Výsledky vyhledávání - "Edward R. Jack"

Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

Autor: David A. Middleton, Photini Sinnis, Bridie A. Kelly, Curtis B. Dobson, Stuart J. D. Neil, Edward R. Jack, Joana M. Santos, Áine McKnight

Publikováno v: FEBS Journal. 274:4511-4525

Host-derived anti-infective proteins represent an important source of sequences for designing antimicrobial peptides (AMPs). However such sequences are often long and comprise diverse amino acids with uncertain contribution to biological effects. Pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::977fe84306fcdf903eba2558928fb1ae
https://doi.org/10.1111/j.1742-4658.2007.05981.x

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Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

Autor: Peter G. Stockley, Louise C. Serpell, David A. Middleton, Sheena E. Radford, Jillian Madine, Edward R. Jack

Publikováno v: Journal of the American Chemical Society. 130(45)

Many unrelated proteins and peptides can assemble into amyloid or amyloid-like nanostructures, all of which share the cross-beta motif of repeat arrays of beta-strands hydrogen-bonded along the fibril axis. Yet, paradoxically, structurally polymorphi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a3aa9f7646245cc6693e42a3ed86e8
https://pubmed.ncbi.nlm.nih.gov/18937465

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Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues

Autor: Edward R. Jack, Jillian Madine, Lu-yun Lian, David A. Middleton

Publikováno v: Molecular membrane biology. 25(1)

Rho GTPases are a multifunctional family of proteins that are localized at cellular membranes via an isoprenyl group covalently linked to a C-terminal cysteine. Close to this primary site of membrane anchoring there is often found an additional polyb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9e8dd0ea333e68e8012902a351ef44
https://pubmed.ncbi.nlm.nih.gov/18097952

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Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

Autor: Bridie A, Kelly, Stuart J, Neil, Aine, McKnight, Joana M, Santos, Photini, Sinnis, Edward R, Jack, David A, Middleton, Curtis B, Dobson

Publikováno v: The FEBS journal. 274(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37d8ab28f84169445631d7fe4f00dcac
https://pubmed.ncbi.nlm.nih.gov/17681018

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The organization of aromatic side groups in an amyloid fibril probed by solid-state 2H and 19F NMR spectroscopy

Autor: David A. Middleton, Peter G. Stockley, Edward R. Jack, Matthew Newsome, Sheena E. Radford

Publikováno v: Journal of the American Chemical Society. 128(25)

Some 25 diseases are associated with proteins and peptides that assemble into amyloid fibrils composed of beta-strands connected by hydrogen bonds oriented parallel to the fiber long axis. There is mounting evidence that amyloid formation involves sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a9525a31f9d271d3cfa5462ead0957
https://pubmed.ncbi.nlm.nih.gov/16787049

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