Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Edward T W Bampton"'
Autor:
Shankar Varadarajan, Kayoko Tanaka, Joshua L Smalley, Edward T W Bampton, Maurizio Pellecchia, David Dinsdale, Gary B Willars, Gerald M Cohen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56603 (2013)
Recently we described a new, evolutionarily conserved cellular stress response characterized by a reversible reorganization of endoplasmic reticulum (ER) membranes that is distinct from canonical ER stress and the unfolded protein response (UPR). Apo
Externí odkaz:
https://doaj.org/article/f2f1af8d7f7742d48a94c649482d40f4
The adult mammalian central nervous system (CNS) does not repair after injury. However, we and others have shown in earlier work that the neonatal CNS is capable of repair and importantly of allowing regenerating axons to re-navigate through the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dca729e78eec49a3be721ecff84c07
https://doi.org/10.1111/j.1469-7580.2004.00262.x
https://doi.org/10.1111/j.1469-7580.2004.00262.x
We have used PC12 cells to examine the effects of factors secreted by Schwann cells that promote cell survival and neurite outgrowth, and hence are likely candidates for promoting neuronal regeneration. RT-PCR showed that primary Schwann cells produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bef889520c01c13a6e4629dba3b4f13
https://ora.ox.ac.uk/objects/uuid:c2ce6afe-40b2-4470-8c48-bd98db175a2c
https://ora.ox.ac.uk/objects/uuid:c2ce6afe-40b2-4470-8c48-bd98db175a2c
Autor:
Jun Wei, Kayoko Tanaka, John S. Mitcheson, Gerald M. Cohen, Maurizio Pellecchia, Michael Butterworth, Edward T. W. Bampton, Shankar Varadarajan, David Dinsdale, Rachel E. Caves, Timothy W. Gant, Joshua L. Smalley
Publikováno v:
Cell Death & Differentiation. 19:1896-1907
Canonical endoplasmic reticulum (ER) stress, which occurs in many physiological and disease processes, results in activation of the unfolded protein response (UPR). We now describe a new, evolutionarily conserved cellular stress response characterise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d2b11ec30a2393af2cee0ec202a06b
https://doi.org/10.1038/cdd.2012.108
https://doi.org/10.1038/cdd.2012.108
Autor:
David Dinsdale, Gerald M. Cohen, Hassan A. Hamali, Roger T. Snowden, Edward T. W. Bampton, Meike Vogler, Xiao-Ming Sun, Alison H. Goodall, Martin J. S. Dyer
Publikováno v:
Blood. 117:7145-7154
Apoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen after platelet activation is poorly understood. ABT-263 (Navitoclax), a specific inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff03be15c8a5bbd16cafb84dc057ed67
https://doi.org/10.1182/blood-2011-03-344812
https://doi.org/10.1182/blood-2011-03-344812
Publikováno v:
Autophagy. 6:1042-1056
It is becoming increasingly clear that there is crosstalk between the apoptotic and autophagic pathways, with autophagy helping to contribute to cell death by providing energy to allow the energy-requiring programmed cell death process to complete, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc7a49668483c072b5393e01f0bdded
https://doi.org/10.4161/auto.6.8.13337
https://doi.org/10.4161/auto.6.8.13337
Autor:
Mario Rossi, Giambattista Bonanno, Maria Azucena Guerra-Martin, Marco Milanese, Eliana Munarriz, Pierluigi Nicotera, Gerry Melino, Stefano Bartesaghi, Richard A. Knight, Edward T. W. Bampton, Paul Glynn, David Dinsdale
Publikováno v:
Journal of Cell Science. 122:3330-3339
Alterations in the autophagic pathway are associated with the onset and progression of various diseases. However, despite the therapeutic potential for pharmacological modulators of autophagic flux, few such compounds have been characterised. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d92d672ba8376a74b4ca8d83891465
https://doi.org/10.1242/jcs.048181
https://doi.org/10.1242/jcs.048181
Publikováno v:
Cell Calcium. 43:296-306
High-resolution fluorescent imaging of mitochondrial-targeted probes was used to examine the ability of mitochondria to decode complex spatial and temporal Ca 2+ signals evoked in synaptically active networks of hippocampal neurons. Green-to-red phot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a5ecb4003c31dfd552fe739f8973f8
https://doi.org/10.1016/j.ceca.2007.06.007
https://doi.org/10.1016/j.ceca.2007.06.007
Publikováno v:
Molecular and Cellular Neuroscience. 37:298-311
Poorly-controlled hyperglycaemia reduces peripheral nerve regeneration in diabetes through ill-understood mechanisms. Apoptosis is one proposed primary response. We examined how hyperglycaemia affects regeneration of axons and Schwann cells (SC) from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416518b3bf78f2b07393d964f448340a
https://doi.org/10.1016/j.mcn.2007.10.004
https://doi.org/10.1016/j.mcn.2007.10.004
Publikováno v:
European Journal of Neuroscience. 21:2611-2623
We have investigated the factors made by Schwann cells (SCs) that stimulate survival and neurite outgrowth from postnatal rat retinal ganglion cells (RGCs). These effects are preserved under K252a blockade of the Trk family of neurotrophin receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ee484f9a43438a5cb30d12f9000ca0
https://doi.org/10.1111/j.1460-9568.2005.04128.x
https://doi.org/10.1111/j.1460-9568.2005.04128.x