Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Edward M. Hedgecock"'
Autor:
Daisuke D. Ikeda, Yukan Duan, Harald Hutter, Hirofumi Kunitomo, Yuichi Iino, Masahiro Matsuki, Edward M. Hedgecock
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5260-5265
Calsyntenins/alcadeins are type I transmembrane proteins with two extracellular cadherin domains highly expressed in mammalian brain. They form a tripartite complex with X11/X11L and APP (amyloid precursor protein) and are proteolytically processed i
Publikováno v:
Molecular Genetics and Genomics. 273:158-166
Homozygosity for a mutation in the idi-1 gene of Caenorhabditis elegans results in paralysis during the first larval stage, followed by an arrest of growth and development late in the first larval stage. Apoptotic corpses, which are apparently the re
Publikováno v:
Development
The nervous system consists of diverse subtypes of neurons, whose identities must be specified during development. One important aspect of the differentiation program of neurons is the expression of the appropriate set of genes controlling axon pathw
Publikováno v:
Genes & Development. 14:1512-1527
Thedaf-12gene acts at the convergence of pathways regulating larval diapause, developmental age, and adult longevity inCaenorhabditis elegans. It encodes a nuclear receptor most closely related to twoC. elegansreceptors, NHR-8 and NHR-48,DrosophilaDH
Publikováno v:
Development. 127:1197-1207
Over 30 Caenorhabditis elegans mutants were identified with normal muscle differentiation and initial locomotion followed by catastrophic detachment of skeletal muscles from the body wall. Reducing the strength of muscle contraction in these mutants
Autor:
Xiaoping Zhu, John Spieth, Edward M. Hedgecock, Bruce E. Vogel, Chaobo Guo, John Plenefisch, Rui B. Proenca, Surjeet Mastwal, Harald Hutter, Carolyn R. Norris, Jochen Scheel
Publikováno v:
Science
New proteins and modules have been invented throughout evolution. Gene “birth dates” in Caenorhabditis elegans range from the origins of cellular life through adaptation to a soil habitat. Possibly half are “metazoan” genes, having arisen som
Publikováno v:
Developmental Biology. 214:227-241
The excretory cell extends a tubular process, or canal, along the basolateral surface of the epidermis to form the nematode renal epithelium. This cell can undergo normal tubulogenesis in isolated cell culture. Mutations in 12 genes cause excretory c
Publikováno v:
Journal of Neurobiology. 39:107-118
The nervous system of Caenorhabditis elegans comprises circumferential and longitudinal axon tracts. Netrin UNC-6 is required for the guidance of circumferential axon migrations and is expressed by ventral neuroglia and neurons in temporally and spat
Publikováno v:
DNA Sequence. 10:207-217
A new genetic locus, epi-1, has been identified and mapped, which affects epithelialization of various tissues in the nematode, Caenorhabditis elegans. Seven independent epi-1 mutant alleles have been obtained. These mutants have a wide spectrum of a
Publikováno v:
Development. 125:1191-1205
From egg through adult, C. elegans has six life stages including an option for dauer formation and diapause at larval stage L3 in adverse environments. Somatic cells throughout the organism make consistent choices and advance in unison, suggesting a