Predicting mortality in febrile adults: comparative performance of the MEWS, qSOFA, and UVA scores using prospectively collected data among patients in four health-care sites in sub-Saharan Africa and South-Eastern AsiaResearch in context

Autor: Sham Lal, Manophab Luangraj, Suzanne H. Keddie, Elizabeth A. Ashley, Oliver Baerenbold, Quique Bassat, John Bradley, John A. Crump, Nicholas A. Feasey, Edward W. Green, Kevin C. Kain, Ioana D. Olaru, David G. Lalloo, Chrissy h. Roberts, David C.W. Mabey, Christopher C. Moore, Heidi Hopkins, Sara Ajanovic, Benjamin Amos, Stéphanie Baghoumina, Núria Balanza, Tsitsi Bandason, Tapan Bhattacharyya, Stuart D. Blacksell, Zumilda Boca, Christian Bottomley, Justina M. Bramugy, Clare IR. Chandler, Vilada Chansamouth, Mabvuto Chimenya, Joseph Chipanga, Anelsio Cossa, Ethel Dauya, Catherine Davis, Xavier de Lamballerie, Justin Dixon, Somyoth Douangphachanh, Audrey Dubot-Pérès, Michelle M. Durkin, Rashida A. Ferrand, Colin Fink, Elizabeth JA. Fitchett, Alessandro Gerada, Stephen R. Graves, Edward Green, Becca L. Handley, Coll D. Hutchison, Risara Jaksuwan, Jessica Jervis, Jayne Jones, Khamxeng Khounpaseuth, Katharina Kranzer, Khamfong Kunlaya, Pankaj Lal, Yoel Lubell, David CW. Mabey, Eleanor MacPherson, Forget Makoga, Sengchanh Manichan, Tegwen Marlais, Florian Maurer, Mayfong Mayxay, Michael Miles, Polycarp Mogeni, Campos Mucasse, Paul N. Newton, Chelsea Nguyen, Vilayouth Phimolsarnnousith, Mathieu Picardeau, Chrissy H. Roberts, Amphone Sengduangphachanh, Siho Sengsavang, Molly Sibanda, Somvai Singha, John Stenos, Ampai Tanganuchitcharnchai, Hira Tanvir, James E. Ussher, Marta Valente, Marie A. Voice, Manivanh Vongsouvath, Msopole Wamaka, L Joseph Wheat, Shunmay Yeung

Publikováno v: EClinicalMedicine, Vol 77, Iss , Pp 102856- (2024)

Summary: Background: Clinical severity scores can identify patients at risk of severe disease and death, and improve patient management. The modified early warning score (MEWS), the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA),

Externí odkaz: https://doaj.org/article/472ab60c07af4c819f058bc83c88007e

The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach).

Autor: Zhang Lin, Edward W Green, Simon G Webster, Michael H Hastings, David C Wilcockson, Charalambos P Kyriacou

Publikováno v: PLoS Genetics, Vol 19, Iss 10, p e1011011 (2023)

Circadian clocks in terrestrial animals are encoded by molecular feedback loops involving the negative regulators PERIOD, TIMELESS or CRYPTOCHROME2 and positive transcription factors CLOCK and BMAL1/CYCLE. The molecular basis of circatidal (~12.4 hou

Externí odkaz: https://doaj.org/article/f377a0ebbe284fd88ef6b4ec346cbefc

A non-linear optimisation method to extract summary statistics from Kaplan-Meier survival plots using the published P value

Autor: Andrew F. Irvine, Sara Waise, Edward W. Green, Beth Stuart

Publikováno v: BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-17 (2020)

Abstract Background Meta-analyses of studies evaluating survival (time-to-event) outcomes are a powerful technique to assess the strength of evidence for a given disease or treatment. However, these studies rely on the adequate reporting of summary s

Externí odkaz: https://doaj.org/article/74a0072899af41c7bc136736c96f46fd

Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE): protocol for a multisite prospective observational study of the causes of fever in Africa and Asia

Autor: David Mabey, Quique Bassat, David G Lalloo, David Bell, Stephen R Graves, Katharina Kranzer, John Bradley, Christopher M Parry, Mayfong Mayxay, Yoel Lubell, Paul N Newton, Heidi Hopkins, Chrissy H Roberts, Rashida A Ferrand, Felicity C Fitzgerald, Jayne Jones, Clare IR Chandler, John A Crump, Nicholas A Feasey, Benjamin Amos, Stuart D Blacksell, Vilada Chansamouth, Mabvuto Chimenya, Scott B Craig, David AB Dance, Ethel Dauya, Xavier de Lamballerie, Edward W Green, Kate A Haigh, Becca L Handley, Martin L Hibberd, Coll D Hutchison, Kevin C Kain, Pankaj Lal, Eleanor MacPherson, Tegwen Marlais, Florian P Maurer, Ioana D Olaru, John Stenos, Nelson Tembe, James E Ussher, Marta Valente, Pio Vitorino, Marie A Voice, L Joseph Wheat, Audrey Dubot-Pérès, Michelle M Durkin, Colin Fink

Publikováno v: BMJ Open, Vol 10, Iss 7 (2020)

Introduction Fever commonly leads to healthcare seeking and hospital admission in sub-Saharan Africa and Asia. There is only limited guidance for clinicians managing non-malarial fevers, which often results in inappropriate treatment for patients. Fu

Externí odkaz: https://doaj.org/article/80e60ae40c8243759d9c641c42ca03d0

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Autor: Rebecca Aron, Pasquale Pellegrini, Edward W. Green, Daniel C. Maddison, Kwadwo Opoku-Nsiah, Anna Osorio Oliveira, Jinny S. Wong, Aaron C. Daub, Flaviano Giorgini, Paul Muchowski, Steven Finkbeiner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal aut

Externí odkaz: https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e