Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Edward R. Bowman"'
Autor:
Stephen M. Husbands, Jillian Helen Broadbear, John Sadd, Jason Martin, John R. Traynor, Louis S. Harris, Mario D. Aceto, James H. Woods, Edward R. Bowman, John W. Lewis
Publikováno v:
Journal of Medicinal Chemistry. 41:3493-3498
In recent years there has been considerable interest in the relationship between clocinnamox (C-CAM) and its methyl ether methoclocinnamox (MC-CAM). While C-CAM appears to be an insurmountable mu-antagonist, MC-CAM has been shown to be a potent parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06edf6e36232f59fc3ae4fb5f0ce70ba
https://doi.org/10.1021/jm9810248
https://doi.org/10.1021/jm9810248
Publikováno v:
European Journal of Pharmacology. 338:215-223
Comparative analgesic studies revealed that dihydroetorphine was more potent than etorphine in the tail-flick and hot-plate tests, respectively and nearly equipotent in the phenylquinone assay. Both compounds were short acting. Studies with selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33c2e5d6f9702b1bab2a56d312b8fa
https://doi.org/10.1016/s0014-2999(97)81924-3
https://doi.org/10.1016/s0014-2999(97)81924-3
Autor:
Charles B. Smith, Louis S. Harris, William L. Woolverton, Mariena V. Mattson, Eduardo R. Butelman, James H. Woods, James K. Rowlett, and Arthur E. Jacobson, G. A. Patrick, Justin A. English, Edward R. Bowman, Gail Winger, Fedor Medzihradsky, M.D. Acteo
Publikováno v:
Drug and Alcohol Dependence. 42:93-104
Zipeprol was evaluated in a number of in vitro and in vivo assays predictive of stimulant, depressant, or opioid abuse potential. Zipeprol had affinity for β and κ opioid binding sites as well as δ binding sites. However, it failed to exert opioid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afdb7b84c341b659aeb528a1cc48494
https://doi.org/10.1016/0376-8716(96)01267-7
https://doi.org/10.1016/0376-8716(96)01267-7
Publikováno v:
Journal of Analytical Toxicology. 19:571-575
From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46122d1365f26c01d5dfb2c86affaac4
https://doi.org/10.1093/jat/19.7.571
https://doi.org/10.1093/jat/19.7.571
Autor:
Everette L. May, Mario D. Aceto, Edward R. Bowman, Louis S. Harris, James H. Woods, John R. Traynor, Andrew Coop
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:31-33
To further investigate the unusual profile of N-benzyl substituted opioids, N-trifluoromethylbenzyl normetazocines and norketobemidones were prepared. The introduction of trifluoromethyl substituents on the benzyl group of the (-)-metazocines reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b955f501b32cb2d0b656d6c0e07d447b
https://doi.org/10.1016/s0968-0896(02)00435-2
https://doi.org/10.1016/s0968-0896(02)00435-2
Publikováno v:
Brain Research. 644:117-127
Many epidemiological studies have suggested a high correlation between the use of tobacco and ethanol, the two most frequently abused psychoactive drugs. Recently, we reported behavioral interactions between (-)-nicotine, (-)-cotinine and ethanol wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b6e6ae2efda9374641d7ab795a8695
https://doi.org/10.1016/0006-8993(94)90354-9
https://doi.org/10.1016/0006-8993(94)90354-9
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 19:41-46
This study was designed to characterize the cocaine-induced rausch or hyperarousal syndrome in rhesus monkeys. This syndrome mimics the stage observed in human abusers bingeing on cocaine and is considered crucial in the progression from recreational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524d2bf22e4f3ed469de2fec6328b249
https://doi.org/10.1007/bf03188822
https://doi.org/10.1007/bf03188822
Autor:
Louis S. Harris, Jennifer L Newman, Patrick M. Beardsley, Charles D. Cook, Mario D. Aceto, Edward R. Bowman
Publikováno v:
Experimental and clinical psychopharmacology. 12(3)
Despite oxycodone's (4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one) history of clinical use and the attention it has received as a drug of abuse, few reports have documented its pharmacology's relevance to its abuse or its mechanism of acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bea1e4e805fe4a670c792c7a3ff868b
https://pubmed.ncbi.nlm.nih.gov/15301633
https://pubmed.ncbi.nlm.nih.gov/15301633
Publikováno v:
European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 248:333-335
Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477c71c0205d4a571ee572bfbf231dee
https://doi.org/10.1016/0926-6917(93)90009-f
https://doi.org/10.1016/0926-6917(93)90009-f
Autor:
Everette L. May, Mariena V. Mattson, Christine Bentley, Arthur E. Jacobson, Edward R. Bowman, Louis S. Harris, Fedor Medzihradsky, Billy R. Martin, Mario D. Aceto
Publikováno v:
Journal of medicinal chemistry. 37(20)
The enantiomeric (-)- and (+)-N-(methyl through decyl) normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans) were synthesized and their in vitro and in vivo activities determined. Increasingly bulky enantiomeric N-alkyl homologs were prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf8290dabb8fb519488d8e37339c5d9
https://pubmed.ncbi.nlm.nih.gov/7932569
https://pubmed.ncbi.nlm.nih.gov/7932569