Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edward M. Courchaine"'
Autor:
Korinna Straube, Edward M. Courchaine, Martin Machyna, Jade Enright, Sarah Sauyet, Karla M. Neugebauer
Cajal bodies (CBs) are ubiquitous nuclear membraneless organelles (MLOs) that promote efficient biogenesis of RNA-protein complexes. Depletion of the CB scaffolding protein coilin is lethal for vertebrate embryogenesis, making CBs a strong model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26b6681b9a1234a19458f468f93680f
https://doi.org/10.1101/2021.08.01.454609
https://doi.org/10.1101/2021.08.01.454609
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Autor:
Harvey J. Kliman, Arun R. Chavan, Liza Konnikova, Feimei Liu, Albert I. Ko, Pavithra Vijayakumar, Seth Guller, Aaron M. Ring, Akiko Iwasaki, Katherine H. Campbell, Jessica Toothaker, Hannah J. Lee, Raffaella A. Morotti, John Fournier, Scott D. Pope, Kristin M. Milano, Eric Song, Nathan D. Grubaugh, Karla M. Neugebauer, Yale Impact Team, William J. Lu-Culligan, Santos Bermejo, Shelli F. Farhadian, Edward M. Courchaine, Zhonghua Tang, Adam J. Moore, Wade L. Schulz, M. Catherine Muenker, Arnau Casanovas-Massana, Lina Irshaid, Alice Lu-Culligan, Chantal B.F. Vogels
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Pregnant women appear to be at increased risk for severe outcomes associated with COVID-19, but the pathophysiology underlying this increased morbidity and its potential impact on the developing fetus is not well understood. In this study of pregnant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e095d5f483330c0f46e295df28404e
https://doi.org/10.1101/2021.01.25.21250452
https://doi.org/10.1101/2021.01.25.21250452
Autor:
Joerg Bewersdorf, Karla M. Neugebauer, Korinna Straube, Andrew E.S. Barentine, Edward M. Courchaine
SummaryBiomolecular condensation is a widespread mechanism of cellular compartmentalization. Because the ‘survival of motor neuron protein’ (SMN) is required for the formation of three different membraneless organelles (MLOs), we hypothesized tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1ab3c2334513daa9c056899fbfe471
https://doi.org/10.1101/2020.09.15.297994
https://doi.org/10.1101/2020.09.15.297994
Autor:
Andrew E.S. Barentine, Dong-Ryoung Lee, Korinna Straube, Edward M. Courchaine, Karla M. Neugebauer, Joerg Bewersdorf
Publikováno v:
Cell
Summary Biomolecular condensation is a widespread mechanism of cellular compartmentalization. Because the "survival of motor neuron protein" (SMN) is implicated in the formation of three different membraneless organelles (MLOs), we hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3396460ecd4fe43816aedc662509fd03
https://doi.org/10.1016/j.cell.2021.05.008
https://doi.org/10.1016/j.cell.2021.05.008
Autor:
Scott D. Pope, Kristin M. Milano, Liza Konnikova, Lina Irshaid, Wade L. Schulz, William J. Lu-Culligan, Aaron M. Ring, Akiko Iwasaki, Arnau Casanovas-Massana, Shelli F. Farhadian, Arun R. Chavan, Harvey J. Kliman, M. Catherine Muenker, Chantal B.F. Vogels, Feimei Liu, Nathan D. Grubaugh, Santos Bermejo, Jessica Toothaker, Pavithra Vijayakumar, Adam J. Moore, Albert I. Ko, Edward M. Courchaine, Seth Guller, Eric Song, Raffaella A. Morotti, Katherine H. Campbell, Zhonghua Tang, Hannah J. Lee, John Fournier, Karla M. Neugebauer, Alice Lu-Culligan
Publikováno v:
Med (New York, N.y.)
Background Pregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and its potential effect on the developing fetus is not well understood. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2671e97d26f127db3592f72de4e7138
https://doi.org/10.1016/j.medj.2021.04.016
https://doi.org/10.1016/j.medj.2021.04.016
Autor:
David Baddeley, Miao Liu, Edward M. Courchaine, Joerg Bewersdorf, Juliana Rios Chen, Zach Marin, Yu Lin, Siyuan Wang, Michael R. Grace, Andrew E.S. Barentine, Leonhard Balduf, Phylicia Kidd
Publikováno v:
Biophysical Journal. 120:181a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c674b9a27bbc6f7ef8ab69887b2805
https://doi.org/10.1016/j.bpj.2020.11.1261
https://doi.org/10.1016/j.bpj.2020.11.1261
Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by lipid bilayers. These compartments are implicated in a wide range of cellular activities, and they have been variously described as bodies, granules, or organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4ea9365dc3fa388736219558d94d7a
https://europepmc.org/articles/PMC4969579/
https://europepmc.org/articles/PMC4969579/
Publikováno v:
Biophysical Journal. 114:440a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e543b3bf6e0b69184e4989610853bd0e
https://doi.org/10.1016/j.bpj.2017.11.2434
https://doi.org/10.1016/j.bpj.2017.11.2434
Publikováno v:
The Journal of Cell Biology
Paraspeckles are mammalian subnuclear bodies built on a long noncoding RNA and are enriched in RNA binding proteins with prion-like domains; two of these proteins, RBM14 and FUS, use these domains to hold paraspeckles together.
Prion-like domain
Prion-like domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd7532615310d022a1c5629d1be6045
https://pubmed.ncbi.nlm.nih.gov/26283796
https://pubmed.ncbi.nlm.nih.gov/26283796