Výsledky vyhledávání - "Edward T. Parkin"

Akademický článek

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

Autor: Edward T Parkin, Jessica E Hammond, Lauren Owens, Matthew D Hodges

Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0255715 (2022)

The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and

Externí odkaz: https://doaj.org/article/a745a6ae82f842bdb79098b253bbc06c

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Supplementary Methods from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

Autor: Edward T. Parkin, Noel W. Clarke, Michael D. Brown, Claire A. Hart, Claire L. Tinker, Catherine A. Parr-Sturgess

PDF file - 42K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ecee625477b19a6bb366fdd034f6f4
https://doi.org/10.1158/1541-7786.22517581.v1

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Data from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

Autor: Edward T. Parkin, Noel W. Clarke, Michael D. Brown, Claire A. Hart, Claire L. Tinker, Catherine A. Parr-Sturgess

A disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) are zinc metalloproteinases (ZMPs) that catalyze the “ectodomain shedding” of a range of cell surface proteins including signaling and adhesion molecules. These “

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6282dd72463ca2e063a887e07a49d86a
https://doi.org/10.1158/1541-7786.c.6541774

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Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

Autor: Edward T. Parkin, Noel W. Clarke, Michael D. Brown, Claire A. Hart, Claire L. Tinker, Catherine A. Parr-Sturgess

PDF file - 87K, The Jagged1 ectodomain generated in the presence of copper is smaller than constitutively-generated sJag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd28d6e1c20d8e1eae69fe08aa5bfd12
https://doi.org/10.1158/1541-7786.22517584

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Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

Autor: Edward T. Parkin, Noel W. Clarke, Michael D. Brown, Claire A. Hart, Claire L. Tinker, Catherine A. Parr-Sturgess

PDF file - 43K, Summary of catalytically active human ADAM family members tested as candidates for copper-enhanced shedding activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33273ce227b6c47973375e1c8311cd0d
https://doi.org/10.1158/1541-7786.22517578.v1

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Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

Autor: Edward T. Parkin, Noel W. Clarke, Michael D. Brown, Claire A. Hart, Claire L. Tinker, Catherine A. Parr-Sturgess

PDF file - 101K, Copper-mediated Jagged1 shedding is accompanied by reciprocal decreases in cell-associated holoprotein only at higher, physiologically irrelevant, metal concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3563f59fca85c54d0bc303c3e96fbc8e
https://doi.org/10.1158/1541-7786.22517590

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The Amyloid Precursor Protein Plays Differential Roles in the UVA Resistance and Proliferation of Human Retinal Pigment Epithelial Cells

Autor: Edward T. Parkin, Fatima Sultan

Publikováno v: Protein & Peptide Letters. 29:313-327

Background: Age-related macular degeneration (AMD) can be characterised by degeneration of retinal pigment epithelial (RPE) cells and the accumulation, in retinal drusen deposits, of amyloid beta-peptides proteolytically derived, by secretases, from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5bfd3c7a5b59d9af1cca220bfac74d
https://doi.org/10.2174/0929866529666220217124152

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Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

Autor: Neil Dawson, Alexandre Benedetto, Edward T. Parkin, Lauren V. Owens, Christopher J. Gaffney

Alzheimer's disease (AD) is the leading form of dementia but lacks curative treatments. Current understanding of AD aetiology attributes the development of the disease to the misfolding of two proteins; amyloid-β (Aβ) and hyperphosphorylated tau, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a675cef535b480231bd84806b2120c9
https://doi.org/10.1016/j.brainres.2020.147264

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Osteonectin as a screening marker for pancreatic cancer: A prospective study

Autor: Edward T. Parkin, Dimitris Raptis, Sanjay Panchal, Athanasios G. Papavassiliou, George Sgourakis, Angeliki Papapanagiotou, P. Brotzakis, K. Karkoulias

Publikováno v: The Journal of International Medical Research
Journal of International Medical Research, Vol 46 (2018)

Objective Osteonectin plays a central role in various processes during the development of pancreatic adenocarcinoma. This prospective pilot study was performed to determine the feasibility of serum osteonectin as a screening tool for pancreatic cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1338c5017abbbf8c436789b8bddf6b6e
http://europepmc.org/articles/PMC6124255

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The E1 Copper Binding Domain of Full-Length Amyloid Precursor Protein Promotes Epithelial to Mesenchymal Transition in DU145 Cells in an Isoform-Specific Manner

Autor: Craig Delury, Edward T. Parkin, Mallory Gough

Publikováno v: International Journal of Biochemistry Research & Review. 6:1-10

Epithelial to mesenchymal transition (EMT) confers migratory and dynamic properties on cells and, as such, plays a pivotal role in the development of metastatic, castration resistant prostate cancer. The amyloid precursor protein (APP), although most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9032ef5f8a479f930db83de294095c7
https://doi.org/10.9734/ijbcrr/2015/14873

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