Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Edward Pearlstein"'
Publikováno v:
International Journal of Cancer. 31:463-469
Because tumor-induced platelet aggregation appears to play a role in the development of certain experimental tumor metastases, we examined the mechanism(s) of tumor-induced platelet aggregation as well as the effect of various anti-platelets agents.
Autor:
Edward Pearlstein, Leslie I. Gold
Publikováno v:
Biochemical Journal. 186:551-559
Fibronectin isolated from human plasma and from the extracellular matrices of cell monolayers mediates the attachment in vitro and spreading of trypsin-treated cells on a collagen substratum. Fibronectin-dependent kinetics of cellular attachment to c
Autor:
Edward Pearlstein
Publikováno v:
Nature. 262:497-500
DEFECTS in cell behaviour associated with malignancy may be causally related to alterations in the plasma membrane of the cell on transformation1. Much interest has focused on a protein found on the surface of normal but not transformed cells 2–7.
Publikováno v:
Biochemical and Biophysical Research Communications. 120:1015-1021
The carboxy terminal fragment of human plasma fibronectin has been isolated after tryptic digestion and separation by DEAE-cellulose chromatography and gel filtration on Sephadex G-50. It has a molecular weight of 6,000 which changes to 3,000 after r
Autor:
Edward Pearlstein
Publikováno v:
International Journal of Cancer. 22:32-35
Cell Adhesion Factor, complexed to insoluble collagen-coated tissue culture dishes, is required for the attachment of fibroblasts to this substrate. In solution, the factor has no demonstrable affinity for cells in suspension following trypsin-EDTA r
Publikováno v:
Journal of Clinical Investigation. 81:1012-1019
Platelet-adhesive protein-tumor cell interaction was studied in vitro and in vivo. Monoclonal antibody 10E5, which inhibits binding of fibronectin and von Willebrand factor to the platelet membrane glycoprotein GPIIb-GPIIIa complex, inhibited the bin
Publikováno v:
Biochemical and Biophysical Research Communications. 140:12-20
Fibronectin has been shown to play an important role in reticuloendothelial system functioning as well as in neutrophil and fibroblast migration to tissue injury sites. Fibronectin binds several macromolecules including components of the acute phase
Publikováno v:
Proceedings of the National Academy of Sciences. 77:4336-4339
Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma have been examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platele
Publikováno v:
Journal of Cell Science. 50:315-327
Although adherence to surfaces is central to neutrophil function many of the determinants of neutrophil adherence are still unknown. The possible involvement of cell surface material, fibronectin in particular, was therefore studied. Surface coat mat
Autor:
Edward Pearlstein, Sylvia Hoffstein
Publikováno v:
Experimental Cell Research. 134:161-170
Although fibronectin has been well established as a mediator of cell adherence in vitro and has therefore been presumed to play a role as such in vivo, the ability of fibronectin, laid down in vivo, to mediate cell attachment, has not been demonstrat