Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Edward S. Debnam"'
Autor:
Marija Lesjak, Rukshana Hoque, Sara Balesaria, Vernon Skinner, Edward S Debnam, Surjit K S Srai, Paul A Sharp
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102900 (2014)
Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it m
Externí odkaz:
https://doaj.org/article/facfaa0d469f43e79e4b1bf538186229
Publikováno v:
Experimental Physiology. 102:462-474
To date, the role of the small intestine in regulating post-prandial phosphate homeostasis has remained unclear and controversial. Previous studies have proposed the presence of a gut-derived phosphaturic factor that acts independently of changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75afcb8b6008030fd3707f5675a46b4a
https://doi.org/10.1113/ep086062
https://doi.org/10.1113/ep086062
Autor:
Edward S. Debnam, Joanne Marks, Robert J. Unwin, Mark E. Cleasby, Surjit K. S. Srai, Havovi Chichger
Publikováno v:
Experimental Physiology. 101:731-742
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatment for patients suffering from diabetic nephropathy, the influence of metabolic disruption on the expression and function of glucose transporters is la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639bac5798a931c779cb24d1c54921d2
https://doi.org/10.1113/ep085670
https://doi.org/10.1113/ep085670
Publikováno v:
Experimental physiology. 102(4)
What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43dce2e49f9f706140a78ed2fadecd36
https://pubmed.ncbi.nlm.nih.gov/28130860
https://pubmed.ncbi.nlm.nih.gov/28130860
Autor:
Havovi, Chichger, Mark E, Cleasby, Surjit K, Srai, Robert J, Unwin, Edward S, Debnam, Joanne, Marks
Publikováno v:
Experimental physiology. 101(6)
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatment for patients suffering from diabetic nephropathy, the influence of metabolic disruption on the expression and function of glucose transporters is la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac44050959ce50bc77d3cb74d7de0b50
https://pubmed.ncbi.nlm.nih.gov/27246186
https://pubmed.ncbi.nlm.nih.gov/27246186
Publikováno v:
Physiological Reports
Artificial sweeteners are extensively used by the food industry to replace sugar in food and beverages and are widely considered to be a healthy alternative. However, recent data suggest that artificial sweeteners may impact intestinal glucose absorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe40d3f1ed27badf63efbea29624d79
https://doi.org/10.14814/phy2.13804
https://doi.org/10.14814/phy2.13804
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C601-C610
Streptozotocin-induced (Type 1) diabetes mellitus (T1DM) in rats promotes jejunal glucose transport, but the trigger for this response remains unclear. Our recent work using euglycemic rats has implicated the enterocyte renin-angiotensin system (RAS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff19561a3edcf2f611fbc952174367bf
https://doi.org/10.1152/ajpcell.00135.2009
https://doi.org/10.1152/ajpcell.00135.2009
Autor:
Edward S. Debnam
Publikováno v:
Surgery (Oxford). 26:81-85
The cell membrane is highly permeable to water, but less permeable to solutes. The osmotic activity of fluid surrounding cells influences water movement across the cell membrane and therefore determines the relative volumes of cellular and extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a6640dc36f4ac119b90b04ecb1b079
https://doi.org/10.1016/j.mpsur.2008.02.005
https://doi.org/10.1016/j.mpsur.2008.02.005
Publikováno v:
The Journal of Physiology. 584:613-623
There is increasing evidence that locally produced angiotensin AII (AII) regulates the function of many tissues, but the involvement of enterocyte-derived AII in the control of intestinal transport is unknown. This study examined whether there is a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a663df3d56ed198cd6969ff531cbc9c2
https://doi.org/10.1113/jphysiol.2007.138578
https://doi.org/10.1113/jphysiol.2007.138578
Publikováno v:
Diabetologia. 50:2209-2217
GLUT2 is the main renal glucose transporter upregulated by hyperglycaemia, when it becomes detectable at the brush border membrane (BBM). Since glucose-induced protein kinase C (PKC) activation in the kidney is linked to diabetic nephropathy, we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791fc8a2e7146ff3262f1ae203ef80b4
https://doi.org/10.1007/s00125-007-0778-x
https://doi.org/10.1007/s00125-007-0778-x