Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Edward W. McBride"'
Publikováno v:
Molecular Pharmacology. 70:1406-1413
The GABA receptor (GABABR) is a class C G protein-coupled receptor (GPCR) that functions as an obligate heterodimer, composed of two heptahelical subunits, GABABR subunit 1 (R1) and GABABR subunit 2 (R2). In this study, we generated and pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac585a74f137558d6472bd6707653f9
https://doi.org/10.1124/mol.106.024463
https://doi.org/10.1124/mol.106.024463
Autor:
Duan Chen, Chun-Mei Zhao, Martin Beinborn, Alan S. Kopin, Ci Chen, Roger M. Freidinger, Edward W. McBride
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5525-5530
The search for small-molecule drugs that act at peptide hormone receptors has resulted in the identification of a wide variety of antagonists. In contrast, the discovery of nonpeptide agonists has been far more elusive. We have used a constitutively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f82f3abeed4ac9decaad5d44d475660
https://doi.org/10.1073/pnas.0831223100
https://doi.org/10.1073/pnas.0831223100
Autor:
Yong Ren, Michael Bläker, Lakshmi Seshadri, Edward W. McBride, Alan S. Kopin, Martin Beinborn
Publikováno v:
Journal of Molecular Neuroscience. 20:115-124
The Cholecystokinin type 1 and type 2 receptors (CCK-1R and CCK-2R) share >50% amino acid identity, as well as subnanomolar affinity for the endogenous peptide cholecystokinin octapeptide (CCK-8). Although it is likely that these two receptor subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca099a367d486f111f62cb1d84eeee5
https://doi.org/10.1385/jmn:20:2:115
https://doi.org/10.1385/jmn:20:2:115
Publikováno v:
Trends in Pharmacological Sciences. 21:346-353
Polymorphisms in G-protein-coupled receptors can alter drug affinity and/or activity. In addition, genetic differences in amino acid sequences can induce ligand-independent signaling, which in turn can lead to disease. With growing efforts in the fie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260a42b4ff4f76ada7111a2d322f84ba
https://doi.org/10.1016/s0165-6147(00)01526-1
https://doi.org/10.1016/s0165-6147(00)01526-1
Publikováno v:
Proceedings of the National Academy of Sciences. 94:11043-11048
The brain cholecystokinin-B/gastrin receptor (CCK-BR) is a major target for drug development because of its postulated role in modulating anxiety, memory, and the perception of pain. Drug discovery efforts have resulted in the identification of small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ccdc5015da8f2d9493bbabba7f9a54
https://doi.org/10.1073/pnas.94.20.11043
https://doi.org/10.1073/pnas.94.20.11043
Publikováno v:
Annals of the New York Academy of Sciences. 713:67-78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737355c810df7d9f6962c96d23a065e2
https://doi.org/10.1111/j.1749-6632.1994.tb44053.x
https://doi.org/10.1111/j.1749-6632.1994.tb44053.x
Publikováno v:
Journal of Biological Chemistry. 268:8164-8169
The predominant brain cholecystokinin receptor (CCK-B/gastrin) has been implicated in mediating many of the central effects of cholecystokinin, including anxiety, panic attacks, satiety, and analgesia, suggesting it is an important pharmacologic targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::787b80f61180c962ed8fa91f2a189afc
https://doi.org/10.1016/s0021-9258(18)53076-3
https://doi.org/10.1016/s0021-9258(18)53076-3
Autor:
Laurence J. Miller, Martin Beinborn, Young Mee Lee, Edward W. McBride, Herbert Y. Lin, Ming Lu, Lee F. Kolakowski, Alan S. Kopin
Publikováno v:
Proceedings of the National Academy of Sciences. 89:3605-3609
Gastrin is an important stimulant of acid secretion by gastric parietal cells and is structurally related to the peptide hormone cholecystokinin (CCK). The pharmacologic properties of the parietal cell gastrin receptor are very similar to the predomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89ea1644c1673f9180a841b52e14327
https://doi.org/10.1073/pnas.89.8.3605
https://doi.org/10.1073/pnas.89.8.3605
Publikováno v:
Regulatory peptides. 130(1-2)
Glucagon-like peptide-1 (GLP-1) and its cognate receptor play an important physiological role in maintaining blood glucose homeostasis. A GLP-1 receptor (GLP-1R) polymorphism in which threonine 149 is substituted with a methionine residue has been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e765ce2dfdecdf53024c4d754374ca9
https://pubmed.ncbi.nlm.nih.gov/15975668
https://pubmed.ncbi.nlm.nih.gov/15975668
Autor:
Isabelle Reveillaud, Yong Ren, Martin Beinborn, Edward W. McBride, Mark G. Hearn, Alan S. Kopin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(22)
Dopamine is an important neurotransmitter in the central nervous system of both Drosophila and mammals. Despite the evolutionary distance, functional parallels exist between the fly and mammalian dopaminergic systems, with both playing roles in modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a870480a39d8f0c084334a58c81c87
https://pubmed.ncbi.nlm.nih.gov/12391323
https://pubmed.ncbi.nlm.nih.gov/12391323