Výsledky vyhledávání - "Edward M. Curran"

Data from Loss of Estrogen Receptor Signaling Triggers Epigenetic Silencing of Downstream Targets in Breast Cancer

Autor: Tim H-M. Huang, Kenneth P. Nephew, Christoph Plass, Ramana V. Davuluri, Susan H. Wei, Wade V. Welshons, Edward M. Curran, Joseph C. Liu, Victor X. Jin, Meiyun Fan, Pearlly S. Yan, Yu-Wei Leu

Alterations in histones, chromatin-related proteins, and DNA methylation contribute to transcriptional silencing in cancer, but the sequence of these molecular events is not well understood. Here we demonstrate that on disruption of estrogen receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2526467a4737a42b08074751fd73395c
https://doi.org/10.1158/0008-5472.c.6493629.v1

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Estrogen Increases Menopausal Host Susceptibility to Experimental Ascending Urinary‐Tract Infection

Autor: Barbara M. Judy, B. Nowicki, Valerie Montgomery-Rice, D. Mark Estes, Audrey Hart-Van Tassell, Stella Nowicki, Edward M. Curran

Publikováno v: The Journal of Infectious Diseases. 195:680-683

The protective effect of estrogen replacement on ascending urinary-tract infection (UTI) is controversial. We designed a study using an experimental model of UTI in which surgically menopausal mice were supplemented with estrogen and the susceptibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0608f744c8d91cdaffb70c6eae612289
https://doi.org/10.1086/511275

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Estradiol activates mast cells via a non-genomic estrogen receptor-α and calcium influx

Autor: Edward G. Brooks, D. Mark Estes, Randall M. Goldblum, Shin Ichiro Narita, K. Chad Lambert, James J. Grady, Masafumi Zaitsu, Edward M. Curran, Cheryl S. Watson, Terumi Midoro-Horiuti

Publikováno v: Molecular Immunology. 44:1977-1985

Allergic airway diseases are more common in females than in males during early adulthood. A relationship between female hormones and asthma prevalence and severity has been suggested, but the cellular and molecular mechanisms are not understood.To el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2136bb1468a6a0b9195df629eafbf397
https://doi.org/10.1016/j.molimm.2006.09.030

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Estrogenic Regulation of Host Immunity against an Estrogen Receptor–Negative Human Breast Cancer

Autor: D. Mark Estes, Hui-Qun Wang, Ngozi A. Duru, Dennis B. Lubahn, Barbara M. Judy, Leoncio A. Vergara, Edward M. Curran

Publikováno v: Clinical Cancer Research. 12:5641-5647

Purpose: The risk of developing breast cancer is positively correlated with exposure to increased levels of estrogen and/or an increased duration of estrogen exposure. Many different mechanisms have been proposed to explain the association of estroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d2f9f1a4c5d9fa6fe46dff4bd52e07
https://doi.org/10.1158/1078-0432.ccr-05-1117

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Environmental Estrogens Induce Mast Cell Degranulation and Enhance IgE-Mediated Release of Allergic Mediators

Autor: Cheryl S. Watson, Edward M. Curran, Shin Ichiro Narita, D. Mark Estes, Randall M. Goldblum, Terumi Midoro-Horiuti, Edward G. Brooks

Publikováno v: Environmental Health Perspectives

The prevalence and morbidity of asthma and other allergic diseases have increased dramatically during the last 30 years, particularly in industrial countries (Burr et al. 2006). The onset of asthma most commonly occurs in early childhood (Yunginger e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3101ecee8e146ea2afc45e79da4a4001
http://europepmc.org/articles/PMC1797832

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Estrogen Receptor α (ERα) Deficiency in Macrophages Results in Increased Stimulation of CD4+ T Cells while 17β-Estradiol Acts through ERα to Increase IL-4 and GATA-3 Expression in CD4+ T Cells Independent of Antigen Presentation

Autor: D. Mark Estes, Gregg N. Milligan, Edward M. Curran, Dennis B. Lubahn, Barbara M. Judy, K. Chad Lambert

Publikováno v: The Journal of Immunology. 175:5716-5723

The effects of 17β-estradiol (E2) on immune function have been extensively reported. The effects are dependent on concentration and duration of exposure and potential differences in signaling between the known E2 receptors, estrogen receptors (ER) �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae1a58fb8fb27c954fab0e3b2b335da
https://doi.org/10.4049/jimmunol.175.9.5716

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Loss of Estrogen Receptor Signaling Triggers Epigenetic Silencing of Downstream Targets in Breast Cancer

Autor: Yu-Wei Leu, Wade V. Welshons, Pearlly S. Yan, Edward M. Curran, Ramana V. Davuluri, Tim H M Huang, Meiyun Fan, Joseph Liu, Christoph Plass, Susan H. Wei, Victor X. Jin, Kenneth P. Nephew

Publikováno v: Cancer Research. 64:8184-8192

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d766c482586837ddb8b3f8ddc85d514
https://doi.org/10.1158/0008-5472.can-04-2045

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Estrogen receptor-α deficiency promotes increased TNF-α secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro

Autor: Edward M. Curran, D. Mark Estes, K. Chad Lambert, Dennis B. Lubahn, Barbara M. Judy

Publikováno v: Journal of Leukocyte Biology. 75:1166-1172

In this series of studies, we determined the potential role of intracellular estrogen receptors (ER), ERalpha and ERbeta, on macrophage function in response to bacterial stimuli. The sex hormone 17beta-estradiol (E(2)) and ER have been shown to modul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ae4849fc80c85a6dcf2d0bdc0a2bea
https://doi.org/10.1189/jlb.1103589

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Transcription factor accessibility and histone acetylation of the progesterone receptor gene differs between parental MCF-7 cells and a subline that has lost progesterone receptor expression

Autor: Wade V. Welshons, Michael K. Fritsch, Xiaojie Xu, Fern E. Murdoch, Edward M. Curran

Publikováno v: Gene. 328:143-151

The human progesterone receptor ( PgR ) gene has a complex promoter that produces alternate mRNAs encoding the PgRA (94 kDa) and PgRB (120 kDa) protein isoforms. Expression of PgR is induced by estradiol (E 2 ) in the breast, reproductive tract and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73cd638aecc31c8007c4e4d4aa163cc
https://doi.org/10.1016/j.gene.2003.12.003

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