Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Edward M. Postlethwait"'
Autor:
Whitney S. Theis, Kelly K. Andringa, Telisha Millender-Swain, Dale A. Dickinson, Edward M. Postlethwait, Shannon M. Bailey
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 52-60 (2014)
Ozone (O3) is a serious public health concern. Recent findings indicate that the damaging health effects of O3 extend to multiple systemic organ systems. Herein, we hypothesize that O3 inhalation will cause downstream alterations to the liver. To tes
Externí odkaz:
https://doaj.org/article/9d10b4bf35b84067a46fc594ba45c50a
Autor:
Candice C Clay, Kinjal Maniar-Hew, Joan E Gerriets, Theodore T Wang, Edward M Postlethwait, Michael J Evans, Justin H Fontaine, Lisa A Miller
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90401 (2014)
Exposure to ozone has been associated with increased incidence of respiratory morbidity in humans; however the mechanism(s) behind the enhancement of susceptibility are unclear. We have previously reported that exposure to episodic ozone during postn
Externí odkaz:
https://doaj.org/article/af9bf708e72d4cc38bc8b68447dab84b
Autor:
Francisco J. Schopfer, Sonia R. Salvatore, Edward M. Postlethwait, Bruce A. Freeman, Gerardo Ferrer-Sueta, Marco Fazzari, Jack R. Lancaster, Dario A. Vitturi, Lucia Minarrieta
Publikováno v:
Nature chemical biology
The current perspective holds that the generation of secondary signaling mediators from nitrite (NO2(-)) requires acidification to nitrous acid (HNO2) or metal catalysis. Herein, the use of stable isotope-labeled NO2(-) and LC-MS/MS analysis of produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794ef52da2d2d3ad484fd2bcf0339169
https://doi.org/10.1038/nchembio.1814
https://doi.org/10.1038/nchembio.1814
Autor:
Shannon M. Bailey, Dale A. Dickinson, Edward M. Postlethwait, Kelly K. Andringa, Whitney S. Theis, Telisha Millender-Swain
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 52-60 (2014)
Redox Biology
Redox Biology
Ozone (O3) is a serious public health concern. Recent findings indicate that the damaging health effects of O3 extend to multiple systemic organ systems. Herein, we hypothesize that O3 inhalation will cause downstream alterations to the liver. To tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf63461aa8de9a30513c60fe6511c21
Autor:
Chad Steele, Jaideep Honavar, Stephen F. Doran, Chad W. Dunaway, Rakesh P. Patel, Yanping Liu, Andrey A. Samal, Edward M. Postlethwait, Angela Brandon, Giuseppe L. Squadrito, Michelle V. Fanucchi, Sadis Matalon, Kelley M. Bradley
Publikováno v:
Free Radical Biology and Medicine. 53:1431-1439
Cl2 gas toxicity is complex and occurs during and after exposure, leading to acute lung injury (ALI) and reactive airway syndrome (RAS). Moreover, Cl2 exposure can occur in diverse situations encompassing mass casualty scenarios, highlighting the nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5cf1f4053078f30542c88093d5ce78
https://doi.org/10.1016/j.freeradbiomed.2012.08.007
https://doi.org/10.1016/j.freeradbiomed.2012.08.007
Autor:
Stephen F. Doran, Andreas Bracher, Giuseppe L. Squadrito, Michelle V. Fanucchi, Solana Fernandez, Sadis Matalon, Edward M. Postlethwait, Larry E. Bowen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:599-606
We assessed the safety and efficacy of combined intravenous and aerosolized antioxidant administration to attenuate chlorine gas–induced airway alterations when administered after exposure. Adult male Sprague-Dawley rats were exposed to air or 400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deac117c99032676a30c8d7719bc9400
https://doi.org/10.1165/rcmb.2011-0196oc
https://doi.org/10.1165/rcmb.2011-0196oc
Autor:
Ashwini A. Katre, Edward M. Postlethwait, Rui-Ming Liu, Michelle V. Fanucchi, Hasina Akhter, Carol A. Ballinger, Dae-Kee Kim
Publikováno v:
Inhalation Toxicology. 23:486-494
Ozone (O3), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O3-induced pulmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265d2b7fd5db326bddcd4144416b294c
https://doi.org/10.3109/08958378.2011.584919
https://doi.org/10.3109/08958378.2011.584919
Autor:
Stephan A. Carey, Edward M. Postlethwait, Michelle V. Fanucchi, Alfred A. Bartolucci, Jack R. Harkema, Ruth J. McDonald, Carol A. Ballinger, Kinjal Maniar-Hew, Lisa A. Miller, Michael J. Evans
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L462-L471
Early life is a dynamic period of growth for the lung and immune system. We hypothesized that ambient ozone exposure during postnatal development can affect the innate immune response to other environmental challenges in a persistent fashion. To test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0bfeb9061295921d0959b83633c8c2
https://doi.org/10.1152/ajplung.00254.2010
https://doi.org/10.1152/ajplung.00254.2010
Autor:
Jian-He Wu, Edward M. Postlethwait, Victor J. Thannickal, Rui-Ming Liu, Kimberly A. Gaston Pravia, J. David Lambeth, James S. Hagood, N. S. Reyes Mochel, Jeffrey D. Brand, Henry Jay Forman, Jinah Choi, Karen M. Lewis, David M. Krzywanski
Publikováno v:
Journal of Biological Chemistry. 285:16239-16247
Transforming growth factor beta (TGF-beta) stimulates reactive oxygen species (ROS) production in various cell types, which mediates many of the effects of TGF-beta. The molecular mechanisms whereby TGF-beta increases ROS production and ROS modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d795accfde6a9ca7bb80aa4e281125
https://doi.org/10.1074/jbc.m110.111732
https://doi.org/10.1074/jbc.m110.111732
Autor:
Martin Leustik, Sadis Matalon, Andreas Bracher, Giuseppe L. Squadrito, Trenton R. Schoeb, Edward M. Postlethwait, Shawn Williams, Stephen F. Doran
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 295:L733-L743
Chlorine (Cl2) is a highly reactive oxidant gas used extensively in a number of industrial processes. Exposure to high concentrations of Cl2 results in acute lung injury that may either resolve spontaneously or progress to acute respiratory failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23bad86040560d50b2c026235a00ea6
https://doi.org/10.1152/ajplung.90240.2008
https://doi.org/10.1152/ajplung.90240.2008