Query-Guided Protein-Protein Interaction Inhibitor Discovery

Autor: Celis, S, Hobor, F, James, T, Bartlett, GJ, Ibarra, AA, Shoemark, DK, Hegedüs, Z, Hetherington, K, Woolfson, DN, Sessions, RB, Edwards, TA, Andrews, DM, Nelson, A, Wilson, AJ

Protein–protein interactions (PPIs) are central to biological mechanisms, and can serve as compelling targets for drug discovery. Yet, the discovery of small molecule inhibitors of PPIs remains challenging given the large and typically shallow topo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::11debccf988e715c53d9305e43a6f9c2
https://eprints.whiterose.ac.uk/171361/2/d1sc00023c.pdf

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle

Autor: Surtees, R, Dowall, SD, Shaw, A, Armstrong, S, Hewson, R, Carroll, MW, Mankouri, J, Edwards, TA, Hiscox, JA, Barr, JN

Publikováno v: JOURNAL OF VIROLOGY

The Nairovirus genus of the Bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. Of these serogroups, the Crimean-Congo hemorrhagic fever virus (CCHFV) serogroup comprises sole members CCH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f98fe336d55845a585b2ea0d2edbcfd8

Towards 'Bionic' Proteins: Replacement of Continuous Sequences from HIF-1α with Proteomimetics to Create Functional p300 Binding HIF-1α Mimics

Autor: Burslem, G, Kyle, H, Breeze, AL, Edwards, TA, Nelson, A, Warriner, SL, Wilson, AJ

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6f7587bd789774833ca97666fff6b9a6
https://eprints.whiterose.ac.uk/96585/13/c6cc01812b.pdf

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

Autor: Tanner, SJ, Ariza, A, Richard, CA, Kyle, HF, Dods, RL, Blondot, ML, Wu, W, Trincão, J, Trinh, CH, Hiscox, JA, Carroll, MW, Silman, NJ, Eléouët, JF, Edwards, TA, Barr, JN

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (4), pp.1580-1585. ⟨10.1073/pnas.1317262111⟩

International audience; The M2-1 protein of the important pathogen human respiratory syncytial virus is a zinc-binding transcription antiterminator that is essential for viral gene expression. We present the crystal structure of full-length M2-1 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0aaa88bf7896b4d794b58214639cf432
https://hal.inrae.fr/hal-02631183

The Indonesian Throughflow and its Impact on Biogeochemistry in the Indonesian Seas

Autor: Edwards Taufiqurrahman, A’an J. Wahyudi, Yukio Masumoto

Publikováno v: ASEAN Journal on Science and Technology for Development, Vol 37, Iss 1, Pp 29–35-29–35 (2020)

It has been widely known that the Indonesian Throughflow (ITF) is an important inter-ocean connection with unique and complex oceanographic and geographic conditions, as well as a strong relation to both regional and global ocean currents and climate

Externí odkaz: https://doaj.org/article/cf087f8ae008414ab91b479f15761225