Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Edwin A. Clark"'
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Methods. Methods used to generate supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5dd7c471b7c4a1ddffa4e34676c5fd
https://doi.org/10.1158/1078-0432.22460742.v1
https://doi.org/10.1158/1078-0432.22460742.v1
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Figure 3. HGF and HGFAC expression in RCC-43b and RCC-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f11f00b55bfc75ccea62825b73a52d5
https://doi.org/10.1158/1078-0432.22460745
https://doi.org/10.1158/1078-0432.22460745
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Figure 2. MET copy number in RCC-43 tumors from passage 6 and 9, and in RCC-47 tumors from passage 5 and 10 by qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbbb4bf101ee605e52e858cb22c0777
https://doi.org/10.1158/1078-0432.22460748
https://doi.org/10.1158/1078-0432.22460748
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Purpose: Papillary renal cell carcinoma (PRCC) is the second most common cancer of the kidney and carries a poor prognosis for patients with nonlocalized disease. The HGF receptor MET plays a central role in PRCC and aberrations, either through mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b18db191e2cc5480da4aa94213967ad
https://doi.org/10.1158/1078-0432.c.6524580.v1
https://doi.org/10.1158/1078-0432.c.6524580.v1
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Figure 1. In vitro activity of AZD6094, sunitinib, crizotinib, SGX-523, JNJ3887605, PHA-665752, and INC280 in AGS and GTL16 gastric cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a34eeb2631ee98aded615fb04d44542
https://doi.org/10.1158/1078-0432.22460751.v1
https://doi.org/10.1158/1078-0432.22460751.v1
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Table 1. Genes with copy number gain in RCC-43b and RCC-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ce0febeda6413952793baa605d8702
https://doi.org/10.1158/1078-0432.22460739
https://doi.org/10.1158/1078-0432.22460739
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Table 2. Mutations in RCC-43b and RCC-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046833db021eaddc6a13dddcd7102f1c
https://doi.org/10.1158/1078-0432.22460736.v1
https://doi.org/10.1158/1078-0432.22460736.v1
Autor:
Pradip K. Majumder, Peter R. Strack, Giulio F. Draetta, Edwin A. Clark, Christopher Winter, Domenico Coppola, Timothy Yeatman, Carolyn Buser, Raymond E. Gibson, John F. Reilly, Giuseppe Mesiti, Shailendra Patel, Jennifer Tammam, Saverio Giampaoli, Timothy Sullivan, Christopher Ware, Christopher T. Winkelmann, Clay L. Efferson
Supplementary Figures 1-3, Tables 1-2 from Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ed2415b597b108860c97ced4978686
https://doi.org/10.1158/0008-5472.22386984
https://doi.org/10.1158/0008-5472.22386984
Autor:
Shak S, David J. Mauro, Christopher T. Harbison, Maddala T, Shirin Khambata-Ford, Rowinsky Ek, Li-An Xu, Baker Jb, D. Dutta, Watson D, Munneke Bm, Edwin A. Clark
Publikováno v:
British Journal of Cancer
Background: Although it is accepted that metastatic colorectal cancers (mCRCs) that carry activating mutations in KRAS are unresponsive to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, a significant fraction of KRAS wild-type (w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e075f17a43a30e1c99e9ab7c90856a
https://doi.org/10.1038/sj.bjc.6606054
https://doi.org/10.1038/sj.bjc.6606054