Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Edward W Harhaj"'
Autor:
Suchitra Mohanty, Sujit Suklabaidya, Alfonso Lavorgna, Takaharu Ueno, Jun-ichi Fujisawa, Nyater Ngouth, Steven Jacobson, Edward W. Harhaj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Human T-cell leukemia virus type 1 (HTLV-1) infection is linked to the development of adult T-cell leukemia/lymphoma (ATLL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Ta
Externí odkaz:
https://doaj.org/article/a04449588b6a4f07960705a393a0b93e
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53717 (2013)
A key feature of the innate antiviral immune response is a rapid nonspecific response to virus infection largely mediated by the induction and extracellular secretion of type I interferons (IFNs) that restrict virus replication. Cytoplasmic sensors s
Externí odkaz:
https://doaj.org/article/5fa91f2d337f4590a3bb328c1ed6b73e
Autor:
Suchitra Mohanty, Edward W. Harhaj
Publikováno v:
Pathogens, Vol 12, Iss 5, p 735 (2023)
Human T lymphotropic virus-1 (HTLV-1) was the first identified oncoretrovirus, which infects and establishes a persistent infection in approximately 10–20 million people worldwide. Although only ~5% of infected individuals develop pathologies such
Externí odkaz:
https://doaj.org/article/39cd4ae4b0084c2a9d81ed0563228a89
Autor:
Kiran K. Madugula, Julie Joseph, Catherine DeMarino, Rashida Ginwala, Vanessa Teixeira, Zafar K. Khan, Dominic Sales, Sydney Wilson, Fatah Kashanchi, Amanda W. Rushing, Isabelle Lemasson, Edward W. Harhaj, Murali Janakiram, B. Hilda Ye, Pooja Jain
Publikováno v:
Haematologica, Vol 107, Iss 12 (2022)
Adult T-cell leukemia and lymphoma (ATLL) is an intractable T-cell neoplasia caused by a retrovirus, namely human T-cell leukemia virus type 1 (HTLV-1). Patients suffering from ATLL present a poor prognosis and have a dearth of treatment options. In
Externí odkaz:
https://doaj.org/article/a0e484c8851347b0903ce1d12f0f35ba
Publikováno v:
Autophagy
TAX1BP1 is a selective macroautophagy/autophagy receptor that plays a central role in host defense to pathogens and in regulating the innate immune system. TAX1BP1 facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5c07088d60a2e4aae89b6e0908658c
https://pubmed.ncbi.nlm.nih.gov/35470757
https://pubmed.ncbi.nlm.nih.gov/35470757
Autor:
Suchitra Mohanty, Edward W. Harhaj
Publikováno v:
Pathogens, Vol 9, Iss 7, p 543 (2020)
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a neoplasm of CD4+CD25+ T cells that occurs in 2–5% of infected individuals after decades of asymptomatic latent infection. Multi
Externí odkaz:
https://doaj.org/article/05a7caab45764c36b5b20b038028bcd9
Autor:
Kiran Madugula, Dip Patel, Edward W. Harhaj, Pooja Jain, Ria Mulherkar, DeGaulle I. Chigbu, Zafar K. Khan
Publikováno v:
Oncotarget
Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d671823a5efd37b91019833ee6cdc4
http://europepmc.org/articles/PMC6505634
http://europepmc.org/articles/PMC6505634
Autor:
Kiran K. Madugula, Julie Joseph, Catherine DeMarino, Rashida Ginwala, Vanessa Teixeira, Zafar K. Khan, Dominic Sales, Sydney Wilson, Fatah Kashanchi, Amanda W. Rushing, Isabelle Lemasson, Edward W. Harhaj, Murali Janakiram, B. Hilda Ye, Pooja Jain
Publikováno v:
Haematologica. 107(12)
Adult T-cell leukemia and lymphoma (ATLL) is an intractable T-cell neoplasia caused by a retrovirus, namely human T-cell leukemia virus type 1 (HTLV-1). Patients suffering from ATLL present a poor prognosis and have a dearth of treatment options. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295a832c80345c7bd672831ecaf205a3
https://pubmed.ncbi.nlm.nih.gov/35615924
https://pubmed.ncbi.nlm.nih.gov/35615924
Autor:
B. Hilda Ye, Catherine DeMarino, Julie Joseph, Dominc Sales, Murali Janakiram, Isabelle Lemasson, Sydney Wilson, Pooja Jain, Zafar K. Khan, Edward W. Harhaj, Amanda W. Rushing, Fatah Kashanchi, Vanessa Teixeira, Rashida Ginwala, Kiran Madugula
Background. HTLV-1 is a complex human retrovirus and an etiologic agent causing a malignant and intractable T-cell neoplasia termed Adult T-cell leukemia and lymphoma (ATLL). Patients suffering from ATLL present with poor prognoses and a dearth of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb38d27d38b446c297f5625cf6577fb
https://doi.org/10.21203/rs.3.rs-362537/v1
https://doi.org/10.21203/rs.3.rs-362537/v1
TAX1BP1 is a selective autophagy receptor which inhibits NF-κB and RIG-I-like receptor (RLR) signaling to prevent excessive inflammation and maintain homeostasis. Selective autophagy receptors such as p62/SQSTM1 and OPTN are phosphorylated by the no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccfe3fd33f6d81c612407f9f927d5f2b
https://doi.org/10.1101/2021.01.07.425702
https://doi.org/10.1101/2021.01.07.425702