Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Edward P. Bowman"'
Autor:
Akiko Hashimoto-Tane, Edward P. Bowman, Machie Sakuma, Natsumi Yoneda, Katsuyuki Yugi, Rene de Waal Malefyt, Takashi Saito
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte activation gene (Lag)-3 is an inhibitory co-receptor and target of immune checkpoint inhibitor (ICI) therapy for cancer. The dynamic behavior of Lag-3 was analyzed at the immune synapse upon T-cell activation to elucidate the Lag-3 inhibit
Externí odkaz:
https://doaj.org/article/01488bb5ac8c4a6ab38ab7b584d9ff15
Autor:
David Bauché, Smita Mauze, Christina Kochel, Jeff Grein, Anandi Sawant, Yulia Zybina, Lakshmanan Annamalai, Jennifer H Yearley, Juha Punnonen, Edward P Bowman, Alissa Chackerian, Drake Laface
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Programmed cell death protein 1 (PD-1) and CTLA4 combination blockade enhances clinical efficacy in melanoma compared with targeting either checkpoint alone; however, clinical response improvement is coupled with increased risk of developi
Externí odkaz:
https://doaj.org/article/1bda0443d10a44cca19b501ab433abcf
Autor:
Rob C. Oslund, Tamara Reyes-Robles, Cory H. White, Jake H. Tomlinson, Kelly A. Crotty, Edward P. Bowman, Dan Chang, Vanessa M. Peterson, Lixia Li, Silvia Frutos, Miquel Vila-Perelló, David Vlerick, Karen Cromie, David H. Perlman, Sampat Ingale, Samantha D. O’ Hara, Lee R. Roberts, Grazia Piizzi, Erik C. Hett, Daria J. Hazuda, Olugbeminiyi O. Fadeyi
Publikováno v:
Nature Chemical Biology. 18:850-858
Autor:
Renu Jain, Daniel J. Cua, Amy M. Beebe, Edward P. Bowman, Jane Xia, Barbara Joyce-Shaikh, Smita Mauze, Ashley E. Mahne
Agonistic monoclonal antibodies (mAb) targeting the T-cell receptor coregulatory molecule GITR exert potent therapeutic activities in preclinical tumor models. Although anti-GITR mAb are thought to act by depleting and destabilizing the intratumoral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981bd21ef7d17b20d8714f271ff1f6c8
https://doi.org/10.1158/0008-5472.c.6509418.v1
https://doi.org/10.1158/0008-5472.c.6509418.v1
Autor:
Renu Jain, Daniel J. Cua, Amy M. Beebe, Edward P. Bowman, Jane Xia, Barbara Joyce-Shaikh, Smita Mauze, Ashley E. Mahne
Supplementary Materials and Methods include Treg lineage tracing data in B16 melanoma tumor model and binding, pharmacokinetics characterization and agonist signaling activity data for mDTA-1 Fc mutant antibody.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac176463991410d7d89b3b66898ce5f
https://doi.org/10.1158/0008-5472.22415922.v1
https://doi.org/10.1158/0008-5472.22415922.v1
Autor:
Grazia Piizzi, Karen Cromie, Samantha D. O’Hara, Rob C. Oslund, Kelly A. Crotty, Vanessa M. Peterson, Lee R. Roberts, Daria J. Hazuda, Cory H. White, Erik C. Hett, Tamara Reyes-Robles, David H. Perlman, Dan Chang, David Vlerick, Silvia Frutos, Olugbeminiyi O. Fadeyi, Edward P. Bowman, Jake H. Tomlinson, Miquel Vila-Perelló, Lixia Li
Cell-cell interactions drive essential biological processes critical to cell and tissue development, function, pathology, and disease outcome. The growing appreciation of immune cell interactions within disease environments has led to significant eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be94bbf6f8e3c3e1350c37ea44680a31
https://doi.org/10.1101/2021.10.04.463039
https://doi.org/10.1101/2021.10.04.463039
Autor:
Juha Punnonen, Lakshmanan Annamalai, Edward P. Bowman, Peng Yang, Drake LaFace, Jennifer H. Yearley, Anandi Sawant, Alissa A. Chackerian, Smita Mauze, Jeff Grein, Wendy M. Blumenschein, David Bauché, Yulia Zybina, Christina Kochel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundProgrammed cell death protein 1 (PD-1) and CTLA4 combination blockade enhances clinical efficacy in melanoma compared with targeting either checkpoint alone; however, clinical response improvement is coupled with increased risk of developin
Autor:
Derek Wiswell, Enrique Escandón, Alissa A. Chackerian, Shuli Zhang, Edward P. Bowman, Divas Neupane, Anandi Sawant, Douglas Linn, Minchao Chen
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 103:106872
Undesired immune responses against protein therapeutics may adversely affect the pharmacokinetics, efficacy, and safety of the product. The presence of anti-drug-antibodies (ADA) has been the key determinant of immunogenic responses. Here we describe
Autor:
Diana Montgomery, Anish Mehta, Elisabeth Riedl, Christine Bangert, Ann Horowitz, Frank van Aarle, Tamara Kopp, Xiaoli Shirley Hou, Elli K. Greisenegger, Sauzanne Khalilieh, Thomas Marbury, Wendy M. Blumenschein, Anthe S. Zandvliet, Edward P. Bowman, Claus Zachariae, Danlin Xu, Harald Kittler, Terrill K. McClanahan
Publikováno v:
Nature. 521:222-226
A proof-of-concept phase I clinical trial demonstrates that targeting interleukin (IL)-23 with an antibody that binds to the p19 subunit leads to clinical improvement of disease in patients with moderate to severe psoriasis. Sauzanne Khalilieh and co
Autor:
Jian Wu, Ritu Sarin, Neha Dixit, Edward P. Bowman, M. Eric Gershwin, Hyun-Seock Shin, Iannis E. Adamopoulos
Publikováno v:
The Journal of Immunology. 194:316-324
IL-23 has been well studied in the context of T cell differentiation; however, its role in the differentiation of myeloid progenitors is less clear. In this paper, we describe a novel role of IL-23 in myeloid cell differentiation. Specifically, we ha