Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Edward W, Tate"'
Autor:
Goran Tomić, Clare Sheridan, Alice Y. Refermat, Marc P. Baggelaar, James Sipthorp, Bhuvana Sudarshan, Cory A. Ocasio, Alejandro Suárez-Bonnet, Simon L. Priestnall, Eleanor Herbert, Edward W. Tate, Julian Downward
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114224- (2024)
Summary: Metastasis is one of the defining features of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor prognosis. In this study, the palmitoyl transferase ZDHHC20 was identified in an in vivo short hairpin RNA (shRNA) screen as criti
Externí odkaz:
https://doaj.org/article/76f4fd25faf047aa857156b8f167bc94
Autor:
Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H. Lassen, Sam J. Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A. Fernandes, Tao Dong, Edward W. Tate, Elena Di Daniel, Benedikt M. Kessler
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114152- (2024)
Summary: Activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome complex is an essential innate immune signaling mechanism. To reveal how human NLRP3 inflammasome assembly and activation are controlled, in particular b
Externí odkaz:
https://doaj.org/article/a5167cfa972c4f8d8edd1f27601d7520
Autor:
Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As well as how the membrane environment influences the role of CD59 in complement reg
Externí odkaz:
https://doaj.org/article/1d86c42b34e04084a69e7434c448c724
Autor:
Sabrina Yahiya, Charlie N. Saunders, Sarah Hassan, Ursula Straschil, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J. Delves, Edward W. Tate, Anna Barnard, Matthew J. Fuchter, Jake Baum
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/537be52acb9d42a7a54013ab74d8c046
Autor:
Lalita Priyamvada, Wouter W Kallemeijn, Monica Faronato, Kimberly Wilkins, Cynthia S Goldsmith, Catherine A Cotter, Suany Ojeda, Roberto Solari, Bernard Moss, Edward W Tate, Panayampalli Subbian Satheshkumar
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010662 (2022)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment w
Externí odkaz:
https://doaj.org/article/1b85968db8404d64b270c818449b4213
Publikováno v:
Toxins, Vol 15, Iss 7, p 430 (2023)
CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells. While CD59 bl
Externí odkaz:
https://doaj.org/article/13649c1349d443119008cb6bad20ff67
Autor:
Thomas R. Jackson, Aini Vuorinen, Laia Josa-Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V.L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony, Deanne Gracias, Lorna McCall, Robert Westwood, Georg C. Terstappen, Stephen G. Davies, Edward W. Tate, Graham M. Wynne, Paresh Vyas, Angela J. Russell, Thomas A. Milne
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104787- (2022)
Summary: Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple
Externí odkaz:
https://doaj.org/article/41383f2f5a8d4ffeb2940ad8bb573d15
Publikováno v:
ACS Central Science, Vol 6, Iss 8, Pp 1281-1284 (2020)
Externí odkaz:
https://doaj.org/article/7acb2615e03d4de4bf45430917e289c4
Autor:
Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity
Externí odkaz:
https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
Autor:
Cyril Dian, Inmaculada Pérez-Dorado, Frédéric Rivière, Thomas Asensio, Pierre Legrand, Markus Ritzefeld, Mengjie Shen, Ernesto Cota, Thierry Meinnel, Edward W. Tate, Carmela Giglione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
N-terminal glycine myristoyl transferases (NMTs) catalyse the myristoylation of eukaryotic proteins. Here, the authors provide insights into the catalytic mechanism of NMTs by determining the crystal structures of human NMT1 in complex with reactive
Externí odkaz:
https://doaj.org/article/1d7d6b525886413db95bc8b3e99c1d00