Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Edward R Sherwood"'
Autor:
Charles E Bane, Ivan Ivanov, Anton Matafonov, Kelli L Boyd, Qiufang Cheng, Edward R Sherwood, Erik I Tucker, Stephen T Smiley, Owen J T McCarty, Andras Gruber, David Gailani
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152968 (2016)
Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed
Externí odkaz:
https://doaj.org/article/15e4234e34084d13b6001a61916bc58a
Autor:
Naeem K Patil, Liming Luan, Julia K Bohannon, Yin Guo, Antonio Hernandez, Benjamin Fensterheim, Edward R Sherwood
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148452 (2016)
BACKGROUND:Severely burned patients are highly susceptible to opportunistic infections and sepsis, owing to the loss of the protective skin barrier and immunological dysfunction. Interleukin-15 (IL-15) belongs to the IL-2 family of common gamma chain
Externí odkaz:
https://doaj.org/article/f97b78eadb6e4ae690d1c70b47ee69ef
Autor:
Perenlei Enkhbaatar, Christina Nelson, John R Salsbury, Joseph R Carmical, Karen E O Torres, David Herndon, Donald S Prough, Liming Luan, Edward R Sherwood
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144345 (2015)
Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in rodents have demonstrated the efficacy of TLR4 agonists as immunomodulators in models of infect
Externí odkaz:
https://doaj.org/article/2c19cc975bf0431bb2d5beb3e19ee67e
Autor:
Allison M. Owen, Liming Luan, Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Olivia A. Boykin, Kalkena Sivanesam, Jessica F. Schaedel, Tazeen K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. Patil, Edward R. Sherwood, Julia K. Bohannon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming
Externí odkaz:
https://doaj.org/article/1bdb214cdc2741c5a7e817eceb2d01ff
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a
Externí odkaz:
https://doaj.org/article/227ddbaf4cfd4dbfbd351ec7dc33fed6
Autor:
Antonio Hernandez, Naeem K. Patil, Maya Brewer, Rachel Delgado, Lauren Himmel, Lauren N. Lopez, Julia K. Bohannon, Allison M. Owen, Edward R. Sherwood, Mark P. de Caestecker
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F472-F482
Pretreatment with 3-deacyl 6-acyl phosphorylated hexaacyl disaccharide; a novel synthetic Toll-like receptor 4 agonist, preserves kidney function during ischemia-reperfusion injury-induced acute kidney injury.
Autor:
Antonio Hernandez, Jing Zhou, Julia K. Bohannon, Margaret A. McBride, Katherine N. Gibson-Corley, Naeem K. Patil, Allison M. Owen, Katherine R. Burelbach, Edward R. Sherwood
Publikováno v:
Shock. 58:295-303
Objectives: Nosocomial pneumonia is a common complication in critically ill patients. The goal of this study was to examine the efficacy of the Toll-like receptor 4 agonist 3-deacyl phosphorylated hexacyl disaccharide (3D PHAD), in a clinically relev
Autor:
Edward R. Sherwood, Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Allison M. Owen, Antonio Hernandez, Naeem K. Patil, David L. Williams, Julia K. Bohannon
Publikováno v:
The Journal of Immunology. 208:785-792
Unlike the adaptive immune system, the innate immune system has classically been characterized as being devoid of memory functions. However, recent research shows that innate myeloid and lymphoid cells have the ability to retain memory of prior patho
Autor:
Liming Luan, Margaret A. McBride, Tazeen K. Patil, David L. Williams, Cody L. Stothers, Katherine R. Burelbach, Antonio Hernandez, Allison M. Owen, Edward R. Sherwood, Julia K. Bohannon, Naeem K. Patil
Publikováno v:
J Immunol
Bacterial infections are a common and deadly threat to vulnerable patients. Alternative strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the fungal cell wall, provokes resistance to infection by inducing trained im
Autor:
Edward R. Sherwood, Julia K. Bohannon
Publikováno v:
Shock. 55:419-422