Výsledky vyhledávání - "Edward S. Neiss"

Autor: Stephanie Beling, Max Losi, Robert A Vukovich, Martin Zisblatt, Edmund L Webb, Edward S. Neiss

Publikováno v: American Heart Journal. 106:258-262

Indapamide, 2.5 mg administered once daily for periods up to 36 months, was found to be safe and effective for the long-term control of mild to moderate hypertension. The effects of hydrochlorothiazide, 50 mg, and indapamide, 2.5 mg, were studied in

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https://doi.org/10.1016/0002-8703(83)90126-6

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Chlorthalidone-Triamterene: A Potassium-Sparing Diuretic Combination for the Treatment of Oedema

Autor: Robert Rosenbaum, Edward S. Neiss, Martin Zisblatt, Edmund L Webb, John C Godfrey, Robert A Vukovich

Publikováno v: Journal of International Medical Research. 12:147-153

The efficacy of a once-daily combination of chlorthalidone 50 mg plus triamterene 50 mg or chlorthalidone 100 mg plus triamterene 100 mg was compared to that of chlorthalidone 50 mg or 100 mg. This double-blind study was carried out in eighty-eight p

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https://doi.org/10.1177/030006058401200303

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Absorption and biotransformation of topically applied 8-(methylthio)cyclic AMP

Autor: Terrence W. Mischler, Eric C. Schreiber, Jacques Dreyfuss, J M Shaw, Edward S. Neiss

Publikováno v: British Journal of Dermatology. 93:379-390

SUMMARY 8-(Methylthio)cyclic AMP-35S was applied topically to the intact or abraded skin of dogs at a dose of about 2.5 mg/kg. In this species, an average of 7% of the dose was absorbed through the intact and 62% through abraded skin. Half-lives for

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https://doi.org/10.1111/j.1365-2133.1975.tb06511.x

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REV 2871 (CHBZ): A potent antiallergic agent with a novel mechanism of action

Autor: Howard Jones, Ira Weinryb, Theaddeus Pruss, Atul Khandwala, Stephen M. Coutts, Edward S. Neiss

Publikováno v: Biochemical Pharmacology. 36:663-672

REV 2871 (CHBZ) and its putative metabolite REV 3579-Z (also designated in the literature as RHC 3579-Z) were shown to be potent and orally effective inhibitors of passive cutaneous anaphylaxis (PCA) in the rat (ED 50 = 12 mg/kg). The activity profil

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https://doi.org/10.1016/0006-2952(87)90717-9

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Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids

Autor: Edward S. Neiss, Bernard Loev, Menard Paul, Howard Jones, William S. Mann, John T. Suh, Alfred Schwab, Joyce Wilde

Publikováno v: Journal of Medicinal Chemistry. 28:328-332

A series of (mercaptoaroyl)amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most active compound was N-(3-chloro-2-mercaptobenzoyl)-N-cyclopentylglycine, having an in vitro I

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https://doi.org/10.1021/jm00381a012

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Synthesis and antiallergic activities of 1,3-oxazolo[4,5-h]quinolines

Autor: John H. Musser, S. Sciortino, Mitchell J. Leibowitz, P. Sonnino-Goldman, Kevin Bailey, Atul Khandwala, Howard Jones, Stephen M. Coutts, Edward S. Neiss, P. S. Wolf

Publikováno v: Journal of Medicinal Chemistry. 28:1255-1259

A series of new 1,3-oxazolo[4,5-h]quinolines has been prepared. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated passive cutaneous

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https://doi.org/10.1021/jm00147a023

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Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists

Autor: Thaddeus Pruss, Atul Khandwala, R. G. Van Inwegen, R. J. Gordon, J. H. Musser, Utpal Ranjan Chakraborty, S. Sciortino, I. Weinryb, Stephen M. Coutts, Edward S. Neiss

Publikováno v: Journal of Medicinal Chemistry. 30:96-104

A series of new substituted arylmethyl phenyl ethers has been prepared. These compounds were tested as inhibitors of 5-lipoxygenase (5-LO) in rat neutrophils, in vitro antagonists of leukotriene-induced contraction of guinea pig (GP) lung parenchymal

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https://doi.org/10.1021/jm00384a017

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Arylmethyl Phenyl Ethers

Autor: I. Weinryb, Thaddeus Pruss, J. H. Musser, Vernetta Dally-Meade, N. Jariwala, Richard G. Van Inwegen, John Bruens, Utpal Ranjan Chakraborty, Jones Howard, A. Khandwala, Richard Ingram, Stephen M. Coutts, Edward S. Neiss

Publikováno v: Prostaglandins, Leukotrienes, and Lipoxins ISBN: 9781468449488

Oxidative metabolites of arachidonic acid produced by the 5-lipoxygenase pathway are potent mediators of hypersensitivity and inflammation (see O’Flaherty, 1982; Lewis and Austen, 1984 for reviews). Their proposed roles in the pathophysiology of as

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https://doi.org/10.1007/978-1-4684-4946-4_60

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