Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Edward V, Prochownik"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel their own growth and license tumor immune evasion. However, the relationships between these functions remain poorly understood. Here, we report CRISPR s
Externí odkaz:
https://doaj.org/article/398b801bce3444af957970672364bf04
Autor:
Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V. Prochownik
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract The “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max‐like factor Mlx as
Externí odkaz:
https://doaj.org/article/21d46c4a8a1c4ee19059c58c19da19c0
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 5, Pp 1122-1127 (2023)
Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintena
Externí odkaz:
https://doaj.org/article/aa8930e9170b474d89666830e6a450e5
Autor:
Jianhong Zhao, Xiaojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi Wu, Mengjiao Li, Edward V. Prochownik, Ali Tavassoli, Congqing Jiang, Youjun Li
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes encoding enzymes for peroxisomal f
Externí odkaz:
https://doaj.org/article/e6dcfc904fcf4acebbe5587ed3ec5f0d
Autor:
Edward V. Prochownik, Huabo Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Despite MYC being among the most intensively studied oncogenes, its role in normal development has not been determined as Myc−/− mice do not survival beyond mid-gestation. Myc ± mice live longer than their wild-type counterparts and are slower t
Externí odkaz:
https://doaj.org/article/1f876640a07c4fde9b537814a91d1a5d
Autor:
Huabo Wang, Jie Lu, Taylor Stevens, Alexander Roberts, Jordan Mandel, Raghunandan Avula, Bingwei Ma, Yijen Wu, Jinglin Wang, Clinton Van’t Land, Toren Finkel, Jerry E. Vockley, Merlin Airik, Rannar Airik, Radhika Muzumdar, Zhenwei Gong, Michel S. Torbenson, Edward V. Prochownik
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112830- (2023)
Summary: MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in ways that support tumor induction and maintenance. Although Myc+/− mice are healthier and longer-lived than control mice, the long-term ramifications o
Externí odkaz:
https://doaj.org/article/592f094c57b94e779a6b09c1d1c41fbf
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequen
Externí odkaz:
https://doaj.org/article/39409f48c0d64b369a52a72edc3b1a84
Autor:
Zhiqiang Chen, Xinyi Zhou, Xiaojun Zhou, Yi Tang, Mingzhu Lu, Jianhong Zhao, Chenhui Tian, Mingzhi Wu, Yanliang Liu, Edward V. Prochownik, Fubing Wang, Youjun Li
Publikováno v:
Advanced Science, Vol 10, Iss 12, Pp n/a-n/a (2023)
Abstract β‐catenin signaling is abnormally activated in cancer. Here, this work screens the mevalonate metabolic pathway enzyme PMVK to stabilize β‐catenin signaling using a human genome‐wide library. On the one hand, PMVK‐produced MVA‐5P
Externí odkaz:
https://doaj.org/article/0597d71d8ea24677a6a0c5db2e8da9dd
Autor:
Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert N. Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew W. Duncan, Edward V. Prochownik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1785-1804 (2022)
Background & Aims: The c-Myc (Myc) Basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factor is deregulated in most cancers. In association with Max, Myc controls target genes that supervise metabolism, ribosome biogenesis, translation, a
Externí odkaz:
https://doaj.org/article/f512386ec4624aa09ce95376ee392615
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12618 (2023)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths globally. Incidence rates are steadily increasing, creating an unmet need for new therapeutic options. Recently, the inhibition of sirtuin-2 (Sirt2) was proposed as a potent
Externí odkaz:
https://doaj.org/article/65f2e99912a749cebdd3db1463ffdf49