Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Edward Metzger"'
Autor:
Edward Metzger, Margaret E. C. Ginoza
Publikováno v:
Reptiles & Amphibians. 28:558-559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd1495866b9b5ae452f1fcdb3108a94a
https://doi.org/10.17161/randa.v28i3.15883
https://doi.org/10.17161/randa.v28i3.15883
Autor:
Emma B. Hanslowe, Robert N. Reed, Raymond W. Snow, Edward Metzger, James G. Duquesnel, Bryan G. Falk, Amy A. Yackel Adams, Michelle A. M. Collier
Publikováno v:
Management of Biological Invasions. 9:369-377
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed086de16b45700ca9415d200ba1159
https://doi.org/10.3391/mbi.2018.9.3.18
https://doi.org/10.3391/mbi.2018.9.3.18
Autor:
Rolf W. Hartmann, Qingzhong Hu, Amjad Ali, Edward Metzger, Juliette Emmerich, Lina Yin, Michael Man-Chu Lo
Publikováno v:
Journal of Medicinal Chemistry. 57:5179-5189
Pathologically, high levels of aldosterone are associated with severe cardiovascular diseases such as congestive heart failure, hypertension, and myocardial fibrosis. The inhibition of aldosterone synthase (CYP11B2) to reduce aldosterone levels has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9085a09a470f89a85f0cb9a9ae3a4190
https://doi.org/10.1021/jm500140c
https://doi.org/10.1021/jm500140c
Autor:
Qingzhong Hu, Scott B. Hoyt, Paul Ratcliffe, Michael Man-Chu Lo, Amjad Ali, Rolf W. Hartmann, Edward Metzger, Jonathan Bennett, Lina Yin, Andrew J. Cooke
Publikováno v:
Journal of medicinal chemistry. 58(5)
CYP11B2 inhibition is a promising treatment for diseases caused by excessive aldosterone. To improve the metabolic stability in human liver miscrosomes of previously reported CYP11B2 inhibitors, modifications were performed via a combination of ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a167ca9bad459bc327adb61ea53b89
https://pubmed.ncbi.nlm.nih.gov/25711516
https://pubmed.ncbi.nlm.nih.gov/25711516
Autor:
Dominick F. Gratale, James V. Heck, David E. Moller, Karen L. MacNaul, Hiroo Koyama, Edward Metzger, Soumya P. Sahoo, Victoria K. Lombardo, Ronald B. Franklin, Thomas W. Doebber, Wei Han, Joel P. Berger, Ranjit C. Desai, Kwan Leung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3541-3544
A series of novel aryloxazolidine-2,4-diones was synthesized. A structure–activity relationship study of these compounds led to the identification of potent, orally active PPAR dual α/γ agonists. Based on the results of efficacy studies in the db
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f648cc526319a858cb2f0fdb3f282753
https://doi.org/10.1016/s0960-894x(03)00785-6
https://doi.org/10.1016/s0960-894x(03)00785-6
Autor:
Jane-L. Lo, Alan D. Adams, Samuel D. Wright, Edward Metzger, Jinghua Yu, Li Huang, Jisong Cui, Peter T. Meinke, Annie Zhao
Publikováno v:
Journal of Biological Chemistry. 277:31441-31447
Bile salt export pump (BSEP) is a major bile acid transporter in the liver. Mutations in BSEP result in progressive intrahepatic cholestasis, a severe liver disease that impairs bile flow and causes irreversible liver damage. BSEP is a target for inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec53174db1941d2ef3f864ee6b372b7
https://doi.org/10.1074/jbc.m200474200
https://doi.org/10.1074/jbc.m200474200
Autor:
David E. Moller, Wei Han, James V. Heck, Edward Metzger, Karen L. MacNaul, Kwan Leung, Ranjit C. Desai, Thomas W. Doebber, Soumya P. Sahoo, Joel P. Berger, Jeffrey P. Bergman, Dominick F. Gratale
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARalpha/gamma agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069335c04e1cc96573d58ad9e635aea6
https://pubmed.ncbi.nlm.nih.gov/12873517
https://pubmed.ncbi.nlm.nih.gov/12873517
Autor:
Jeffrey P. Bergman, Joel P. Berger, Dominick F. Gratale, Daniel J. Miller, James V. Heck, Julia K. Boueres, Wei Han, Soumya P. Sahoo, Hiroo Koyama, Kwan Leung, David E. Moller, Thomas W. Doebber, Edward Metzger, Karen L. MacNaul, Richard L. Tolman
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(10)
A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e505ccc834618162c58c60605bfea1
https://pubmed.ncbi.nlm.nih.gov/12729668
https://pubmed.ncbi.nlm.nih.gov/12729668
Autor:
Dominick F. Gratale, James V. Heck, Ranjit C. Desai, Joel P. Berger, Kwan Leung, Wei Han, David E. Moller, Karen L. MacNaul, Soumya P. Sahoo, Ronald B. Franklin, Victoria K. Lombardo, Hiroo Koyama, Edward Metzger, Thomas W. Doebber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae33d7a904ec97d38a51f28dac8e7cbd
https://doi.org/10.1016/j.bmcl.2003.10.001
https://doi.org/10.1016/j.bmcl.2003.10.001