Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.

Autor: Amy M Smith, E Scott Graham, Sheryl Xia Feng, Robyn L Oldfield, Peter M Bergin, Edward W Mee, Richard L M Faull, Maurice A Curtis, Mike Dragunow

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80463 (2013)

The chemokine Interferon gamma-induced protein 10 (IP-10) and human leukocyte antigen (HLA) are widely used indicators of glial activation and neuroinflammation and are up-regulated in many brain disorders. These inflammatory mediators have been wide

Externí odkaz: https://doaj.org/article/6016b7af75b44d3d813a101fd060d30e

Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy

Autor: Amy M. Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show reg

Externí odkaz: https://doaj.org/article/c5eff623830540a29eefa250fa8e6004

Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage

Autor: Riku Kivisaari, Michel Bojanowski, Joseph Dedrick Jordan, Nima Etminan, Thomas P. Bleck, John Reavey-Cantwell, Gary Redekop, Rodney Allan, Nicholas Bambakidis, Guy Rosenthal, Hagen B. Huttner, Andreas Unterberg, Nerissa Ko, Adam Polifka, Lucas Elijovich, Joseph Zabramski, Eric Sauvageau, Wayne M. Clark, David Kung, Yu Mi Ryang, Menashe Zaaroor, Robert F. James, Ondrej Bradac, Juha Öhman, Gaurav Gupta, Sagi Harnof, George A. Lopez, Matthew F. Lawson, Benjamin R. Saville, Andrew P. Carlson, Robert L. Grubb, Moshe Hadani, Paul Vespa, David Ng, Jose I. Suarez, Khaled Aziz, Herbert J. Faleck, David Ledoux, Pascal Jabbour, Thomas Westermaier, Wai Sang Poon, Jürgen Meixensberger, Michael Kelly, R Loch Macdonald, Edward W. Mee, George K.C. Wong, Laith Altaweel, Kevin Hatton, Aman B. Patel, Vincent Ng Yew Poh, Jan Regelsberger, Sepideh Amin-Hanjani, Martin Smrčka, Michael Miller, Sherry Chou, Shouri Lahiri, Raimund Helbok, Cappi Lay, Erich Schmutzhard, Mark R. Harrigan, Howard M. Proskin, Raymond D Turner, Jirina Habalova, Ian Seppelt, Tim Darsaut, Stephan A. Mayer, Daniel E. Walzman, Peter Papadakos, Francois Aldrich, Wai Man Lui, David Langer, Michael N. Diringer, Ciaran J. Powers, Daniel Hänggi, T Hrbáč, Koji C. Ebersole, Jürgen Konczalla, William D. Freeman, Roland Goldbrunner, Peter Vajkoczy, Amal Abou-Hamden, Ajith J. Thomas, Julian Spears, Arun P. Amar, Babak S. Jahromi, Charles C. Matouk, John H. Wong, Oliver Müller, Carmelo Graffagnino

Publikováno v: Stroke. 51:1142-1149

Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf49a5472c5c025e24ad939b4dc305
https://doi.org/10.1161/strokeaha.119.027396

Identifying Neural Progenitor Cells in the Adult Human Brain

Autor: Thomas I H, Park, Henry J, Waldvogel, Johanna M, Montgomery, Edward W, Mee, Peter S, Bergin, Richard L M, Faull, Mike, Dragunow, Maurice A, Curtis

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2389

The discovery, in 1998, that the adult human brain contains at least two populations of progenitor cells and that progenitor cells are upregulated in response to a range of degenerative brain diseases has raised hopes for their use in replacing dying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e22901a4f34847fe5eeb3507ca401d06
https://pubmed.ncbi.nlm.nih.gov/34558008

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease

Autor: Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow

Publikováno v: Communications biology. 5(1)

Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78707940c98a299d8b9bf86c4461856f
https://pubmed.ncbi.nlm.nih.gov/35301433