Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Edward W. Huber"'
Autor:
Norton P. Peet, John C. Huffman, Michael R. Whalon, Shyam Sunder, Robert J. Barbuch, Edward W. Huber
Publikováno v:
Journal of Heterocyclic Chemistry. 26:1611-1617
Treatment of 5-chloro-2-aminobenzophenone (1) with o-phenylenediamine, sodium acetate, and acetic acid gave 2-(acetyl)amino-5-chlorobenzophenone (5) rather than N-[(2-amino-5-chlorophenyl)phenylmethylene]-1,2-benzenediamine (3), as reported by Kulkar
Autor:
Farr Robert A, Edward W. Huber, Ramnik S. Shah, Richard A. Schnettler, Christian T. Goralski, Mark E. Webster, C. Richard Nevill, Bruce Baron, Timothy James-Norman Watson, Phillip L. Nyce, and Cynthia L. Rand, Boyd L. Harrison, Rajesh K. Mishra, Stephen W. Horgan, Franz J. Weiberth
Publikováno v:
Organic Process Research & Development. 4:477-487
MDL 103371 is a N-methyl-d-aspartate (NMDA)-type glycine receptor antagonist for the potential treatment of stroke. Evaluation of five different synthetic routes, which included Stille, Suzuki, enol ether, Knoevenagel, and the Mukaiyama coupling reac
Publikováno v:
Tetrahedron Letters. 38:3687-3690
The preparation and utility of conformationally constrained homoserines trans- 8 a and cis- 8b as intermediates for the synthesis of constrained glutamine mimetics trans- 1 a and cis- 1 b is presented.
Publikováno v:
Journal of Fluorine Chemistry. 82:47-50
Two difluorinated analogues of FPL 64176 (methyl 4-(2-benzylbenzoyl)-2,5-dimethylpyrrole-3-carboxylate) have been synthesized in three steps from 6-fluorophthalide and methyl 2,5-dimethylpyrrole-3-carboxylate. Significant overlap of signals was obser
Publikováno v:
Tetrahedron Letters. 37:4091-4094
The synthesis of diastereomeric substituted proline peptidomimetics as conformationally restricted tyrosine derivatives 1a,b has been accomplished utilizing the intramolecular hydroboration-cycloalkylation of azido-olefins 7a,b as the key step.
Publikováno v:
Tetrahedron. 52:45-58
(E)- and (Z)-Fluorovinyl sulfones (II) form (fluorovinyl)stannanes (III) on treatment with two equivalents of tributyltin hydride and a catalytic amount of AIBN; the free radical catalyzed reaction proceeds with retention of configuration for 2,2-dis
Publikováno v:
Analytical Chemistry. 68:2379-2385
A series of compounds were studied which had increasing alkyl chain length between an aromatic group and a tertiary amine. In this homologous series, a maximum in retention versus alkyl chain length was found for a wide range of mobile phases using e
Publikováno v:
The Journal of Organic Chemistry. 60:4947-4950
Publikováno v:
Journal of Heterocyclic Chemistry. 32:183-187
Several 1,2,4-triazole derivatives containing a 2-fluorophenyl substituent at either the 3- or 5-position and a methyl group at the 4-position were synthesized. These derivatives exhibit long-range 19F-1H and 19F-13C through-space coupling in their 1
Publikováno v:
Journal of Heterocyclic Chemistry. 32:33-41
The reactions of ninhydrin (1) with β-ketoesters and β-diketones were studied. Two kinds of products were observed, which were either simple adducts of the dicarbonyl compounds to the center carbonyl group of ninhydrin, or tricyclic indeno[1,2-b]fu