Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Edward W Mee"'
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signa
Externí odkaz:
https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a
Autor:
Amy M. Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show reg
Externí odkaz:
https://doaj.org/article/c5eff623830540a29eefa250fa8e6004
Autor:
Leon C. D. Smyth, Justin Rustenhoven, Thomas I.-H. Park, Patrick Schweder, Deidre Jansson, Peter A. Heppner, Simon J. O’Carroll, Edward W. Mee, Richard L. M. Faull, Maurice Curtis, Mike Dragunow
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of inflammation-related studies in endothelia and pericytes h
Externí odkaz:
https://doaj.org/article/63936bf9cba943b9bb8265ccf406b16c
Autor:
Riku Kivisaari, Michel Bojanowski, Joseph Dedrick Jordan, Nima Etminan, Thomas P. Bleck, John Reavey-Cantwell, Gary Redekop, Rodney Allan, Nicholas Bambakidis, Guy Rosenthal, Hagen B. Huttner, Andreas Unterberg, Nerissa Ko, Adam Polifka, Lucas Elijovich, Joseph Zabramski, Eric Sauvageau, Wayne M. Clark, David Kung, Yu Mi Ryang, Menashe Zaaroor, Robert F. James, Ondrej Bradac, Juha Öhman, Gaurav Gupta, Sagi Harnof, George A. Lopez, Matthew F. Lawson, Benjamin R. Saville, Andrew P. Carlson, Robert L. Grubb, Moshe Hadani, Paul Vespa, David Ng, Jose I. Suarez, Khaled Aziz, Herbert J. Faleck, David Ledoux, Pascal Jabbour, Thomas Westermaier, Wai Sang Poon, Jürgen Meixensberger, Michael Kelly, R Loch Macdonald, Edward W. Mee, George K.C. Wong, Laith Altaweel, Kevin Hatton, Aman B. Patel, Vincent Ng Yew Poh, Jan Regelsberger, Sepideh Amin-Hanjani, Martin Smrčka, Michael Miller, Sherry Chou, Shouri Lahiri, Raimund Helbok, Cappi Lay, Erich Schmutzhard, Mark R. Harrigan, Howard M. Proskin, Raymond D Turner, Jirina Habalova, Ian Seppelt, Tim Darsaut, Stephan A. Mayer, Daniel E. Walzman, Peter Papadakos, Francois Aldrich, Wai Man Lui, David Langer, Michael N. Diringer, Ciaran J. Powers, Daniel Hänggi, T Hrbáč, Koji C. Ebersole, Jürgen Konczalla, William D. Freeman, Roland Goldbrunner, Peter Vajkoczy, Amal Abou-Hamden, Ajith J. Thomas, Julian Spears, Arun P. Amar, Babak S. Jahromi, Charles C. Matouk, John H. Wong, Oliver Müller, Carmelo Graffagnino
Publikováno v:
Stroke. 51:1142-1149
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf49a5472c5c025e24ad939b4dc305
https://doi.org/10.1161/strokeaha.119.027396
https://doi.org/10.1161/strokeaha.119.027396
Autor:
Hannah M. Gibbons, Amy M. Smith, H. Heng Teoh, Peter M. Bergin, Edward W. Mee, Richard L.M. Faull, Mike Dragunow
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 1, Pp 96-103 (2011)
Valproic acid (VPA) is widely used for the treatment of mood disorders and epilepsy, but its mechanism of action is unclear. In vivo and in vitro studies using rodent models have demonstrated that VPA has both neuroprotective and neurotrophic effects
Externí odkaz:
https://doaj.org/article/b33c786b26824114880a53538b0133ce
Autor:
Thomas I H, Park, Henry J, Waldvogel, Johanna M, Montgomery, Edward W, Mee, Peter S, Bergin, Richard L M, Faull, Mike, Dragunow, Maurice A, Curtis
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2389
The discovery, in 1998, that the adult human brain contains at least two populations of progenitor cells and that progenitor cells are upregulated in response to a range of degenerative brain diseases has raised hopes for their use in replacing dying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e22901a4f34847fe5eeb3507ca401d06
https://pubmed.ncbi.nlm.nih.gov/34558008
https://pubmed.ncbi.nlm.nih.gov/34558008
Autor:
Thomas I. H. Park, Henry J. Waldvogel, Johanna M. Montgomery, Edward W. Mee, Peter S. Bergin, Richard L. M. Faull, Mike Dragunow, Maurice A. Curtis
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617823
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8eb0b9c88dfe030966030dc1ab9c62
https://doi.org/10.1007/978-1-0716-1783-0_12
https://doi.org/10.1007/978-1-0716-1783-0_12
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications biology. 5(1)
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78707940c98a299d8b9bf86c4461856f
https://pubmed.ncbi.nlm.nih.gov/35301433
https://pubmed.ncbi.nlm.nih.gov/35301433
Autor:
Patrick Schweder, Mike Dragunow, Peter J. Choi, William A. Denny, Thomas I. H. Park, Elizabeth Cooper, Edward W. Mee, Richard L.M. Faull, Jiney Jose
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2617-2621
We describe the synthesis of drug-dye conjugate 1 between anaplastic lymphoma kinase inhibitor Crizotinib and heptamethine cyanine dye IR-786. The drug-dye conjugate 1 was evaluated in three different patient-derived glioblastoma cell lines and showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870cc59dba3e84819e53e21240ae31e1
https://doi.org/10.1016/j.bmcl.2019.07.051
https://doi.org/10.1016/j.bmcl.2019.07.051
Autor:
Clinton Turner, Peter J. Choi, Thomas I. H. Park, Jiney Jose, Richard L.M. Faull, William A. Denny, Edward W. Mee, Patrick Schweder, Elizabeth Cooper, Mike Dragunow
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Cytoprotective agents are mainly used to protect the gastrointestinal tract linings and in the treatment of gastric ulcers. These agents are devoid of appreciable cytotoxic or cytostatic effects, and medicinal chemistry efforts to modify them into an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7d1954e3fb475af9112776a26c57f
https://pubmed.ncbi.nlm.nih.gov/34438012
https://pubmed.ncbi.nlm.nih.gov/34438012