Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Edward M. Levine"'
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111299- (2024)
Summary: It is advantageous to culture the ex vivo retina and other tissues at the air-liquid interface to allow for more efficient gas exchange. However, gene delivery to these cultures can be challenging. Electroporation is a fast and robust method
Externí odkaz:
https://doaj.org/article/703dce7f7a784c8388073165b9f9aed2
Autor:
Jose J. Rico-Jimenez, Joel Jovanovic, Stephanie L. Nolen, Joseph D. Malone, Gopikrishna M. Rao, Edward M. Levine, Yuankai K. Tao
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
IntroductionLaser-induced photodamage is a robust method for investigating retinal pathologies in small animals. However, aiming of the photocoagulation laser is often limited by manual alignment and lacks real-time feedback on lesion location and se
Externí odkaz:
https://doaj.org/article/fca72cfa479e4dbd8b901948b2529a43
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across
Externí odkaz:
https://doaj.org/article/aa7cf044ceaa4b68b820fb9976896b7b
Autor:
Andy Shao, Antonio Jacobo Lopez, JiaJia Chen, Addy Tham, Seanne Javier, Alejandra Quiroz, Sonia Frick, Edward M. Levine, K. C. Kent Lloyd, Brian C. Leonard, Christopher J. Murphy, Thomas M. Glaser, Ala Moshiri
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 7 (2022)
Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activatin
Externí odkaz:
https://doaj.org/article/1e0ef4641f5c422b9cd28293ca0d8764
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Müller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müll
Externí odkaz:
https://doaj.org/article/2934f8e7eaba4145a803c3a158948070
Autor:
Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song, Young-In Sohn, Dae-Jin Park, Sun-Sook Paik, Joo-ri Kim-Kaneyama, Mi-Ryoung Song, Amanda Leung, Edward M Levine, In-Beom Kim, Yong Sook Goo, Seung-Hee Lee, Kyung Hwa Kang, Jin Woo Kim
Publikováno v:
eLife, Vol 6 (2017)
The visual responses of vertebrates are sensitive to the overall composition of retinal interneurons including amacrine cells, which tune the activity of the retinal circuitry. The expression of Paired-homeobox 6 (PAX6) is regulated by multiple cis-D
Externí odkaz:
https://doaj.org/article/f0f855a44e114ea1bbbebf0b3e7a55cf
Autor:
Xiaodong Li, Patrick J Gordon, John A Gaynes, Alexandra W Fuller, Randy Ringuette, Clayton P Santiago, Valerie Wallace, Seth Blackshaw, Pulin Li, Edward M Levine
Publikováno v:
eLife. 11
An important question in organogenesis is how tissue-specific transcription factors interact with signaling pathways. In some cases, transcription factors define the context for how signaling pathways elicit tissue- or cell-specific responses, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9935c8151d4a7b80e515fff126eafd95
https://pubmed.ncbi.nlm.nih.gov/36459481
https://pubmed.ncbi.nlm.nih.gov/36459481
Autor:
Edward M. Levine, Pulin Li, Seth Blackshaw, Valerie A. Wallace, Clayton P. Santiago, Randy Ringuette, Alexandra W. Fuller, John A. Gaynes, Patrick J. Gordon, Xiaodong Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f13056604675f0cab6fdd88f9dc3d91
https://doi.org/10.15252/rc.2022584400
https://doi.org/10.15252/rc.2022584400
Autor:
Andy Shao, Antonio Jacobo Lopez, JiaJia Chen, Addy Tham, Seanne Javier, Alejandra Quiroz, Sonia Frick, Edward M. Levine, K. C. Kent Lloyd, Brian C. Leonard, Christopher J. Murphy, Thomas M. Glaser, Ala Moshiri
Publikováno v:
Disease modelsmechanisms. 15(7)
Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c586f12628f1254acff9de635519878d
https://pubmed.ncbi.nlm.nih.gov/35758026
https://pubmed.ncbi.nlm.nih.gov/35758026