Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Edward S. Reynolds"'
Publikováno v:
Environmental Health Perspectives
The fundamental reactivity or stability of the chloroethylene molecules affects their hepatotoxic potential. Extent and symmetry of the chlorine substitution, which alters electron delocalization, charge polarization, and solubility, affect biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae62ed8845f9c1d69c686c4a15adff1
https://doi.org/10.1289/ehp.7721137
https://doi.org/10.1289/ehp.7721137
Publikováno v:
Gastroenterology. 73:1072-1076
Cysteamine and propionitrile induce the formation of duodenal ulcers in rats in 24 to 72 hr. In this study we investigated the effect of these compounds on gastric emptying by measuring the disappearance of intragastrically administered [57Co]vitamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac0a728cd354312396a2eb3659cc9eb
https://doi.org/10.1016/s0016-5085(19)31860-8
https://doi.org/10.1016/s0016-5085(19)31860-8
Publikováno v:
Journal of Chromatography A. 241:419-422
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c074c8ebf41074ce1f200f86a683f54
https://doi.org/10.1016/s0021-9673(00)81771-9
https://doi.org/10.1016/s0021-9673(00)81771-9
Publikováno v:
Toxicology and Applied Pharmacology. 29:377-388
Insight into the mechanism of the toxic interaction of CCl 4 with liver endoplasmic reticulum was sought through modulation of the early in vivo effects of CCl 4 by agents which either inhibit its binding with cytochrome P-450 or have free radical se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4eafa9dcfc6b87fbbd01f99b49ee5de
https://doi.org/10.1016/0041-008x(74)90110-0
https://doi.org/10.1016/0041-008x(74)90110-0
Autor:
Edward S. Reynolds, Poh-Gek Forkert
Publikováno v:
Experimental Lung Research. 3:57-68
Oral administration of 1,1-dichloroethylene (1,1-DCE) produces acute injury to the lungs of C57Bl/6 mice. The bronchiolar epithelium is most severely affected with damage selective for Clara cells. After a 100 mg kg/dose of 1.1-DCE. Clara cells show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9944b87ab6df2d89069d2885c61be86
https://doi.org/10.3109/01902148209115816
https://doi.org/10.3109/01902148209115816
Publikováno v:
Digestive Diseases and Sciences. 24:471-477
Insight into the pathogenesis and etiology of experimental duodenal ulceration was sought by studying the modulation of this disease in rats by selective vagotomy, chemical sympathectomy, histamine depletion, histamine H-2 receptor antagonists (eg, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00f8eb94e0c09cadc6db0af4b947ad3
https://doi.org/10.1007/bf01299831
https://doi.org/10.1007/bf01299831
Publikováno v:
Biochemical Pharmacology. 24:2075-2081
Neither single nor multiple halothane anesthesia at 2-day or 2-week intervals (0.85% for 5 hr) altered the metabolism by the rat in vivo of halothane ( 14 CF 3 CHBrCl), as determined by the recovery of radioactivity in cold xylene and 14 CO 2 from ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500045503c5e9673eeb8f100f6fad5af
https://doi.org/10.1016/0006-2952(75)90105-7
https://doi.org/10.1016/0006-2952(75)90105-7
Publikováno v:
Biochemical Pharmacology. 33:3363-3374
Fasted male rats were given six doses of 14CCl4 ranging from non-hepatotoxic (0.1 mmole/kg) to severely hepatotoxic (26 mmoles/kg). Time-course and pharmacokinetics of CCl4, 14CO2 and CHCl3 elimination by exhalation were monitored by measuring amount
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b79cbe1697b2dac3465cff1c372b61
https://doi.org/10.1016/0006-2952(84)90107-2
https://doi.org/10.1016/0006-2952(84)90107-2
Publikováno v:
Environmental Health Perspectives
Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6469718e6833b56a136ea9f71a2e2bd4
https://doi.org/10.1289/ehp.8457313
https://doi.org/10.1289/ehp.8457313
Publikováno v:
Toxicology and Applied Pharmacology. 50:581-592
Allylamine, given to adult male rats in drinking water at a concentration of 0.005, 0.05, or 0.1% for 21–104 days, caused dose-dependent myocardial and vascular lesions, although no consistent histopathologic changes were observed in other organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1945d083ff1828860acff6a55a3b941
https://doi.org/10.1016/0041-008x(79)90413-7
https://doi.org/10.1016/0041-008x(79)90413-7