Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Edwin, Choy"'
Autor:
Gaylor Boulay, Liliane C. Broye, Rui Dong, Sowmya Iyer, Rajendran Sanalkumar, Yu-Hang Xing, Rémi Buisson, Shruthi Rengarajan, Beverly Naigles, Benoît Duc, Angela Volorio, Mary E. Awad, Raffaele Renella, Ivan Chebib, G. Petur Nielsen, Edwin Choy, Gregory M. Cote, Lee Zou, Igor Letovanec, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT
Externí odkaz:
https://doaj.org/article/fd00253648764577aeb52739a580a6a3
Autor:
David S. Shulman, Priscilla Merriam, Edwin Choy, Lillian M. Guenther, Kerri L. Cavanaugh, Pei‐Chi Kao, Andrew Posner, Ketki Bhushan, Grace Fairchild, Emma Barker, Kelly Klega, Kimberly Stegmaier, Brian D. Crompton, Wendy B. London, Steven G. DuBois
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15207-15216 (2023)
Abstract Background Ewing sarcoma (EWS) is an aggressive sarcoma with few treatment options for patients with relapsed disease. Cyclin‐dependent kinase 4 (CDK4) is a genomic vulnerability in EWS that is synergistic with IGF‐1R inhibition in precl
Externí odkaz:
https://doaj.org/article/87f07bdc01a54de09d41b110e52c7544
Autor:
Yunfei Liao, Slim Sassi, Stefan Halvorsen, Yong Feng, Jacson Shen, Yan Gao, Gregory Cote, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek, Zhenfeng Duan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/bfd2fe52e03f42fc801106da7e98ba2b
Autor:
Mrinal M. Gounder, Narasimhan P. Agaram, Sally E. Trabucco, Victoria Robinson, Richard A. Ferraro, Sherri Z. Millis, Anita Krishnan, Jessica Lee, Steven Attia, Wassim Abida, Alexander Drilon, Ping Chi, Sandra P. D’ Angelo, Mark A. Dickson, Mary Lou Keohan, Ciara M. Kelly, Mark Agulnik, Sant P. Chawla, Edwin Choy, Rashmi Chugh, Christian F. Meyer, Parvathi A. Myer, Jessica L. Moore, Ross A. Okimoto, Raphael E. Pollock, Vinod Ravi, Arun S. Singh, Neeta Somaiah, Andrew J. Wagner, John H. Healey, Garrett M. Frampton, Jeffrey M. Venstrom, Jeffrey S. Ross, Marc Ladanyi, Samuel Singer, Murray F. Brennan, Gary K. Schwartz, Alexander J. Lazar, David M. Thomas, Robert G. Maki, William D. Tap, Siraj M. Ali, Dexter X. Jin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and
Externí odkaz:
https://doaj.org/article/ded28dd2538e4114ba7de3e78b153f38
Autor:
Emely Möller, Viviane Praz, Sanalkumar Rajendran, Rui Dong, Alexandra Cauderay, Yu-Hang Xing, Lukuo Lee, Carlo Fusco, Liliane C. Broye, Luisa Cironi, Sowmya Iyer, Shruthi Rengarajan, Mary E. Awad, Beverly Naigles, Igor Letovanec, Nicola Ormas, Giovanna Finzi, Stefano La Rosa, Fausto Sessa, Ivan Chebib, G. Petur Nielsen, Antonia Digklia, Dimitrios Spentzos, Gregory M. Cote, Edwin Choy, Martin Aryee, Ivan Stamenkovic, Gaylor Boulay, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The relationship between cellular histogenesis and molecular phenotypes for the EWSR1- ATF1 fusion in clear cell sarcoma (CCS) requires further characterization. Here, the authors investigate the EWSR1-ATF1 gene regulation networks in CCS cell lines,
Externí odkaz:
https://doaj.org/article/1755fdc1556a4ae2aea83d025041fcd5
Autor:
Christopher E. Lietz, Erik T. Newman, Andrew D. Kelly, David H. Xiang, Ziying Zhang, Caroline A. Luscko, Santiago A. Lozano-Calderon, David H. Ebb, Kevin A. Raskin, Gregory M. Cote, Edwin Choy, G. Petur Nielsen, Benjamin Haibe-Kains, Martin J. Aryee, Dimitrios Spentzos
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)
Christopher Lietz et al. examined genome-wide methylation in patient cohorts of primary osteosarcoma. Their results suggest that genomic hypomethylation is predictive of response to standard chemotherapy, and provide further insight into clinical imp
Externí odkaz:
https://doaj.org/article/90a95b6cbfc54bdc95e1e3c7e78c0b3f
Publikováno v:
Current Treatment Options in Oncology. 24:300-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38bbbe7f40055eef2abf149745d19d0a
https://doi.org/10.1007/s11864-023-01059-2
https://doi.org/10.1007/s11864-023-01059-2
Autor:
Mark L. Kayton, Aaron R. Weiss, Wei Xue, Odion Binitie, Andrea Hayes Dixon, R. Lor Randall, Joel I. Sorger, Douglas S. Hawkins, Sheri L. Spunt, Dian Wang, Lynn Million, Stephanie Terezakis, Edwin Choy, Scott H. Okuno, Rajkumar Venkatramani, Yen‐Lin Chen, Thomas J. Scharschmidt
Publikováno v:
Journal of Surgical Oncology. 127:871-881
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2d873dc70eaf80156e5ab7b9da100b
https://doi.org/10.1002/jso.27205
https://doi.org/10.1002/jso.27205
Autor:
Matthew Ingham, Shing Lee, Brian A. Van Tine, Edwin Choy, Jay Oza, Sahil Doshi, Liner Ge, Peter Oppelt, Gregory Cote, Brian Corgiat, Naomi Sender, Sarah Sta Ana, Lavan Panchalingam, Emmanuel Petricoin, Gary K. Schwartz
Publikováno v:
Clinical Cancer Research. 29:1031-1039
Purpose:To evaluate sitravatinib, an inhibitor of multiple receptor tyrosine kinases (RTK), for the treatment of well-differentiated/dedifferentiated liposarcoma (WD/DD LPS).Patients and Methods:This multicenter, open-label, Phase II trial enrolled p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bac99e89011fb38f238ee577416a9f06
https://doi.org/10.1158/1078-0432.ccr-22-3351
https://doi.org/10.1158/1078-0432.ccr-22-3351
Autor:
Jacob Engellau, Leanne Seeger, Robert Grimer, Robert Henshaw, Hans Gelderblom, Edwin Choy, Sant Chawla, Peter Reichardt, Michael O’Neal, Amy Feng, Ira Jacobs, Zachary J. Roberts, Ada Braun, Bruce A. Bach
Publikováno v:
World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is
Externí odkaz:
https://doaj.org/article/68795b5d42b14e8ebc8008677013379f