Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Edward S, Parsons"'
Autor:
Nita R. Shah, Tomas B. Voisin, Edward S. Parsons, Courtney M. Boyd, Bart W. Hoogenboom, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Cholesterol-dependent cytolysins (CDCs) are bacterial pore-forming virulence factors. Cryo-EM structure of an early conformation of the CDC ILY from Streptococcus intermedius, bound to the human immune receptor CD59, provides insight into ILY oligome
Externí odkaz:
https://doaj.org/article/bad042a16128475abd06082cd212d8e7
Autor:
Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A. Spicer, Ruby H. P. Law, Adrian W. Hodel, Edward S. Parsons, Susan M. Ekkel, Paul J. Conroy, Georg Ramm, Hariprasad Venugopal, Phillip I. Bird, Bart W. Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A. Dunstone, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors
Externí odkaz:
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Edward S. Parsons, George J. Stanley, Alice L. B. Pyne, Adrian W. Hodel, Adrian P. Nievergelt, Anaïs Menny, Alexander R. Yon, Ashlea Rowley, Ralf P. Richter, Georg E. Fantner, Doryen Bubeck, Bart W. Hoogenboom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them
Externí odkaz:
https://doaj.org/article/955c38fbccc64cbdab72da9dedd16f6d
Autor:
Dennis J Doorduijn, Bart W Bardoel, Dani A C Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S Parsons, Bart W Hoogenboom, Suzan H M Rooijakkers
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008606 (2020)
An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C
Externí odkaz:
https://doaj.org/article/e1fbe934824941659ccb044f38ddd1d7
Publikováno v:
Analytical Chemistry
Exosomes are endocytic lipid-membrane bound bodies with the potential to be used as biomarkers in cancer and neurodegenerative disease. The limitations and scarcity of current exosome characterization approaches have led to a growing demand for trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19da492b471da29b517d2cc60fcad07
https://doi.org/10.1021/acs.analchem.9b05736
https://doi.org/10.1021/acs.analchem.9b05736
Autor:
Phillip I. Bird, Bart W. Hoogenboom, Adrian W. Hodel, Georg Ramm, Susan M. Ekkel, Hariprasad Venugopal, Charles Bayly-Jones, Mazdak Radjainia, Ilia Voskoboinik, Ruby H. P. Law, Paul J. Conroy, Yann Gambin, Siew Siew Pang, Michelle A. Dunstone, Emma Sierecki, Bradley A. Spicer, Edward S. Parsons, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d562c790b77ea9ee8829a74700201af
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Katharine, Hammond, Georgina, Benn, Isabel, Bennett, Edward S, Parsons, Maxim G, Ryadnov, Bart W, Hoogenboom, Alice L B, Pyne
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2208
Recent advances in biomolecular design require accurate measurements performed in native or near-native environments in real time. Atomic force microscopy (AFM) is a powerful tool to observe the dynamics of biologically relevant processes at aqueous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f3da30a7ce36f8d261ff6da63fbf491
https://pubmed.ncbi.nlm.nih.gov/32856266
https://pubmed.ncbi.nlm.nih.gov/32856266
Autor:
Alice L. B. Pyne, Katharine Hammond, Maxim G. Ryadnov, Edward S. Parsons, Georgina Benn, Isabel Bennett, Bart W. Hoogenboom
Publikováno v:
Methods in Molecular Biology ISBN: 9781071609279
Recent advances in biomolecular design require accurate measurements performed in native or near-native environments in real time. Atomic force microscopy (AFM) is a powerful tool to observe the dynamics of biologically relevant processes at aqueous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4eba308f9769b21a2e010bbda362eb6
https://doi.org/10.1007/978-1-0716-0928-6_15
https://doi.org/10.1007/978-1-0716-0928-6_15
Autor:
Courtney M. Boyd, Tomas B. Voisin, Nita R. Shah, Bart W. Hoogenboom, Edward S. Parsons, Doryen Bubeck
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Cholesterol-dependent cytolysins (CDCs) are pore-forming proteins that serve as major virulence factors for pathogenic bacteria. They target eukaryotic cells using different mechanisms, but all require the presence of cholesterol to pierce lipid bila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab7e3ee7b3a761a39ad3a408771ed86
https://doi.org/10.1101/2020.06.16.154724
https://doi.org/10.1101/2020.06.16.154724
Autor:
Suzan HM Rooijakkers, Bart Hoogenboom, Edward S Parsons, Georgina Benn, Maartje Ruyken, Dani AC Heesterbeek, Bart W Bardoel, Dennis J Doorduijn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9e376538310334ae14a6b66935e15b
https://doi.org/10.15252/rc.2022106179
https://doi.org/10.15252/rc.2022106179