Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Edward M Campbell"'
Autor:
Sevnur Kömürlü, Margret Bradley, Nikolai Smolin, Sabrina Imam, Raymond F Pauszek, Seth L Robia, David Millar, Emi E Nakayama, Tatsuo Shioda, Edward M Campbell
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of hu
Externí odkaz:
https://doaj.org/article/cb7efc497121450da84a870033e43ddf
Autor:
Sarah Talley, Tyler Nguyen, Lily Van Ye, Rasa Valiauga, Jake DeCarlo, Jabra Mustafa, Benjamin Cook, Fletcher A. White, Edward M. Campbell
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome. However, most studies t
Externí odkaz:
https://doaj.org/article/03c269e231da4bc2862c77acd286425d
Autor:
Marcin D Roganowicz, Sevnur Komurlu, Santanu Mukherjee, Jacek Plewka, Steven L Alam, Katarzyna A Skorupka, Yueping Wan, Damian Dawidowski, David S Cafiso, Barbie K Ganser-Pornillos, Edward M Campbell, Owen Pornillos
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006686 (2017)
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-spe
Externí odkaz:
https://doaj.org/article/df135015d24340ad92100211730e0580
Autor:
Adarsh Dharan, Sarah Talley, Abhishek Tripathi, João I Mamede, Matthias Majetschak, Thomas J Hope, Edward M Campbell
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005700 (2016)
Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the target cell and undergoes a series of trafficking and replicative steps that result in the nuclear import of the viral genome, which ultimately leads to the inte
Externí odkaz:
https://doaj.org/article/3c4afb2c571d4540870ef21c9133dfe1
Autor:
Phong T Le, Meghan M Pearce, Shubin Zhang, Edward M Campbell, Cynthia S Fok, Elizabeth R Mueller, Cynthia A Brincat, Alan J Wolfe, Linda Brubaker
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111375 (2014)
Human urinary disorders are generally studied in rodent models due to limitations of functional in vitro culture models of primary human urothelial cells (HUCs). Current HUC culture models are often derived from immortalized cancer cell lines, which
Externí odkaz:
https://doaj.org/article/e445cfd8f89b4b68a2fbfb0410fcea90
Autor:
David Freeman, Rudy Cedillos, Samantha Choyke, Zana Lukic, Kathleen McGuire, Shauna Marvin, Andrew M Burrage, Stacey Sudholt, Ajay Rana, Christopher O'Connor, Christopher M Wiethoff, Edward M Campbell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62143 (2013)
α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular m
Externí odkaz:
https://doaj.org/article/41aa07bb8d2b404984b03817f68565d6
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-14 (2023)
Abstract A severe complication of hematopoietic stem cell transplantation is graft-versus-host disease (GvHD), a reaction that occurs following the transfer of donor immune cells (the graft) into an allogeneic host. Transplanted cells recognize host
Externí odkaz:
https://doaj.org/article/85ad02c587d04006b7d73817c1d1aef6
Autor:
Tyler Nguyen, Natalie Nguyen, Ashlyn G. Cochran, Jared A. Smith, Mohammed Al-Juboori, Andrew Brumett, Saahil Saxena, Sarah Talley, Edward M. Campbell, Alexander G. Obukhov, Fletcher A. White
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of mTBI-associated chronic pain, t
Externí odkaz:
https://doaj.org/article/82e6c3eeda304ff39cf7e974ecaf5bdf
Autor:
Tyler Nguyen, Sarah Talley, Natalie Nguyen, Ashlyn G. Cochran, Mohammed Al-Juboori, Jared A. Smith, Saahil Saxena, Edward M. Campbell, Alexander G. Obukhov, Fletcher A. White
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 135-136 (2023)
OBJECTIVES/GOALS: Patients who have experienced conjunctive mild traumatic brain injuries (mTBIs) suffer from a number of comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of mTBI-associated chro
Externí odkaz:
https://doaj.org/article/1bf6dc11398a482cbb0a252b52275ca9
Publikováno v:
AIDS Res Hum Retroviruses
AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome