Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction

Autor: Bornschein, J, Wernisch, L, Secrier, M, Miremadi, A, Perner, J, MacRae, S, O'Donovan, M, Newton, R, Menon, S, Bower, L, Eldridge, MD, Devonshire, G, Cheah, C, Turkington, R, Hardwick, RH, Selgrad, M, Venerito, M, Malfertheiner, P, Fitzgerald, RC, Noorani, A, Elliott, RF, Edwards, PAW, Grehan, N, Nutzinger, B, Crawte, J, Chettouh, H, Contino, G, Li, X, Gregson, E, Zeki, S, De la Rue, R, Malhotra, S, Tavare, S, Lynch, AG, Smith, ML, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Noble, F, Owsley, J, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Grabowska, A

Publikováno v: on behalf of the OCCAMS Consortium 2019, ' Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction ', International Journal of Cancer . https://doi.org/10.1002/ijc.32384
International Journal of Cancer

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247888413c0d73e27a41f5f76d2e9dd0
https://doi.org/10.1002/ijc.32384

Low-cost and clinically applicable copy number profiling using repeat DNA

Autor: S Jammula, A Lynch, Yeng Ang, Charles Crichton, Andrew D Beggs, T Hupp, van Lanschot Mcv., S Puig, F Ciccarelli, L Lovat, E. Fidziukiewicz, J Bornschein, N Carroll, M Lewis, J Owsley, S Abujudeh, R D la Rue, M Tripathi, A J Metz, H Barr, A Miremadi, Jason Crawte, Shaun R. Preston, S Oakes, C Peters, Simon Tavaré, Juliane Perner, O Tucker, B Kumar, C Harden, V Goh, G Devonshire, S Hayes, P Safranek, Laszlo Igali, Andy G. Lynch, J Zylstra, Barbara Nutzinger, Oesophageal Cancer Clinical, A Noorani, I Bagwan, J Gossage, A Davies, A. Northrop, Irshad Soomro, Jim Davies, X Li, Shalini Malhotra, Nicola Grehan, G Sanders, P Kaye, Lawrence Bower, P Taniere, V Save, Edwards Paw., Christopher C.W. Hughes, Rehan Haidry, S Parsons, E Cheong, A Hindmarsh, N Shepherd, Ula Mahadeva, Edward Morrissey, J Saunders, F Chang, M Eldridge, Maria O'Donovan, R O’Neill, S Lishman, S S Zeki, Michael F. Scott, G Hanna, T Underwood, Weaver Jmj., Rebecca C. Fitzgerald, M Pusung, S Sothi, Maria Secrier, S Suortamo, R Berrisford, Skipworth Rje., Shona MacRae, F Noble, R Fitzgerald, J Lagergren, A Grabowska, O Old, V Sujendran, R Turkington, Gianmarco Contino

Large-scale cancer genome studies suggest that tumors are driven by somatic copy number alterations (SCNAs) or single-nucleotide variants (SNVs). Due to the low-cost, the clinical use of genomics assays is biased towards targeted gene panels, which i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1841052f772eaaa01655d5864053eda
https://doi.org/10.1101/394429

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1

Autor: Garcia, E, Hayden, A, Birts, C, Britton, E, Cowie, A, Pickard, K, Mellone, M, Choh, C, Derouet, M, Duriez, P, Noble, F, White, MJ, Primrose, JN, Strefford, JC, Rose-Zerilli, M, Thomas, GJ, Ang, Y, Sharrocks, AD, Fitzgerald, RC, Underwood, TJ, MacRae, S, Grehan, N, Abdullahi, Z, De la Rue, R, Noorani, A, Elliott, RF, De Silva, N, Bornschein, J, O’Donovan, M, Contino, G, Yang, T-P, Chettouh, H, Crawte, J, Nutzinger, B, Edwards, PAW, Smith, L, Miremadi, A, Malhotra, S, Cluroe, A, Hardwick, R, Davies, J, Ford, H, Gilligan, D, Safranek, P, Hindmarsh, A, Sujendran, V, Carroll, N, Turkington, R, Hayes, SJ, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O’Neill, JR, Tucker, O, Taniere, P, Owsley, J, Crichton, C, Schusterreiter, C, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Welch, I, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Beardsmore, D, Anderson, C, Smith, ML, Secrier, M, Eldridge, MD, Bower, L, Achilleos, A, Lynch, AG, Tavare, S

New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a 55-year-old male with OAC wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::9ca52c74a9b86e3cbb9519ef47f7c8ae
http://hdl.handle.net/10044/1/42756

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

Autor: Chua, YL, Ito, Y, Pole, JCM, Newman, S, Chin, S-F, Stein, RC, Ellis, IO, Caldas, C, O'Hare, MJ, Murrell, A, Edwards, PAW

Neuregulin-1 (NRG1) is both a candidate oncogene and a candidate tumour suppressor gene. It not only encodes the heregulins and other mitogenic ligands for the ERBB family, but also causes apoptosis in NRG1-expressing cells. We found that most breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101635043cc2f8c399584a54da3e7b67
https://www.repository.cam.ac.uk/handle/1810/314686

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