Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Edward R. Kastenhuber"'
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Timothy A. Dinh, Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, Edward R. Kastenhuber, Eliane Wauthier, Cynthia D. Guy, Raymond S. Yeung, Scott W. Lowe, Lola M. Reid, John D. Scott, Anna M. Diehl, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 803-817 (2019)
Background & Aims: Fibrolamellar carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous approximately 400-kb deletion on chromosome 19 that results in a unique fusion between
Externí odkaz:
https://doaj.org/article/7c0b575b397444a8aec84eb5e9313d8a
Autor:
Edward R Kastenhuber, Marisa Mercadante, Benjamin Nilsson-Payant, Jared L Johnson, Javier A Jaimes, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Vasuretha Chandar, Gary R Whittaker, Benjamin R tenOever, Robert E Schwartz, Lewis Cantley
Publikováno v:
eLife, Vol 11 (2022)
Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be importan
Externí odkaz:
https://doaj.org/article/1ff37db056a54d4d8ee1c896a12329b4
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Publikováno v:
Nature. 613:759-766
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and se
Autor:
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Publikováno v:
Cancer Discovery. 13:146-169
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
ChIP-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17caa0aa8fb1356b5a7ce1ae746170e7
https://doi.org/10.1158/2159-8290.22542055
https://doi.org/10.1158/2159-8290.22542055
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Sequences of sgRNAs and primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcda721a657db3047fd126e2892aadd
https://doi.org/10.1158/2159-8290.22542061
https://doi.org/10.1158/2159-8290.22542061
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f9a27688c8427afa406f20015bed3
https://doi.org/10.1158/2159-8290.c.6549793
https://doi.org/10.1158/2159-8290.c.6549793
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
RNA-Seq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42753da56fe296de83bbedd0357e9a1f
https://doi.org/10.1158/2159-8290.22542052
https://doi.org/10.1158/2159-8290.22542052
Autor:
C. David Allis, Scott W. Lowe, Scott A. Armstrong, Richard M. Stone, Elisa de Stanchina, Maximiliano Meneses, Andrei V. Krivtsov, X. Shirley Liu, Shengqing Gu, David Cheon, Mary Clare Beytagh, Leah Gates, Alexey A. Soshnev, Disha Anand, Yijun Xiong, Thomas Carroll, Yu-Jui Ho, Edward R. Kastenhuber, Douglas W. Barrows, Florian Perner, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano
CRISPR screen results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0028c2acb2959b0e069ce9a57ca288
https://doi.org/10.1158/2159-8290.22542058.v1
https://doi.org/10.1158/2159-8290.22542058.v1