Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Edwin, Chen"'
Autor:
Edwin Chen, Marla G. Shaffer, Robert E. Bilodeau, Raymond E. West, Patrick J. Oberly, Thomas D. Nolin, Matthew J. Culyba
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein. Rel synthesizes (p)ppGpp “alarmones” in response to amino acid star
Externí odkaz:
https://doaj.org/article/0a7a625521164b85a2f0eb26f6ff9117
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Proper axonal branch growth and targeting are essential for establishing a hard-wired neural circuit. Here, we examined the role of Fibroblast Growth Factor Receptors (FGFRs) in axonal arbor development using loss of function and overexpress
Externí odkaz:
https://doaj.org/article/fda0c2d4db584b40824a3eb153eb3bf7
Autor:
Ibrahim Kays, Brian Edwin Chen
Publikováno v:
BioTechniques, Vol 66, Iss 1, Pp 15-21 (2019)
Single-cell analysis overcomes the problems of cellular heterogeneity by revealing the individual differences between cells in tissue. The current tools used to profile gene expression at the single-cell level are arduous and often require specialize
Externí odkaz:
https://doaj.org/article/0ef6b081b4de44fda9a8594f08c5ef31
Autor:
Zuzana Tothova, Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie Holmes, Catherine C. Landers, J. Erika Haydu, Edyta Malolepsza, Christina Hartigan, Melanie Donahue, Katerina D. Popova, Sebastian Koochaki, Sergey V. Venev, Jeanne Rivera, Edwin Chen, Kasper Lage, Monica Schenone, Alan D. D’Andrea, Steven A. Carr, Elizabeth A. Morgan, Job Dekker, Benjamin L. Ebert
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myelo
Externí odkaz:
https://doaj.org/article/04d99d4ec50c41c1a8bc57f790a16758
Publikováno v:
G3: Genes | Genomes | Genetics. Feb2022, Vol. 12 Issue 2, p1-7. 7p.
Publikováno v:
BioTechniques, Vol 62, Iss 4, Pp 165-174 (2017)
Cell lines expressing foreign genes have been widely used to produce a variety of recombinant proteins. However, generating recombinant protein–expressing cell lines is usually a lengthy process and the resulting protein expression levels are often
Externí odkaz:
https://doaj.org/article/e48423d5e1684dcebabeedde29da5874
Autor:
Vasileios Kargas, Pablo Castro-Hartmann, Norberto Escudero-Urquijo, Kyle Dent, Christine Hilcenko, Carolin Sailer, Gertrude Zisser, Maria J Marques-Carvalho, Simone Pellegrino, Leszek Wawiórka, Stefan MV Freund, Jane L Wagstaff, Antonina Andreeva, Alexandre Faille, Edwin Chen, Florian Stengel, Helmut Bergler, Alan John Warren
Publikováno v:
eLife, Vol 8 (2019)
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how integration o
Externí odkaz:
https://doaj.org/article/68e853793d0c4ab19d7cce1b81cf73da
Autor:
Ann Mullally, Fatima Al-Shahrour, Rebekka K. Schneider, Julie-Aurore Losman, Zuzana Tothova, Elizabeth A. Morgan, Ofir Wolach, Silvia Giannini, Natalie Florescu, Fabian Peisker, Amy Ko, Emily A. Rosen, Javier Perales-Patón, Edwin Chen, Nouran S. Abdelfattah, Shannon Elf
Supplementary Table S2. sgRNA sequences and Primer sequences used for CRISPR/Cas9 genome editing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6743c05e93cadcc4fee91eeb313e3637
https://doi.org/10.1158/2159-8290.22531491
https://doi.org/10.1158/2159-8290.22531491
Autor:
Ann Mullally, Fatima Al-Shahrour, Rebekka K. Schneider, Julie-Aurore Losman, Zuzana Tothova, Elizabeth A. Morgan, Ofir Wolach, Silvia Giannini, Natalie Florescu, Fabian Peisker, Amy Ko, Emily A. Rosen, Javier Perales-Patón, Edwin Chen, Nouran S. Abdelfattah, Shannon Elf
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225b3d2075451903b5fcff9e4c3c0a7f
https://doi.org/10.1158/2159-8290.22531497.v1
https://doi.org/10.1158/2159-8290.22531497.v1
Autor:
Ann Mullally, Fatima Al-Shahrour, Rebekka K. Schneider, Julie-Aurore Losman, Zuzana Tothova, Elizabeth A. Morgan, Ofir Wolach, Silvia Giannini, Natalie Florescu, Fabian Peisker, Amy Ko, Emily A. Rosen, Javier Perales-Patón, Edwin Chen, Nouran S. Abdelfattah, Shannon Elf
Supplementary Figure S5. Immunoblotting of Calr-immunoprecipitated proteins and whole cell lysates from Ba/F3-Cas9 and Ba/F3-MPL-Cas9 cells targeted with Calr-directed CRISPR gene editing using a control guide, Calr guide m1, or Calr guide m2 demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c11696894dc67ffc41e435b2f774eb4
https://doi.org/10.1158/2159-8290.22531500
https://doi.org/10.1158/2159-8290.22531500