Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Edwin, Sandanaraj"'
Autor:
Melanie Si Yan Tan, Edwin Sandanaraj, Yuk Kien Chong, See Wee Lim, Lynnette Wei Hsien Koh, Wai Hoe Ng, Nguan Soon Tan, Patrick Tan, Beng Ti Ang, Carol Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.
Externí odkaz:
https://doaj.org/article/d61c46f20a3c44179f855b1383771751
Autor:
Beng Ti Ang, Carol Tang, Ivan Ng, Wai Hoe Ng, Greg Tucker-Kellogg, Oi Lian Kon, Siew Hong Leong, Swee Seong Wong, Mark Phong, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Esther Hui-Ling Ting, Tan Boon Toh, Felicia Soo-Lee Ng
PDF file - 688K, Supplementary Fig. S1. NNI-8 GPCs display stemness expression and extensive self-renewal.Supplementary Fig. S2. NNI-8 orthotopic xenograft recapitulates patient tumor pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703b30891d9d2694cbe9d4c67ee4df2d
https://doi.org/10.1158/1078-0432.22443275.v1
https://doi.org/10.1158/1078-0432.22443275.v1
Autor:
Beng Ti Ang, Carol Tang, Ivan Ng, Wai Hoe Ng, Greg Tucker-Kellogg, Oi Lian Kon, Siew Hong Leong, Swee Seong Wong, Mark Phong, Edwin Sandanaraj, Geraldene Rong-Hui Koh, Esther Hui-Ling Ting, Tan Boon Toh, Felicia Soo-Lee Ng
Purpose: Patient-derived glioma-propagating cells (GPC) contain karyotypic and gene expression profiles that are found in the primary tumor. However, their clinical relevance is unclear. We ask whether GPCs contribute to disease progression and survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37b35ff8e93d27a56a4853cc92c65ad
https://doi.org/10.1158/1078-0432.c.6519749
https://doi.org/10.1158/1078-0432.c.6519749
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb9f03b215b799e214de69512817fed
https://doi.org/10.1158/0008-5472.c.6502959.v1
https://doi.org/10.1158/0008-5472.c.6502959.v1
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe96a3645ea7acb872fd18ed47676d7
https://doi.org/10.1158/0008-5472.22390458
https://doi.org/10.1158/0008-5472.22390458
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 130K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baf99cb3a4d8497ec067cc57d1b906e
https://doi.org/10.1158/0008-5472.22390461.v1
https://doi.org/10.1158/0008-5472.22390461.v1
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 508K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d5663fdcdec0d4e5fc3744e2f2dfa
https://doi.org/10.1158/0008-5472.22390464.v1
https://doi.org/10.1158/0008-5472.22390464.v1
Autor:
Joanne Toh, Ling Ling Chua, Patrick Ho, Edwin Sandanaraj, Carol Tang, Hongyan Wang, Eng King Tan
Publikováno v:
Cells, Vol 10, Iss 1, p 76 (2021)
Parkinson’s disease (PD) is an age-dependent neurodegenerative condition. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most frequent cause of sporadic and autosomal dominant PD. The exact role of LRRK2 protective variants (R1398H, N551K)
Externí odkaz:
https://doaj.org/article/6f6d4e20230f45c4b9a82332ef5571e1
Autor:
Yuk Kien Chong, Edwin Sandanaraj, Beng Ti Ang, Nguan Soon Tan, Wai Hoe Ng, See Wee Lim, Melanie Si Yan Tan, Patrick Tan, Lynnette Koh, Carol Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Intratumoral heterogeneity is a hallmark of glioblastoma (GBM) tumors, thought to negatively influence therapeutic outcome. Previous studies showed that mesenchymal tumors have a worse outcome than the proneural subtype. Here we focus on STAT3 as its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92feb4b0de7efecb9670497f3496ee8c
https://doaj.org/article/d61c46f20a3c44179f855b1383771751
https://doaj.org/article/d61c46f20a3c44179f855b1383771751
Autor:
Shaomeng Wang, Yulun Huang, Ying Xu, Sigal Gery, Ruby Yu-Tong Lin, Tuan Zea Tan, Edwin Sandanaraj, See Wee Lim, John S. Yu, Kassoum Nacro, Moli Huang, Yuk Kien Chong, Anand Mayakonda, Ye Chen, Longchuan Bai, Hiroaki Wakimoto, Xin-Yu Ke, Jianxiang Chen, Liang Xu, Zhengyun Huang, Jeffrey Hill, H. Phillip Koeffler, Carol Tang, Pushkar Dakle, Beng Ti Ang, Lynnette Koh, Markus Müschen, Tseng Tsai Yeo
Publikováno v:
Science Advances
Profiling of active gene-regulatory DNA elements in brain cancer tissues illuminates disease biology and therapeutic targets.
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec6be9888aafd06c8ed01588bb0ced2
https://hdl.handle.net/10356/151048
https://hdl.handle.net/10356/151048