115
Publikováno v:
Cell reports, vol 16, iss 6
CELL REPORTS(16): 6
Cell Reports, Vol 16, Iss 6, Pp 1510-1517 (2016)
CELL REPORTS(16): 6
Cell Reports, Vol 16, Iss 6, Pp 1510-1517 (2016)
Amino acid availability activates signaling by the mammalian target of rapamycin (mTOR) complex 1, mTORC1, a master regulator of cell growth. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f27a835e150b86e102bd9e7a398cc0c
https://escholarship.org/uc/item/8dc494v6
https://escholarship.org/uc/item/8dc494v6
Recognition of signaling phospholipids by proteins is a critical requirement for the targeting and initiation of many signaling cascades. Most biophysical methods for measuring protein interactions with signaling phospholipids use purified proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f399b19a509144a3e817f7c1f02b7d
https://europepmc.org/articles/PMC4863138/
https://europepmc.org/articles/PMC4863138/
Publikováno v:
Journal of Biological Chemistry. 286:29568-29574
Phosphatidic acid (PA) is a critical mediator of mitogenic activation of mammalian target of rapamycin complex 1 (mTORC1) signaling, a master regulator of mammalian cell growth and proliferation. The mechanism by which PA activates mTORC1 signaling h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8583c4c516843cf382cc75c9190a268f
https://doi.org/10.1074/jbc.m111.262816
https://doi.org/10.1074/jbc.m111.262816
Autor:
Biswarathan Ramani, Kaushik Ragunathan, Taekjip Ha, Ruijie Liu, Yuji Ishitsuka, Ankur Jain, Yang Kevin Xiang, Jeehae Park, Edwin Arauz, Jie Chen
Publikováno v:
Nature
Proteins perform most cellular functions in macromolecular complexes. The same protein often participates in different complexes to exhibit diverse functionality. Current ensemble approaches of identifying cellular protein interactions cannot reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d27d68ac219433b83d967424f585f37
http://europepmc.org/articles/PMC3103084
http://europepmc.org/articles/PMC3103084
Publikováno v:
ResearcherID
The mammalian target of rapamycin (mTOR) kinase is a master regulator of cellular, developmental, and metabolic processes. Deregulation of mTOR signaling is implicated in numerous human diseases including cancer and diabetes. mTOR functions as part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfb1a7e069f8bb6e3c72e683b3ce833
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000346366500053&KeyUID=CCC:000346366500053
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000346366500053&KeyUID=CCC:000346366500053