Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Edward M. Suh"'
Autor:
Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W. Northfelt, Matthew P. Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M. Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis, Cynthia X. Ma
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in p
Externí odkaz:
https://doaj.org/article/e2effa9a641b4f7696e08654cd042fb5
Autor:
Judy Oestreicher, Edward M. Suh, Cheryl H. Baker, Tara P. Pitts, Qunli Xu, Priscilla L. Winder, Patricia Linley, Kaoru Mitsuhashi, Amy E. Wright, Karen TenDyke, Esther A. Guzmán
Publikováno v:
International Journal of Cancer. 139:2116-2126
Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis occurs before symptoms manifest. Leiodermatolide, a polyketide macrolide with antimitotic activity isolated from a deep wate
Autor:
Jeremy Hoog, Ning Liu, Andres Forero, Cynthia X. Ma, Matthias Bergqvist, Donald W. Northfelt, Shana Thomas, Souzan Sanati, Matthew J. Ellis, Edward M Suh, Magnus Neumuller, Kiran Vij, Jingqin Luo, Nusayba Bagegni, Matthew P. Goetz, Zhanfang Guo, Jakob Karen
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 19, Iss 1, Pp 1-11 (2017)
Breast Cancer Research, Vol 19, Iss 1, Pp 1-11 (2017)
Background Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in patients w
Autor:
Esther A, Guzmán, Qunli, Xu, Tara P, Pitts, Kaoru Ogawa, Mitsuhashi, Cheryl, Baker, Patricia A, Linley, Judy, Oestreicher, Karen, Tendyke, Priscilla L, Winder, Edward M, Suh, Amy E, Wright
Publikováno v:
International journal of cancer. 139(9)
Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis occurs before symptoms manifest. Leiodermatolide, a polyketide macrolide with antimitotic activity isolated from a deep wate
Autor:
Ende Pan, Richard Randrianaivo, Edward M. Suh, Peggy J. Brodie, Karen TenDyke, Yongchun Shen, David G. I. Kingston, Stephan Rakotonandrasana, Shugeng Cao, Vincent E. Rasamison, Etienne Rakotobe, Martin W. Callmander
Publikováno v:
Journal of Natural Products. 74:1169-1174
In our continuing search for biologically active natural products from tropical forests as part of an International Cooperative Biodiversity Group (ICBG) program, we obtained an EtOH extract from the roots of a plant identified as Ambavia gerrardii (
Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest
Autor:
Vincent E. Rasamison, Shugeng Cao, Richard Randrianaivo, Yanpeng Hou, Etienne Rakotobe, David G. I. Kingston, Peggy J. Brodie, Fidisoa Ratovoson, Martin W. Callmander, Stephan Rakotonandrasana, Karen TenDyke, Edward M. Suh
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2215-2218
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of Elaeodendron alluaudianum led to the isolation of two new cardenolide glycosides ( 1 and 2 ). The 1 H and 13 C NMR spectra of both compounds were fully assigned using a
Autor:
Chris Birkinshaw, David G. I. Kingston, Peggy J. Brodie, Edward M. Suh, Fidy Ratovoson, Shugeng Cao, Etienne Rakotobe, Brian T. Murphy, James S. Miller, Vincent E. Rasamison, Karen TenDyke
Publikováno v:
Natural Product Research. 22:1169-1175
Bioassay-guided fractionation of an ethanol extract of Artabotrys madagascariensis led to the isolation of the new compound artabotrene (1), two butenolides (2 and 3), and the tetracyclic triterpene polycarpol (4). Structure elucidation was determine
Autor:
Chris Birkinshaw, Rabodo Andriantsiferana, Peggie Brodie, Carla Slebodnick, Vincent E. Rasamison, Brian T. Murphy, Edward M. Suh, James S. Miller, Lucien M. Randrianjanaka, David G. I. Kingston, Karen TenDyke
Publikováno v:
Journal of Natural Products. 71:325-329
Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was ca
Autor:
James S. Miller, Sennen Randrianasolo, Etienne Rakotobe, Peggy J. Brodie, Fidy Ratovoson, David G. I. Kingston, Vincent E. Rasamison, Karen TenDyke, Edward M. Suh, Martin W. Callmander, Shugeng Cao
Publikováno v:
Journal of Natural Products. 70:1064-1067
Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and
Autor:
Edward M. Suh, Robert J. Distel, Joseph W. Gibson, Smaranda Bacanu, Magnus Neumuller, Geoffrey I. Shapiro, Sara Lööf, John Hilton, Pawel Niekrasz, Leena Gandhi, Nicole G. Chau, Takahiro Seki, Khan Do, Mattias Bergqvist
Publikováno v:
Cancer Research. 77:2340-2340
Selective CDK4/6 inhibition is now part of standard treatment for HR+ breast cancer. There is a pressing need for a practical biomarker that can provide early indication of the biologic activity of these agents and correlate with clinical outcome. Ex